GABA concentration in posterior cingulate cortex predicts putamen response during resting state fMRI.

The role of neurotransmitters in the activity of resting state networks has been gaining attention and has become a field of research with magnetic resonance spectroscopy (MRS) being one of the key techniques. MRS permits the measurement of γ-aminobutyric acid (GABA) and glutamate levels, the centra...

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Autores principales:	Jorge Arrubla, Desmond H Y Tse, Christin Amkreutz, Irene Neuner, N Jon Shah
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/59f3ad9db3f741468afd0187f98dd6ed
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spelling	oai:doaj.org-article:59f3ad9db3f741468afd0187f98dd6ed2021-11-25T06:02:01ZGABA concentration in posterior cingulate cortex predicts putamen response during resting state fMRI.1932-620310.1371/journal.pone.0106609https://doaj.org/article/59f3ad9db3f741468afd0187f98dd6ed2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25184505/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203The role of neurotransmitters in the activity of resting state networks has been gaining attention and has become a field of research with magnetic resonance spectroscopy (MRS) being one of the key techniques. MRS permits the measurement of γ-aminobutyric acid (GABA) and glutamate levels, the central biochemical constituents of the excitation-inhibition balance in vivo. The inhibitory effects of GABA in the brain have been largely investigated in relation to the activity of resting state networks in functional magnetic resonance imaging (fMRI). In this study GABA concentration in the posterior cingulate cortex (PCC) was measured using single voxel spectra acquired with standard point resolved spectroscopy (PRESS) from 20 healthy male volunteers at 3 T. Resting state fMRI was consecutively measured and the values of GABA/Creatine+Phosphocreatine ratio (GABA ratio) were included in a general linear model matrix as a step of dual regression analysis in order to identify voxels whose neuroimaging metrics during rest were related to individual levels of the GABA ratio. Our data show that the connection strength of putamen to the default-mode network during resting state has a negative linear relationship with the GABA ratio measured in the PCC. These findings highlight the role of PCC and GABA in segregation of the motor input, which is an inherent condition that characterises resting state.Jorge ArrublaDesmond H Y TseChristin AmkreutzIrene NeunerN Jon ShahPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 9, p e106609 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jorge Arrubla Desmond H Y Tse Christin Amkreutz Irene Neuner N Jon Shah GABA concentration in posterior cingulate cortex predicts putamen response during resting state fMRI.
description	The role of neurotransmitters in the activity of resting state networks has been gaining attention and has become a field of research with magnetic resonance spectroscopy (MRS) being one of the key techniques. MRS permits the measurement of γ-aminobutyric acid (GABA) and glutamate levels, the central biochemical constituents of the excitation-inhibition balance in vivo. The inhibitory effects of GABA in the brain have been largely investigated in relation to the activity of resting state networks in functional magnetic resonance imaging (fMRI). In this study GABA concentration in the posterior cingulate cortex (PCC) was measured using single voxel spectra acquired with standard point resolved spectroscopy (PRESS) from 20 healthy male volunteers at 3 T. Resting state fMRI was consecutively measured and the values of GABA/Creatine+Phosphocreatine ratio (GABA ratio) were included in a general linear model matrix as a step of dual regression analysis in order to identify voxels whose neuroimaging metrics during rest were related to individual levels of the GABA ratio. Our data show that the connection strength of putamen to the default-mode network during resting state has a negative linear relationship with the GABA ratio measured in the PCC. These findings highlight the role of PCC and GABA in segregation of the motor input, which is an inherent condition that characterises resting state.
format	article
author	Jorge Arrubla Desmond H Y Tse Christin Amkreutz Irene Neuner N Jon Shah
author_facet	Jorge Arrubla Desmond H Y Tse Christin Amkreutz Irene Neuner N Jon Shah
author_sort	Jorge Arrubla
title	GABA concentration in posterior cingulate cortex predicts putamen response during resting state fMRI.
title_short	GABA concentration in posterior cingulate cortex predicts putamen response during resting state fMRI.
title_full	GABA concentration in posterior cingulate cortex predicts putamen response during resting state fMRI.
title_fullStr	GABA concentration in posterior cingulate cortex predicts putamen response during resting state fMRI.
title_full_unstemmed	GABA concentration in posterior cingulate cortex predicts putamen response during resting state fMRI.
title_sort	gaba concentration in posterior cingulate cortex predicts putamen response during resting state fmri.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/59f3ad9db3f741468afd0187f98dd6ed
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GABA concentration in posterior cingulate cortex predicts putamen response during resting state fMRI.

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