Favipiravir Inhibits Mayaro Virus Infection in Mice

Mayaro virus (MAYV) is an emergent alphavirus that causes MAYV fever. It is often associated with debilitating symptoms, particularly arthralgia and myalgia. MAYV infection is becoming a considerable health issue that, unfortunately, lacks a specific antiviral treatment. Favipiravir, a broad-spectru...

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Autores principales:	Michèle Bengue, Ai-rada Pintong, Florian Liegeois, Antoine Nougairède, Rodolphe Hamel, Julien Pompon, Xavier de Lamballerie, Pierre Roques, Valérie Choumet, Dorothée Missé
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	alphavirus arbovirus mayaro favipiravir antiviral drug Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/59e6bc8854224139ad3ecc58127e8a23
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spelling	oai:doaj.org-article:59e6bc8854224139ad3ecc58127e8a232021-11-25T19:13:23ZFavipiravir Inhibits Mayaro Virus Infection in Mice10.3390/v131122131999-4915https://doaj.org/article/59e6bc8854224139ad3ecc58127e8a232021-11-01T00:00:00Zhttps://www.mdpi.com/1999-4915/13/11/2213https://doaj.org/toc/1999-4915Mayaro virus (MAYV) is an emergent alphavirus that causes MAYV fever. It is often associated with debilitating symptoms, particularly arthralgia and myalgia. MAYV infection is becoming a considerable health issue that, unfortunately, lacks a specific antiviral treatment. Favipiravir, a broad-spectrum antiviral drug, has recently been shown to exert anti-MAYV activity in vitro. In the present study, the potential of Favipiravir to inhibit MAYV replication in an in vivo model was evaluated. Immunocompetent mice were orally administrated 300 mg/kg/dose of Favipiravir at pre-, concurrent-, or post-MAYV infection. The results showed a significant reduction in infectious viral particles and viral RNA transcripts in the tissues and blood of the pre- and concurrently treated infected mice. A significant reduction in the presence of both viral RNA transcript and infectious viral particles in the tissue and blood of pre- and concurrently treated infected mice was observed. By contrast, Favipiravir treatment post-MAYV infection did not result in a reduction in viral replication. Interestingly, Favipiravir strongly decreased the blood levels of the liver disease markers aspartate- and alanine aminotransferase in the pre- and concurrently treated MAYV-infected mice. Taken together, these results suggest that Favipiravir is a potent antiviral drug when administered in a timely manner.Michèle BengueAi-rada PintongFlorian LiegeoisAntoine NougairèdeRodolphe HamelJulien PomponXavier de LamballeriePierre RoquesValérie ChoumetDorothée MisséMDPI AGarticlealphavirusarbovirusmayarofavipiravirantiviral drugMicrobiologyQR1-502ENViruses, Vol 13, Iss 2213, p 2213 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	alphavirus arbovirus mayaro favipiravir antiviral drug Microbiology QR1-502
spellingShingle	alphavirus arbovirus mayaro favipiravir antiviral drug Microbiology QR1-502 Michèle Bengue Ai-rada Pintong Florian Liegeois Antoine Nougairède Rodolphe Hamel Julien Pompon Xavier de Lamballerie Pierre Roques Valérie Choumet Dorothée Missé Favipiravir Inhibits Mayaro Virus Infection in Mice
description	Mayaro virus (MAYV) is an emergent alphavirus that causes MAYV fever. It is often associated with debilitating symptoms, particularly arthralgia and myalgia. MAYV infection is becoming a considerable health issue that, unfortunately, lacks a specific antiviral treatment. Favipiravir, a broad-spectrum antiviral drug, has recently been shown to exert anti-MAYV activity in vitro. In the present study, the potential of Favipiravir to inhibit MAYV replication in an in vivo model was evaluated. Immunocompetent mice were orally administrated 300 mg/kg/dose of Favipiravir at pre-, concurrent-, or post-MAYV infection. The results showed a significant reduction in infectious viral particles and viral RNA transcripts in the tissues and blood of the pre- and concurrently treated infected mice. A significant reduction in the presence of both viral RNA transcript and infectious viral particles in the tissue and blood of pre- and concurrently treated infected mice was observed. By contrast, Favipiravir treatment post-MAYV infection did not result in a reduction in viral replication. Interestingly, Favipiravir strongly decreased the blood levels of the liver disease markers aspartate- and alanine aminotransferase in the pre- and concurrently treated MAYV-infected mice. Taken together, these results suggest that Favipiravir is a potent antiviral drug when administered in a timely manner.
format	article
author	Michèle Bengue Ai-rada Pintong Florian Liegeois Antoine Nougairède Rodolphe Hamel Julien Pompon Xavier de Lamballerie Pierre Roques Valérie Choumet Dorothée Missé
author_facet	Michèle Bengue Ai-rada Pintong Florian Liegeois Antoine Nougairède Rodolphe Hamel Julien Pompon Xavier de Lamballerie Pierre Roques Valérie Choumet Dorothée Missé
author_sort	Michèle Bengue
title	Favipiravir Inhibits Mayaro Virus Infection in Mice
title_short	Favipiravir Inhibits Mayaro Virus Infection in Mice
title_full	Favipiravir Inhibits Mayaro Virus Infection in Mice
title_fullStr	Favipiravir Inhibits Mayaro Virus Infection in Mice
title_full_unstemmed	Favipiravir Inhibits Mayaro Virus Infection in Mice
title_sort	favipiravir inhibits mayaro virus infection in mice
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/59e6bc8854224139ad3ecc58127e8a23
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Favipiravir Inhibits Mayaro Virus Infection in Mice

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