Lure-and-kill macrophage nanoparticles alleviate the severity of experimental acute pancreatitis

Phospholipase A2 (PLA2) inhibitors have been shown to be able to treat acute pancreatitis, but are toxic with systemic application. Here the authors design a nanoparticle with macrophage membrane components to carry PLA2 inhibitor to macrophages and treat pancreatitis in mice, with no evidence of to...

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Autores principales:	Qiangzhe Zhang, Julia Zhou, Jiarong Zhou, Ronnie H. Fang, Weiwei Gao, Liangfang Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/59f18735054a47048206ef29c77b2fa5
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spelling	oai:doaj.org-article:59f18735054a47048206ef29c77b2fa52021-12-02T18:34:21ZLure-and-kill macrophage nanoparticles alleviate the severity of experimental acute pancreatitis10.1038/s41467-021-24447-42041-1723https://doaj.org/article/59f18735054a47048206ef29c77b2fa52021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24447-4https://doaj.org/toc/2041-1723Phospholipase A2 (PLA2) inhibitors have been shown to be able to treat acute pancreatitis, but are toxic with systemic application. Here the authors design a nanoparticle with macrophage membrane components to carry PLA2 inhibitor to macrophages and treat pancreatitis in mice, with no evidence of toxicity.Qiangzhe ZhangJulia ZhouJiarong ZhouRonnie H. FangWeiwei GaoLiangfang ZhangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qiangzhe Zhang Julia Zhou Jiarong Zhou Ronnie H. Fang Weiwei Gao Liangfang Zhang Lure-and-kill macrophage nanoparticles alleviate the severity of experimental acute pancreatitis
description	Phospholipase A2 (PLA2) inhibitors have been shown to be able to treat acute pancreatitis, but are toxic with systemic application. Here the authors design a nanoparticle with macrophage membrane components to carry PLA2 inhibitor to macrophages and treat pancreatitis in mice, with no evidence of toxicity.
format	article
author	Qiangzhe Zhang Julia Zhou Jiarong Zhou Ronnie H. Fang Weiwei Gao Liangfang Zhang
author_facet	Qiangzhe Zhang Julia Zhou Jiarong Zhou Ronnie H. Fang Weiwei Gao Liangfang Zhang
author_sort	Qiangzhe Zhang
title	Lure-and-kill macrophage nanoparticles alleviate the severity of experimental acute pancreatitis
title_short	Lure-and-kill macrophage nanoparticles alleviate the severity of experimental acute pancreatitis
title_full	Lure-and-kill macrophage nanoparticles alleviate the severity of experimental acute pancreatitis
title_fullStr	Lure-and-kill macrophage nanoparticles alleviate the severity of experimental acute pancreatitis
title_full_unstemmed	Lure-and-kill macrophage nanoparticles alleviate the severity of experimental acute pancreatitis
title_sort	lure-and-kill macrophage nanoparticles alleviate the severity of experimental acute pancreatitis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/59f18735054a47048206ef29c77b2fa5
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Lure-and-kill macrophage nanoparticles alleviate the severity of experimental acute pancreatitis

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