Machine learning uncovers independently regulated modules in the Bacillus subtilis transcriptome

The systems-level regulatory structure underlying gene expression in bacteria can be inferred using machine learning algorithms. Here we show this structure for Bacillus subtilis, present five hypotheses gleaned from it, and analyse the process of sporulation from its perspective.

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Detalles Bibliográficos
Autores principales:	Kevin Rychel, Anand V. Sastry, Bernhard O. Palsson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/59f3566d3cf849209f58e55fa61b9d55
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spelling	oai:doaj.org-article:59f3566d3cf849209f58e55fa61b9d552021-12-02T10:48:11ZMachine learning uncovers independently regulated modules in the Bacillus subtilis transcriptome10.1038/s41467-020-20153-92041-1723https://doaj.org/article/59f3566d3cf849209f58e55fa61b9d552020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20153-9https://doaj.org/toc/2041-1723The systems-level regulatory structure underlying gene expression in bacteria can be inferred using machine learning algorithms. Here we show this structure for Bacillus subtilis, present five hypotheses gleaned from it, and analyse the process of sporulation from its perspective.Kevin RychelAnand V. SastryBernhard O. PalssonNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kevin Rychel Anand V. Sastry Bernhard O. Palsson Machine learning uncovers independently regulated modules in the Bacillus subtilis transcriptome
description	The systems-level regulatory structure underlying gene expression in bacteria can be inferred using machine learning algorithms. Here we show this structure for Bacillus subtilis, present five hypotheses gleaned from it, and analyse the process of sporulation from its perspective.
format	article
author	Kevin Rychel Anand V. Sastry Bernhard O. Palsson
author_facet	Kevin Rychel Anand V. Sastry Bernhard O. Palsson
author_sort	Kevin Rychel
title	Machine learning uncovers independently regulated modules in the Bacillus subtilis transcriptome
title_short	Machine learning uncovers independently regulated modules in the Bacillus subtilis transcriptome
title_full	Machine learning uncovers independently regulated modules in the Bacillus subtilis transcriptome
title_fullStr	Machine learning uncovers independently regulated modules in the Bacillus subtilis transcriptome
title_full_unstemmed	Machine learning uncovers independently regulated modules in the Bacillus subtilis transcriptome
title_sort	machine learning uncovers independently regulated modules in the bacillus subtilis transcriptome
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/59f3566d3cf849209f58e55fa61b9d55
work_keys_str_mv	AT kevinrychel machinelearninguncoversindependentlyregulatedmodulesinthebacillussubtilistranscriptome AT anandvsastry machinelearninguncoversindependentlyregulatedmodulesinthebacillussubtilistranscriptome AT bernhardopalsson machinelearninguncoversindependentlyregulatedmodulesinthebacillussubtilistranscriptome
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Machine learning uncovers independently regulated modules in the Bacillus subtilis transcriptome

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