FUT2–ABO epistasis increases the risk of early childhood asthma and Streptococcus pneumoniae respiratory illnesses

Genetic variants discovered through genome-wide association studies for asthma together account for a small portion of the heritability. Here, the authors identify a possible epistatic relationship between coding variants in FUT2 and ABO, especially pronounced in severe and early onset asthma.

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Autores principales:	Tarunveer S. Ahluwalia, Anders U. Eliasen, Astrid Sevelsted, Casper-Emil T. Pedersen, Jakob Stokholm, Bo Chawes, Jette Bork-Jensen, Niels Grarup, Oluf Pedersen, Torben Hansen, Allan Linneberg, Amitabh Sharma, Scott T. Weiss, Michael D. Evans, Daniel J. Jackson, Andreanne Morin, Karen A. Krogfelt, Susanne Schjørring, Preben B. Mortensen, David M. Hougaard, Jonas Bybjerg-Grauholm, Marie Bækvad-Hansen, Ole Mors, Merete Nordentoft, Anders D. Børglum, Thomas Werge, Esben Agerbo, James E. Gern, Robert F. Lemanske, Carole Ober, Anders G. Pedersen, Hans Bisgaard, Klaus Bønnelykke
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/59f595f1821040ab9ab6a0e9a00cad59
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spelling	oai:doaj.org-article:59f595f1821040ab9ab6a0e9a00cad592021-12-02T13:27:30ZFUT2–ABO epistasis increases the risk of early childhood asthma and Streptococcus pneumoniae respiratory illnesses10.1038/s41467-020-19814-62041-1723https://doaj.org/article/59f595f1821040ab9ab6a0e9a00cad592020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19814-6https://doaj.org/toc/2041-1723Genetic variants discovered through genome-wide association studies for asthma together account for a small portion of the heritability. Here, the authors identify a possible epistatic relationship between coding variants in FUT2 and ABO, especially pronounced in severe and early onset asthma.Tarunveer S. AhluwaliaAnders U. EliasenAstrid SevelstedCasper-Emil T. PedersenJakob StokholmBo ChawesJette Bork-JensenNiels GrarupOluf PedersenTorben HansenAllan LinnebergAmitabh SharmaScott T. WeissMichael D. EvansDaniel J. JacksonAndreanne MorinKaren A. KrogfeltSusanne SchjørringPreben B. MortensenDavid M. HougaardJonas Bybjerg-GrauholmMarie Bækvad-HansenOle MorsMerete NordentoftAnders D. BørglumThomas WergeEsben AgerboJames E. GernRobert F. LemanskeCarole OberAnders G. PedersenHans BisgaardKlaus BønnelykkeNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tarunveer S. Ahluwalia Anders U. Eliasen Astrid Sevelsted Casper-Emil T. Pedersen Jakob Stokholm Bo Chawes Jette Bork-Jensen Niels Grarup Oluf Pedersen Torben Hansen Allan Linneberg Amitabh Sharma Scott T. Weiss Michael D. Evans Daniel J. Jackson Andreanne Morin Karen A. Krogfelt Susanne Schjørring Preben B. Mortensen David M. Hougaard Jonas Bybjerg-Grauholm Marie Bækvad-Hansen Ole Mors Merete Nordentoft Anders D. Børglum Thomas Werge Esben Agerbo James E. Gern Robert F. Lemanske Carole Ober Anders G. Pedersen Hans Bisgaard Klaus Bønnelykke FUT2–ABO epistasis increases the risk of early childhood asthma and Streptococcus pneumoniae respiratory illnesses
description	Genetic variants discovered through genome-wide association studies for asthma together account for a small portion of the heritability. Here, the authors identify a possible epistatic relationship between coding variants in FUT2 and ABO, especially pronounced in severe and early onset asthma.
format	article
author	Tarunveer S. Ahluwalia Anders U. Eliasen Astrid Sevelsted Casper-Emil T. Pedersen Jakob Stokholm Bo Chawes Jette Bork-Jensen Niels Grarup Oluf Pedersen Torben Hansen Allan Linneberg Amitabh Sharma Scott T. Weiss Michael D. Evans Daniel J. Jackson Andreanne Morin Karen A. Krogfelt Susanne Schjørring Preben B. Mortensen David M. Hougaard Jonas Bybjerg-Grauholm Marie Bækvad-Hansen Ole Mors Merete Nordentoft Anders D. Børglum Thomas Werge Esben Agerbo James E. Gern Robert F. Lemanske Carole Ober Anders G. Pedersen Hans Bisgaard Klaus Bønnelykke
author_facet	Tarunveer S. Ahluwalia Anders U. Eliasen Astrid Sevelsted Casper-Emil T. Pedersen Jakob Stokholm Bo Chawes Jette Bork-Jensen Niels Grarup Oluf Pedersen Torben Hansen Allan Linneberg Amitabh Sharma Scott T. Weiss Michael D. Evans Daniel J. Jackson Andreanne Morin Karen A. Krogfelt Susanne Schjørring Preben B. Mortensen David M. Hougaard Jonas Bybjerg-Grauholm Marie Bækvad-Hansen Ole Mors Merete Nordentoft Anders D. Børglum Thomas Werge Esben Agerbo James E. Gern Robert F. Lemanske Carole Ober Anders G. Pedersen Hans Bisgaard Klaus Bønnelykke
author_sort	Tarunveer S. Ahluwalia
title	FUT2–ABO epistasis increases the risk of early childhood asthma and Streptococcus pneumoniae respiratory illnesses
title_short	FUT2–ABO epistasis increases the risk of early childhood asthma and Streptococcus pneumoniae respiratory illnesses
title_full	FUT2–ABO epistasis increases the risk of early childhood asthma and Streptococcus pneumoniae respiratory illnesses
title_fullStr	FUT2–ABO epistasis increases the risk of early childhood asthma and Streptococcus pneumoniae respiratory illnesses
title_full_unstemmed	FUT2–ABO epistasis increases the risk of early childhood asthma and Streptococcus pneumoniae respiratory illnesses
title_sort	fut2–abo epistasis increases the risk of early childhood asthma and streptococcus pneumoniae respiratory illnesses
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/59f595f1821040ab9ab6a0e9a00cad59
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FUT2–ABO epistasis increases the risk of early childhood asthma and Streptococcus pneumoniae respiratory illnesses

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