Balancing feed-forward excitation and inhibition via Hebbian inhibitory synaptic plasticity.

It has been suggested that excitatory and inhibitory inputs to cortical cells are balanced, and that this balance is important for the highly irregular firing observed in the cortex. There are two hypotheses as to the origin of this balance. One assumes that it results from a stable solution of the...

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Autores principales:	Yotam Luz, Maoz Shamir
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/5a0467b0221a45bb83e0455a32224c9f
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spelling	oai:doaj.org-article:5a0467b0221a45bb83e0455a32224c9f2021-11-18T05:51:37ZBalancing feed-forward excitation and inhibition via Hebbian inhibitory synaptic plasticity.1553-734X1553-735810.1371/journal.pcbi.1002334https://doaj.org/article/5a0467b0221a45bb83e0455a32224c9f2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22291583/?tool=EBIhttps://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358It has been suggested that excitatory and inhibitory inputs to cortical cells are balanced, and that this balance is important for the highly irregular firing observed in the cortex. There are two hypotheses as to the origin of this balance. One assumes that it results from a stable solution of the recurrent neuronal dynamics. This model can account for a balance of steady state excitation and inhibition without fine tuning of parameters, but not for transient inputs. The second hypothesis suggests that the feed forward excitatory and inhibitory inputs to a postsynaptic cell are already balanced. This latter hypothesis thus does account for the balance of transient inputs. However, it remains unclear what mechanism underlies the fine tuning required for balancing feed forward excitatory and inhibitory inputs. Here we investigated whether inhibitory synaptic plasticity is responsible for the balance of transient feed forward excitation and inhibition. We address this issue in the framework of a model characterizing the stochastic dynamics of temporally anti-symmetric Hebbian spike timing dependent plasticity of feed forward excitatory and inhibitory synaptic inputs to a single post-synaptic cell. Our analysis shows that inhibitory Hebbian plasticity generates 'negative feedback' that balances excitation and inhibition, which contrasts with the 'positive feedback' of excitatory Hebbian synaptic plasticity. As a result, this balance may increase the sensitivity of the learning dynamics to the correlation structure of the excitatory inputs.Yotam LuzMaoz ShamirPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 8, Iss 1, p e1002334 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Yotam Luz Maoz Shamir Balancing feed-forward excitation and inhibition via Hebbian inhibitory synaptic plasticity.
description	It has been suggested that excitatory and inhibitory inputs to cortical cells are balanced, and that this balance is important for the highly irregular firing observed in the cortex. There are two hypotheses as to the origin of this balance. One assumes that it results from a stable solution of the recurrent neuronal dynamics. This model can account for a balance of steady state excitation and inhibition without fine tuning of parameters, but not for transient inputs. The second hypothesis suggests that the feed forward excitatory and inhibitory inputs to a postsynaptic cell are already balanced. This latter hypothesis thus does account for the balance of transient inputs. However, it remains unclear what mechanism underlies the fine tuning required for balancing feed forward excitatory and inhibitory inputs. Here we investigated whether inhibitory synaptic plasticity is responsible for the balance of transient feed forward excitation and inhibition. We address this issue in the framework of a model characterizing the stochastic dynamics of temporally anti-symmetric Hebbian spike timing dependent plasticity of feed forward excitatory and inhibitory synaptic inputs to a single post-synaptic cell. Our analysis shows that inhibitory Hebbian plasticity generates 'negative feedback' that balances excitation and inhibition, which contrasts with the 'positive feedback' of excitatory Hebbian synaptic plasticity. As a result, this balance may increase the sensitivity of the learning dynamics to the correlation structure of the excitatory inputs.
format	article
author	Yotam Luz Maoz Shamir
author_facet	Yotam Luz Maoz Shamir
author_sort	Yotam Luz
title	Balancing feed-forward excitation and inhibition via Hebbian inhibitory synaptic plasticity.
title_short	Balancing feed-forward excitation and inhibition via Hebbian inhibitory synaptic plasticity.
title_full	Balancing feed-forward excitation and inhibition via Hebbian inhibitory synaptic plasticity.
title_fullStr	Balancing feed-forward excitation and inhibition via Hebbian inhibitory synaptic plasticity.
title_full_unstemmed	Balancing feed-forward excitation and inhibition via Hebbian inhibitory synaptic plasticity.
title_sort	balancing feed-forward excitation and inhibition via hebbian inhibitory synaptic plasticity.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/5a0467b0221a45bb83e0455a32224c9f
work_keys_str_mv	AT yotamluz balancingfeedforwardexcitationandinhibitionviahebbianinhibitorysynapticplasticity AT maozshamir balancingfeedforwardexcitationandinhibitionviahebbianinhibitorysynapticplasticity
_version_	1718424726227910656

Balancing feed-forward excitation and inhibition via Hebbian inhibitory synaptic plasticity.

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