Molecular pathways involved in COVID-19 and potential pathway-based therapeutic targets

Deciphering the molecular downstream consequences of severe acute respiratory syndrome coronavirus (SARS-CoV)− 2 infection is important for a greater understanding of the disease and treatment planning. Furthermore, greater understanding of the underlying mechanisms of diagnostic and therapeutic str...

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Autores principales:	Masoumeh Farahani, Zahra Niknam, Leila Mohammadi Amirabad, Nasrin Amiri-Dashatan, Mehdi Koushki, Mohadeseh Nemati, Fahima Danesh Pouya, Mostafa Rezaei-Tavirani, Yousef Rasmi, Lobat Tayebi
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	COVID-19 SARS-CoV-2 Molecular pathway Drug targets Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/59fba64d54b344619feaa8a70e8fdf81
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spelling	oai:doaj.org-article:59fba64d54b344619feaa8a70e8fdf812021-11-20T04:55:51ZMolecular pathways involved in COVID-19 and potential pathway-based therapeutic targets0753-332210.1016/j.biopha.2021.112420https://doaj.org/article/59fba64d54b344619feaa8a70e8fdf812022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0753332221012063https://doaj.org/toc/0753-3322Deciphering the molecular downstream consequences of severe acute respiratory syndrome coronavirus (SARS-CoV)− 2 infection is important for a greater understanding of the disease and treatment planning. Furthermore, greater understanding of the underlying mechanisms of diagnostic and therapeutic strategies can help in the development of vaccines and drugs against COVID-19. At present, the molecular mechanisms of SARS-CoV-2 in the host cells are not sufficiently comprehended. Some of the mechanisms are proposed considering the existing similarities between SARS-CoV-2 and the other members of the β-CoVs, and others are explained based on studies advanced in the structure and function of SARS-CoV-2. In this review, we endeavored to map the possible mechanisms of the host response following SARS-CoV-2 infection and surveyed current research conducted by in vitro, in vivo and human observations, as well as existing suggestions. We addressed the specific signaling events that can cause cytokine storm and demonstrated three forms of cell death signaling following virus infection, including apoptosis, pyroptosis, and necroptosis. Given the elicited signaling pathways, we introduced possible pathway-based therapeutic targets; ADAM17 was especially highlighted as one of the most important elements of several signaling pathways involved in the immunopathogenesis of COVID-19. We also provided the possible drug candidates against these targets. Moreover, the cytokine-cytokine receptor interaction pathway was found as one of the important cross-talk pathways through a pathway-pathway interaction analysis for SARS-CoV-2 infection.Masoumeh FarahaniZahra NiknamLeila Mohammadi AmirabadNasrin Amiri-DashatanMehdi KoushkiMohadeseh NematiFahima Danesh PouyaMostafa Rezaei-TaviraniYousef RasmiLobat TayebiElsevierarticleCOVID-19SARS-CoV-2Molecular pathwayDrug targetsTherapeutics. PharmacologyRM1-950ENBiomedicine & Pharmacotherapy, Vol 145, Iss , Pp 112420- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	COVID-19 SARS-CoV-2 Molecular pathway Drug targets Therapeutics. Pharmacology RM1-950
spellingShingle	COVID-19 SARS-CoV-2 Molecular pathway Drug targets Therapeutics. Pharmacology RM1-950 Masoumeh Farahani Zahra Niknam Leila Mohammadi Amirabad Nasrin Amiri-Dashatan Mehdi Koushki Mohadeseh Nemati Fahima Danesh Pouya Mostafa Rezaei-Tavirani Yousef Rasmi Lobat Tayebi Molecular pathways involved in COVID-19 and potential pathway-based therapeutic targets
description	Deciphering the molecular downstream consequences of severe acute respiratory syndrome coronavirus (SARS-CoV)− 2 infection is important for a greater understanding of the disease and treatment planning. Furthermore, greater understanding of the underlying mechanisms of diagnostic and therapeutic strategies can help in the development of vaccines and drugs against COVID-19. At present, the molecular mechanisms of SARS-CoV-2 in the host cells are not sufficiently comprehended. Some of the mechanisms are proposed considering the existing similarities between SARS-CoV-2 and the other members of the β-CoVs, and others are explained based on studies advanced in the structure and function of SARS-CoV-2. In this review, we endeavored to map the possible mechanisms of the host response following SARS-CoV-2 infection and surveyed current research conducted by in vitro, in vivo and human observations, as well as existing suggestions. We addressed the specific signaling events that can cause cytokine storm and demonstrated three forms of cell death signaling following virus infection, including apoptosis, pyroptosis, and necroptosis. Given the elicited signaling pathways, we introduced possible pathway-based therapeutic targets; ADAM17 was especially highlighted as one of the most important elements of several signaling pathways involved in the immunopathogenesis of COVID-19. We also provided the possible drug candidates against these targets. Moreover, the cytokine-cytokine receptor interaction pathway was found as one of the important cross-talk pathways through a pathway-pathway interaction analysis for SARS-CoV-2 infection.
format	article
author	Masoumeh Farahani Zahra Niknam Leila Mohammadi Amirabad Nasrin Amiri-Dashatan Mehdi Koushki Mohadeseh Nemati Fahima Danesh Pouya Mostafa Rezaei-Tavirani Yousef Rasmi Lobat Tayebi
author_facet	Masoumeh Farahani Zahra Niknam Leila Mohammadi Amirabad Nasrin Amiri-Dashatan Mehdi Koushki Mohadeseh Nemati Fahima Danesh Pouya Mostafa Rezaei-Tavirani Yousef Rasmi Lobat Tayebi
author_sort	Masoumeh Farahani
title	Molecular pathways involved in COVID-19 and potential pathway-based therapeutic targets
title_short	Molecular pathways involved in COVID-19 and potential pathway-based therapeutic targets
title_full	Molecular pathways involved in COVID-19 and potential pathway-based therapeutic targets
title_fullStr	Molecular pathways involved in COVID-19 and potential pathway-based therapeutic targets
title_full_unstemmed	Molecular pathways involved in COVID-19 and potential pathway-based therapeutic targets
title_sort	molecular pathways involved in covid-19 and potential pathway-based therapeutic targets
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/59fba64d54b344619feaa8a70e8fdf81
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Molecular pathways involved in COVID-19 and potential pathway-based therapeutic targets

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