Co-evolution based machine-learning for predicting functional interactions between human genes

With the rise in number of eukaryotic species being fully sequenced, large scale phylogenetic profiling can give insights on gene function, Here, the authors describe a machine-learning approach that integrates co-evolution across eukaryotic clades to predict gene function and functional interaction...

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Autores principales: Doron Stupp, Elad Sharon, Idit Bloch, Marinka Zitnik, Or Zuk, Yuval Tabach
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/59ff6a7933cf40ff80afbe2c5b1265df
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Sumario:With the rise in number of eukaryotic species being fully sequenced, large scale phylogenetic profiling can give insights on gene function, Here, the authors describe a machine-learning approach that integrates co-evolution across eukaryotic clades to predict gene function and functional interactions among human genes.