Morpho-functional changes of cardiac telocytes in isolated atrial amyloidosis in patients with atrial fibrillation

Abstract Telocytes are interstitial cells with long, thin processes by which they contact each other and form a network in the interstitium. Myocardial remodeling of adult patients with different forms of atrial fibrillation (AF) occurs with an increase in fibrosis, age-related isolated atrial amylo...

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Autores principales:	Tatyana V. Sukhacheva, Natalia V. Nizyaeva, Maria V. Samsonova, Andrey L. Cherniaev, Artem A. Burov, Mariia V. Iurova, Aleksandr I. Shchegolev, Roman A. Serov, Gennady T. Sukhikh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/59f3fe6ae45048bd946b2a989243d7b8
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spelling	oai:doaj.org-article:59f3fe6ae45048bd946b2a989243d7b82021-12-02T13:30:09ZMorpho-functional changes of cardiac telocytes in isolated atrial amyloidosis in patients with atrial fibrillation10.1038/s41598-021-82554-02045-2322https://doaj.org/article/59f3fe6ae45048bd946b2a989243d7b82021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82554-0https://doaj.org/toc/2045-2322Abstract Telocytes are interstitial cells with long, thin processes by which they contact each other and form a network in the interstitium. Myocardial remodeling of adult patients with different forms of atrial fibrillation (AF) occurs with an increase in fibrosis, age-related isolated atrial amyloidosis (IAA), cardiomyocyte hypertrophy and myolysis. This study aimed to determine the ultrastructural and immunohistochemical features of cardiac telocytes in patients with AF and AF + IAA. IAA associated with accumulation of atrial natriuretic factor was detected in 4.3–25% biopsies of left (LAA) and 21.7–41.7% of right (RAA) atrial appendage myocardium. Telocytes were identified at ultrastructural level more often in AF + IAA, than in AF group and correlated with AF duration and mitral valve regurgitation. Telocytes had ultrastructural signs of synthetic, proliferative, and phagocytic activity. Telocytes corresponded to CD117+, vimentin+, CD34+, CD44+, CD68+, CD16+, S100-, CD105- immunophenotype. No significant differences in telocytes morphology and immunophenotype were found in patients with various forms of AF. CD68-positive cells were detected more often in AF + IAA than AF group. We assume that in aged AF + IAA patients remodeling of atrial myocardium provoked transformation of telocytes into “transitional forms” combining the morphological and immunohistochemical features with signs of fibroblast-, histiocyte- and endotheliocyte-like cells.Tatyana V. SukhachevaNatalia V. NizyaevaMaria V. SamsonovaAndrey L. CherniaevArtem A. BurovMariia V. IurovaAleksandr I. ShchegolevRoman A. SerovGennady T. SukhikhNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tatyana V. Sukhacheva Natalia V. Nizyaeva Maria V. Samsonova Andrey L. Cherniaev Artem A. Burov Mariia V. Iurova Aleksandr I. Shchegolev Roman A. Serov Gennady T. Sukhikh Morpho-functional changes of cardiac telocytes in isolated atrial amyloidosis in patients with atrial fibrillation
description	Abstract Telocytes are interstitial cells with long, thin processes by which they contact each other and form a network in the interstitium. Myocardial remodeling of adult patients with different forms of atrial fibrillation (AF) occurs with an increase in fibrosis, age-related isolated atrial amyloidosis (IAA), cardiomyocyte hypertrophy and myolysis. This study aimed to determine the ultrastructural and immunohistochemical features of cardiac telocytes in patients with AF and AF + IAA. IAA associated with accumulation of atrial natriuretic factor was detected in 4.3–25% biopsies of left (LAA) and 21.7–41.7% of right (RAA) atrial appendage myocardium. Telocytes were identified at ultrastructural level more often in AF + IAA, than in AF group and correlated with AF duration and mitral valve regurgitation. Telocytes had ultrastructural signs of synthetic, proliferative, and phagocytic activity. Telocytes corresponded to CD117+, vimentin+, CD34+, CD44+, CD68+, CD16+, S100-, CD105- immunophenotype. No significant differences in telocytes morphology and immunophenotype were found in patients with various forms of AF. CD68-positive cells were detected more often in AF + IAA than AF group. We assume that in aged AF + IAA patients remodeling of atrial myocardium provoked transformation of telocytes into “transitional forms” combining the morphological and immunohistochemical features with signs of fibroblast-, histiocyte- and endotheliocyte-like cells.
format	article
author	Tatyana V. Sukhacheva Natalia V. Nizyaeva Maria V. Samsonova Andrey L. Cherniaev Artem A. Burov Mariia V. Iurova Aleksandr I. Shchegolev Roman A. Serov Gennady T. Sukhikh
author_facet	Tatyana V. Sukhacheva Natalia V. Nizyaeva Maria V. Samsonova Andrey L. Cherniaev Artem A. Burov Mariia V. Iurova Aleksandr I. Shchegolev Roman A. Serov Gennady T. Sukhikh
author_sort	Tatyana V. Sukhacheva
title	Morpho-functional changes of cardiac telocytes in isolated atrial amyloidosis in patients with atrial fibrillation
title_short	Morpho-functional changes of cardiac telocytes in isolated atrial amyloidosis in patients with atrial fibrillation
title_full	Morpho-functional changes of cardiac telocytes in isolated atrial amyloidosis in patients with atrial fibrillation
title_fullStr	Morpho-functional changes of cardiac telocytes in isolated atrial amyloidosis in patients with atrial fibrillation
title_full_unstemmed	Morpho-functional changes of cardiac telocytes in isolated atrial amyloidosis in patients with atrial fibrillation
title_sort	morpho-functional changes of cardiac telocytes in isolated atrial amyloidosis in patients with atrial fibrillation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/59f3fe6ae45048bd946b2a989243d7b8
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Morpho-functional changes of cardiac telocytes in isolated atrial amyloidosis in patients with atrial fibrillation

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