Structural basis for the inhibition of HTLV-1 integration inferred from cryo-EM deltaretroviral intasome structures

Human T-cell lymphotropic virus type 1 (HTLV-1) is an oncogenic deltaretrovirus. Here the authors provide structural characterization of the binding mechanism of novel integrase strand transfer inhibitor (INSTI) candidates to limit HTLV-1 infection.

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Autores principales:	Michal S. Barski, Teresa Vanzo, Xue Zhi Zhao, Steven J. Smith, Allison Ballandras-Colas, Nora B. Cronin, Valerie E. Pye, Stephen H. Hughes, Terrence R. Burke, Peter Cherepanov, Goedele N. Maertens
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/59f4a48f98624dc5b1b3112f666af4df
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spelling	oai:doaj.org-article:59f4a48f98624dc5b1b3112f666af4df2021-12-02T15:10:35ZStructural basis for the inhibition of HTLV-1 integration inferred from cryo-EM deltaretroviral intasome structures10.1038/s41467-021-25284-12041-1723https://doaj.org/article/59f4a48f98624dc5b1b3112f666af4df2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25284-1https://doaj.org/toc/2041-1723Human T-cell lymphotropic virus type 1 (HTLV-1) is an oncogenic deltaretrovirus. Here the authors provide structural characterization of the binding mechanism of novel integrase strand transfer inhibitor (INSTI) candidates to limit HTLV-1 infection.Michal S. BarskiTeresa VanzoXue Zhi ZhaoSteven J. SmithAllison Ballandras-ColasNora B. CroninValerie E. PyeStephen H. HughesTerrence R. BurkePeter CherepanovGoedele N. MaertensNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Michal S. Barski Teresa Vanzo Xue Zhi Zhao Steven J. Smith Allison Ballandras-Colas Nora B. Cronin Valerie E. Pye Stephen H. Hughes Terrence R. Burke Peter Cherepanov Goedele N. Maertens Structural basis for the inhibition of HTLV-1 integration inferred from cryo-EM deltaretroviral intasome structures
description	Human T-cell lymphotropic virus type 1 (HTLV-1) is an oncogenic deltaretrovirus. Here the authors provide structural characterization of the binding mechanism of novel integrase strand transfer inhibitor (INSTI) candidates to limit HTLV-1 infection.
format	article
author	Michal S. Barski Teresa Vanzo Xue Zhi Zhao Steven J. Smith Allison Ballandras-Colas Nora B. Cronin Valerie E. Pye Stephen H. Hughes Terrence R. Burke Peter Cherepanov Goedele N. Maertens
author_facet	Michal S. Barski Teresa Vanzo Xue Zhi Zhao Steven J. Smith Allison Ballandras-Colas Nora B. Cronin Valerie E. Pye Stephen H. Hughes Terrence R. Burke Peter Cherepanov Goedele N. Maertens
author_sort	Michal S. Barski
title	Structural basis for the inhibition of HTLV-1 integration inferred from cryo-EM deltaretroviral intasome structures
title_short	Structural basis for the inhibition of HTLV-1 integration inferred from cryo-EM deltaretroviral intasome structures
title_full	Structural basis for the inhibition of HTLV-1 integration inferred from cryo-EM deltaretroviral intasome structures
title_fullStr	Structural basis for the inhibition of HTLV-1 integration inferred from cryo-EM deltaretroviral intasome structures
title_full_unstemmed	Structural basis for the inhibition of HTLV-1 integration inferred from cryo-EM deltaretroviral intasome structures
title_sort	structural basis for the inhibition of htlv-1 integration inferred from cryo-em deltaretroviral intasome structures
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/59f4a48f98624dc5b1b3112f666af4df
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Structural basis for the inhibition of HTLV-1 integration inferred from cryo-EM deltaretroviral intasome structures

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