NS5A Domain 1 and Polyprotein Cleavage Kinetics Are Critical for Induction of Double-Membrane Vesicles Associated with Hepatitis C Virus Replication

NS5A Domain 1 and Polyprotein Cleavage Kinetics Are Critical for Induction of Double-Membrane Vesicles Associated with Hepatitis C Virus Replication

ABSTRACT Induction of membrane rearrangements in the cytoplasm of infected cells is a hallmark of positive-strand RNA viruses. These altered membranes serve as scaffolds for the assembly of viral replication factories (RFs). We have recently shown that hepatitis C virus (HCV) infection induces endop...

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Autores principales: Inés Romero-Brey, Carola Berger, Stephanie Kallis, Androniki Kolovou, David Paul, Volker Lohmann, Ralf Bartenschlager
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2015
Materias:
Microbiology
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Acceso en línea:https://doaj.org/article/59eeeb27fb1d4084a333e576613d3490
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