Relationship between affective symptoms and malnutrition severity in severe Anorexia Nervosa.

<h4>Background</h4>Very few studies have investigated the relationship between malnutrition and psychological symptoms in Anorexia Nervosa (AN). They have used only body weight or body mass index (BMI) for the nutritional assessment and did not always report on medication, or if they did...

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Autores principales:	Lama Mattar, Caroline Huas, EVHAN group, Nathalie Godart
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5a04e8e9f1a54d69b9681151921caf02
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spelling	oai:doaj.org-article:5a04e8e9f1a54d69b9681151921caf022021-11-18T08:08:00ZRelationship between affective symptoms and malnutrition severity in severe Anorexia Nervosa.1932-620310.1371/journal.pone.0049380https://doaj.org/article/5a04e8e9f1a54d69b9681151921caf022012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23185320/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Very few studies have investigated the relationship between malnutrition and psychological symptoms in Anorexia Nervosa (AN). They have used only body weight or body mass index (BMI) for the nutritional assessment and did not always report on medication, or if they did, it was not included in the analysis of results, and they did not include confounding factors such as duration of illness, AN subtype or age. The present study investigates this relationship using indicators other than BMI/weight, among which body composition and biological markers, also considering potential confounders related to depression and anxiety.<h4>Methods</h4>155 AN patients, (DSM-IV) were included consecutively upon admission to inpatient treatment. Depression, anxiety, obsessive behaviours and social functioning were measured using various scales. Nutritional status was measured using BMI, severity of weight loss, body composition, and albumin and prealbumin levels.<h4>Results</h4>No correlation was found between BMI at inclusion, fat-free mass index, fat mass index, and severity of weight loss and any of the psychometric scores. Age and medication are the only factors that affect the psychological scores. None of the psychological scores were explained by the nutritional indicators with the exception of albumin levels which was negatively linked to the LSAS fear score (p = 0.024; beta = -0.225). Only the use of antidepressants explained the variability in BDI scores (p = 0.029; beta = 0.228) and anxiolytic use explained the variability in HADs depression scores (p = 0.037; beta = 0.216).<h4>Conclusion</h4>The present study is a pioneer investigation of various nutritional markers in relation to psychological symptoms in severely malnourished AN patients. The clinical hypothesis that malnutrition partly causes depression and anxiety symptoms in AN in acute phase is not confirmed, and future studies are needed to back up our results.Lama MattarCaroline HuasEVHAN groupNathalie GodartPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 11, p e49380 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lama Mattar Caroline Huas EVHAN group Nathalie Godart Relationship between affective symptoms and malnutrition severity in severe Anorexia Nervosa.
description	<h4>Background</h4>Very few studies have investigated the relationship between malnutrition and psychological symptoms in Anorexia Nervosa (AN). They have used only body weight or body mass index (BMI) for the nutritional assessment and did not always report on medication, or if they did, it was not included in the analysis of results, and they did not include confounding factors such as duration of illness, AN subtype or age. The present study investigates this relationship using indicators other than BMI/weight, among which body composition and biological markers, also considering potential confounders related to depression and anxiety.<h4>Methods</h4>155 AN patients, (DSM-IV) were included consecutively upon admission to inpatient treatment. Depression, anxiety, obsessive behaviours and social functioning were measured using various scales. Nutritional status was measured using BMI, severity of weight loss, body composition, and albumin and prealbumin levels.<h4>Results</h4>No correlation was found between BMI at inclusion, fat-free mass index, fat mass index, and severity of weight loss and any of the psychometric scores. Age and medication are the only factors that affect the psychological scores. None of the psychological scores were explained by the nutritional indicators with the exception of albumin levels which was negatively linked to the LSAS fear score (p = 0.024; beta = -0.225). Only the use of antidepressants explained the variability in BDI scores (p = 0.029; beta = 0.228) and anxiolytic use explained the variability in HADs depression scores (p = 0.037; beta = 0.216).<h4>Conclusion</h4>The present study is a pioneer investigation of various nutritional markers in relation to psychological symptoms in severely malnourished AN patients. The clinical hypothesis that malnutrition partly causes depression and anxiety symptoms in AN in acute phase is not confirmed, and future studies are needed to back up our results.
format	article
author	Lama Mattar Caroline Huas EVHAN group Nathalie Godart
author_facet	Lama Mattar Caroline Huas EVHAN group Nathalie Godart
author_sort	Lama Mattar
title	Relationship between affective symptoms and malnutrition severity in severe Anorexia Nervosa.
title_short	Relationship between affective symptoms and malnutrition severity in severe Anorexia Nervosa.
title_full	Relationship between affective symptoms and malnutrition severity in severe Anorexia Nervosa.
title_fullStr	Relationship between affective symptoms and malnutrition severity in severe Anorexia Nervosa.
title_full_unstemmed	Relationship between affective symptoms and malnutrition severity in severe Anorexia Nervosa.
title_sort	relationship between affective symptoms and malnutrition severity in severe anorexia nervosa.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/5a04e8e9f1a54d69b9681151921caf02
work_keys_str_mv	AT lamamattar relationshipbetweenaffectivesymptomsandmalnutritionseverityinsevereanorexianervosa AT carolinehuas relationshipbetweenaffectivesymptomsandmalnutritionseverityinsevereanorexianervosa AT evhangroup relationshipbetweenaffectivesymptomsandmalnutritionseverityinsevereanorexianervosa AT nathaliegodart relationshipbetweenaffectivesymptomsandmalnutritionseverityinsevereanorexianervosa
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Relationship between affective symptoms and malnutrition severity in severe Anorexia Nervosa.

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