Tortuous Pore Path Through the Glaucomatous Lamina Cribrosa

Abstract The lamina cribrosa is a primary site of damage in glaucoma. While mechanical distortion is hypothesized to cause reduction of axoplasmic flow, little is known about how the pores, which contains the retinal ganglion cell axons, traverse the lamina cribrosa. We investigated lamina cribrosa...

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Autores principales:	Bo Wang, Katie A. Lucy, Joel S. Schuman, Ian A. Sigal, Richard A. Bilonick, Chen Lu, Jonathan Liu, Ireneusz Grulkowski, Zachary Nadler, Hiroshi Ishikawa, Larry Kagemann, James G. Fujimoto, Gadi Wollstein
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/59f39a05013d4683b1993c1562a34630
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spelling	oai:doaj.org-article:59f39a05013d4683b1993c1562a346302021-12-02T11:41:25ZTortuous Pore Path Through the Glaucomatous Lamina Cribrosa10.1038/s41598-018-25645-92045-2322https://doaj.org/article/59f39a05013d4683b1993c1562a346302018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-25645-9https://doaj.org/toc/2045-2322Abstract The lamina cribrosa is a primary site of damage in glaucoma. While mechanical distortion is hypothesized to cause reduction of axoplasmic flow, little is known about how the pores, which contains the retinal ganglion cell axons, traverse the lamina cribrosa. We investigated lamina cribrosa pore paths in vivo to quantify differences in tortuosity of pore paths between healthy and glaucomatous eyes. We imaged 16 healthy, 23 glaucoma suspect and 48 glaucomatous eyes from 70 subjects using a swept source optical coherence tomography system. The lamina cribrosa pores were automatically segmented using a previously described segmentation algorithm. Individual pore paths were automatically tracked through the depth of the lamina cribrosa using custom software. Pore path convergence to the optic nerve center and tortuosity was quantified for each eye. We found that lamina cribrosa pore pathways traverse the lamina cribrosa closer to the optic nerve center along the depth of the lamina cribrosa regardless of disease severity or diagnostic category. In addition, pores of glaucoma eyes take a more tortuous path through the lamina cribrosa compared to those of healthy eyes, suggesting a potential mechanism for reduction of axoplasmic flow in glaucoma.Bo WangKatie A. LucyJoel S. SchumanIan A. SigalRichard A. BilonickChen LuJonathan LiuIreneusz GrulkowskiZachary NadlerHiroshi IshikawaLarry KagemannJames G. FujimotoGadi WollsteinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-7 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Bo Wang Katie A. Lucy Joel S. Schuman Ian A. Sigal Richard A. Bilonick Chen Lu Jonathan Liu Ireneusz Grulkowski Zachary Nadler Hiroshi Ishikawa Larry Kagemann James G. Fujimoto Gadi Wollstein Tortuous Pore Path Through the Glaucomatous Lamina Cribrosa
description	Abstract The lamina cribrosa is a primary site of damage in glaucoma. While mechanical distortion is hypothesized to cause reduction of axoplasmic flow, little is known about how the pores, which contains the retinal ganglion cell axons, traverse the lamina cribrosa. We investigated lamina cribrosa pore paths in vivo to quantify differences in tortuosity of pore paths between healthy and glaucomatous eyes. We imaged 16 healthy, 23 glaucoma suspect and 48 glaucomatous eyes from 70 subjects using a swept source optical coherence tomography system. The lamina cribrosa pores were automatically segmented using a previously described segmentation algorithm. Individual pore paths were automatically tracked through the depth of the lamina cribrosa using custom software. Pore path convergence to the optic nerve center and tortuosity was quantified for each eye. We found that lamina cribrosa pore pathways traverse the lamina cribrosa closer to the optic nerve center along the depth of the lamina cribrosa regardless of disease severity or diagnostic category. In addition, pores of glaucoma eyes take a more tortuous path through the lamina cribrosa compared to those of healthy eyes, suggesting a potential mechanism for reduction of axoplasmic flow in glaucoma.
format	article
author	Bo Wang Katie A. Lucy Joel S. Schuman Ian A. Sigal Richard A. Bilonick Chen Lu Jonathan Liu Ireneusz Grulkowski Zachary Nadler Hiroshi Ishikawa Larry Kagemann James G. Fujimoto Gadi Wollstein
author_facet	Bo Wang Katie A. Lucy Joel S. Schuman Ian A. Sigal Richard A. Bilonick Chen Lu Jonathan Liu Ireneusz Grulkowski Zachary Nadler Hiroshi Ishikawa Larry Kagemann James G. Fujimoto Gadi Wollstein
author_sort	Bo Wang
title	Tortuous Pore Path Through the Glaucomatous Lamina Cribrosa
title_short	Tortuous Pore Path Through the Glaucomatous Lamina Cribrosa
title_full	Tortuous Pore Path Through the Glaucomatous Lamina Cribrosa
title_fullStr	Tortuous Pore Path Through the Glaucomatous Lamina Cribrosa
title_full_unstemmed	Tortuous Pore Path Through the Glaucomatous Lamina Cribrosa
title_sort	tortuous pore path through the glaucomatous lamina cribrosa
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/59f39a05013d4683b1993c1562a34630
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Tortuous Pore Path Through the Glaucomatous Lamina Cribrosa

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