Lure-and-kill macrophage nanoparticles alleviate the severity of experimental acute pancreatitis

Phospholipase A2 (PLA2) inhibitors have been shown to be able to treat acute pancreatitis, but are toxic with systemic application. Here the authors design a nanoparticle with macrophage membrane components to carry PLA2 inhibitor to macrophages and treat pancreatitis in mice, with no evidence of to...

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Autores principales: Qiangzhe Zhang, Julia Zhou, Jiarong Zhou, Ronnie H. Fang, Weiwei Gao, Liangfang Zhang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/59f18735054a47048206ef29c77b2fa5
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