Ethnic-specific association of amylase gene copy number with adiposity traits in a large Middle Eastern biobank

Abstract Studies assessing the impact of amylase genes copy number (CN) on adiposity report conflicting findings in different global populations, likely reflecting the impact of ancestral and ethnic-specific environment and lifestyle on selection at the amylase loci. Here, we leverage population siz...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Niccolo’ Rossi, Elbay Aliyev, Alessia Visconti, Ammira S. A. Akil, Najeeb Syed, Waleed Aamer, Sujitha S. Padmajeya, Mario Falchi, Khalid A. Fakhro
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Genetics QH426-470
Acceso en línea:	https://doaj.org/article/59facd30a1f148d1b38e59f1fc8a17dc
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:59facd30a1f148d1b38e59f1fc8a17dc
record_format	dspace
spelling	oai:doaj.org-article:59facd30a1f148d1b38e59f1fc8a17dc2021-12-02T13:30:11ZEthnic-specific association of amylase gene copy number with adiposity traits in a large Middle Eastern biobank10.1038/s41525-021-00170-32056-7944https://doaj.org/article/59facd30a1f148d1b38e59f1fc8a17dc2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41525-021-00170-3https://doaj.org/toc/2056-7944Abstract Studies assessing the impact of amylase genes copy number (CN) on adiposity report conflicting findings in different global populations, likely reflecting the impact of ancestral and ethnic-specific environment and lifestyle on selection at the amylase loci. Here, we leverage population size and detailed adiposity measures from a large population biobank to resolve confounding effects and determine the relationship between salivary (AMY1) and pancreatic (AMY2A) amylase genes CN and adiposity in 2935 Qatari individuals who underwent whole-genome sequencing (WGS) as part of the Qatar Genome Programme. We observe a negative association between AMY1 CNs and trunk fat percentage in the Qatari population (P = 7.50 × 10−3) and show that Qataris of Arab descent have significantly lower CN at AMY1 (P = 1.32 × 10−10) as well as less favorable adiposity and metabolic profiles (P < 1.34 × 10−8) than Qataris with Persian ancestry. Indeed, lower AMY1 CN was associated with increased total and trunk fat percentages in Arabs (P < 4.60 × 10−3) but not in Persians. Notably, overweight and obese Persians reported a significant trend towards dietary restraint following weight gain compared to Arabs (P = 4.29 × 10−5), with AMY1 CN showing negative association with dietary self-restraint (P = 3.22 × 10−3). This study reports an association between amylase gene CN and adiposity traits in a large Middle Eastern population. Importantly, we leverage rich biobank data to demonstrate that the strength of this association varies with ethnicity, and may be influenced by population-specific behaviors that also contribute to adiposity traits.Niccolo’ RossiElbay AliyevAlessia ViscontiAmmira S. A. AkilNajeeb SyedWaleed AamerSujitha S. PadmajeyaMario FalchiKhalid A. FakhroNature PortfolioarticleMedicineRGeneticsQH426-470ENnpj Genomic Medicine, Vol 6, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Genetics QH426-470
spellingShingle	Medicine R Genetics QH426-470 Niccolo’ Rossi Elbay Aliyev Alessia Visconti Ammira S. A. Akil Najeeb Syed Waleed Aamer Sujitha S. Padmajeya Mario Falchi Khalid A. Fakhro Ethnic-specific association of amylase gene copy number with adiposity traits in a large Middle Eastern biobank
description	Abstract Studies assessing the impact of amylase genes copy number (CN) on adiposity report conflicting findings in different global populations, likely reflecting the impact of ancestral and ethnic-specific environment and lifestyle on selection at the amylase loci. Here, we leverage population size and detailed adiposity measures from a large population biobank to resolve confounding effects and determine the relationship between salivary (AMY1) and pancreatic (AMY2A) amylase genes CN and adiposity in 2935 Qatari individuals who underwent whole-genome sequencing (WGS) as part of the Qatar Genome Programme. We observe a negative association between AMY1 CNs and trunk fat percentage in the Qatari population (P = 7.50 × 10−3) and show that Qataris of Arab descent have significantly lower CN at AMY1 (P = 1.32 × 10−10) as well as less favorable adiposity and metabolic profiles (P < 1.34 × 10−8) than Qataris with Persian ancestry. Indeed, lower AMY1 CN was associated with increased total and trunk fat percentages in Arabs (P < 4.60 × 10−3) but not in Persians. Notably, overweight and obese Persians reported a significant trend towards dietary restraint following weight gain compared to Arabs (P = 4.29 × 10−5), with AMY1 CN showing negative association with dietary self-restraint (P = 3.22 × 10−3). This study reports an association between amylase gene CN and adiposity traits in a large Middle Eastern population. Importantly, we leverage rich biobank data to demonstrate that the strength of this association varies with ethnicity, and may be influenced by population-specific behaviors that also contribute to adiposity traits.
format	article
author	Niccolo’ Rossi Elbay Aliyev Alessia Visconti Ammira S. A. Akil Najeeb Syed Waleed Aamer Sujitha S. Padmajeya Mario Falchi Khalid A. Fakhro
author_facet	Niccolo’ Rossi Elbay Aliyev Alessia Visconti Ammira S. A. Akil Najeeb Syed Waleed Aamer Sujitha S. Padmajeya Mario Falchi Khalid A. Fakhro
author_sort	Niccolo’ Rossi
title	Ethnic-specific association of amylase gene copy number with adiposity traits in a large Middle Eastern biobank
title_short	Ethnic-specific association of amylase gene copy number with adiposity traits in a large Middle Eastern biobank
title_full	Ethnic-specific association of amylase gene copy number with adiposity traits in a large Middle Eastern biobank
title_fullStr	Ethnic-specific association of amylase gene copy number with adiposity traits in a large Middle Eastern biobank
title_full_unstemmed	Ethnic-specific association of amylase gene copy number with adiposity traits in a large Middle Eastern biobank
title_sort	ethnic-specific association of amylase gene copy number with adiposity traits in a large middle eastern biobank
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/59facd30a1f148d1b38e59f1fc8a17dc
work_keys_str_mv	AT niccolorossi ethnicspecificassociationofamylasegenecopynumberwithadipositytraitsinalargemiddleeasternbiobank AT elbayaliyev ethnicspecificassociationofamylasegenecopynumberwithadipositytraitsinalargemiddleeasternbiobank AT alessiavisconti ethnicspecificassociationofamylasegenecopynumberwithadipositytraitsinalargemiddleeasternbiobank AT ammirasaakil ethnicspecificassociationofamylasegenecopynumberwithadipositytraitsinalargemiddleeasternbiobank AT najeebsyed ethnicspecificassociationofamylasegenecopynumberwithadipositytraitsinalargemiddleeasternbiobank AT waleedaamer ethnicspecificassociationofamylasegenecopynumberwithadipositytraitsinalargemiddleeasternbiobank AT sujithaspadmajeya ethnicspecificassociationofamylasegenecopynumberwithadipositytraitsinalargemiddleeasternbiobank AT mariofalchi ethnicspecificassociationofamylasegenecopynumberwithadipositytraitsinalargemiddleeasternbiobank AT khalidafakhro ethnicspecificassociationofamylasegenecopynumberwithadipositytraitsinalargemiddleeasternbiobank
_version_	1718392975403253760

Ethnic-specific association of amylase gene copy number with adiposity traits in a large Middle Eastern biobank

Ejemplares similares