Q-elastography in the presurgical diagnosis of thyroid nodules with indeterminate cytology.

Quantitative ultrasound (US) elastography (Q-USE), able to evaluate tissue stiffness has been indicated as a new diagnostic tool to differentiate benign from malignant thyroid lesions. Aim of this prospective study, conducted at the Department of Surgical Sciences, of the "Sapienza" Univer...

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Autores principales:	Vito Cantisani, Salvatore Ulisse, Eleonora Guaitoli, Corrado De Vito, Riccardo Caruso, Renzo Mocini, Vito D'Andrea, Valeria Ascoli, Alfredo Antonaci, Carlo Catalano, Francesco Nardi, Adriano Redler, Paolo Ricci, Enrico De Antoni, Salvatore Sorrenti
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5a0698fbe97144d68f87179b23b5e960
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spelling	oai:doaj.org-article:5a0698fbe97144d68f87179b23b5e9602021-11-18T08:07:01ZQ-elastography in the presurgical diagnosis of thyroid nodules with indeterminate cytology.1932-620310.1371/journal.pone.0050725https://doaj.org/article/5a0698fbe97144d68f87179b23b5e9602012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23209819/?tool=EBIhttps://doaj.org/toc/1932-6203Quantitative ultrasound (US) elastography (Q-USE), able to evaluate tissue stiffness has been indicated as a new diagnostic tool to differentiate benign from malignant thyroid lesions. Aim of this prospective study, conducted at the Department of Surgical Sciences, of the "Sapienza" University of Rome, was to evaluate the diagnostic accuracy of Q-USE, compared with US parameters, in thyroid nodules with indeterminate cytology (Thy3).The case study included 140 nodules from 140 consecutive patients. Patient's thyroid nodules were evaluated by Q-USE, measuring the strain ratio (SR) of stiffness between nodular and surrounding normal thyroid tissue, and conventional US parameters prior fine-needle aspiration cytology. Those with Thy3 diagnosis were included in the study. Forty of the nodules analyzed harbored a malignant lesion. Q-USE demonstrated that malignant nodules have a significant higher stiffness with respect to benign one and an optimun SR cut-off value of 2.05 was individuated following ROC analysis. Univariate analysis showed that hypoechogenicity, irregular margins and SR >2.05 associated with malignancy, with an accuracy of 67.2%, 81,0% and 89.8%, respectively. Data were unaffected by nodule size or thyroiditis. These findings were confirmed in multivariate analysis demonstrating a significant association of the SR and the irregular margins with thyroid nodule's malignancy. In conclusion, we demonstrated the diagnostic utility of Q-USE in the differential diagnosis of thyroid nodules with indeterminate cytology that, if confirmed, could be of major clinical utility in patients' presurgical selection.Vito CantisaniSalvatore UlisseEleonora GuaitoliCorrado De VitoRiccardo CarusoRenzo MociniVito D'AndreaValeria AscoliAlfredo AntonaciCarlo CatalanoFrancesco NardiAdriano RedlerPaolo RicciEnrico De AntoniSalvatore SorrentiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 11, p e50725 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Vito Cantisani Salvatore Ulisse Eleonora Guaitoli Corrado De Vito Riccardo Caruso Renzo Mocini Vito D'Andrea Valeria Ascoli Alfredo Antonaci Carlo Catalano Francesco Nardi Adriano Redler Paolo Ricci Enrico De Antoni Salvatore Sorrenti Q-elastography in the presurgical diagnosis of thyroid nodules with indeterminate cytology.
description	Quantitative ultrasound (US) elastography (Q-USE), able to evaluate tissue stiffness has been indicated as a new diagnostic tool to differentiate benign from malignant thyroid lesions. Aim of this prospective study, conducted at the Department of Surgical Sciences, of the "Sapienza" University of Rome, was to evaluate the diagnostic accuracy of Q-USE, compared with US parameters, in thyroid nodules with indeterminate cytology (Thy3).The case study included 140 nodules from 140 consecutive patients. Patient's thyroid nodules were evaluated by Q-USE, measuring the strain ratio (SR) of stiffness between nodular and surrounding normal thyroid tissue, and conventional US parameters prior fine-needle aspiration cytology. Those with Thy3 diagnosis were included in the study. Forty of the nodules analyzed harbored a malignant lesion. Q-USE demonstrated that malignant nodules have a significant higher stiffness with respect to benign one and an optimun SR cut-off value of 2.05 was individuated following ROC analysis. Univariate analysis showed that hypoechogenicity, irregular margins and SR >2.05 associated with malignancy, with an accuracy of 67.2%, 81,0% and 89.8%, respectively. Data were unaffected by nodule size or thyroiditis. These findings were confirmed in multivariate analysis demonstrating a significant association of the SR and the irregular margins with thyroid nodule's malignancy. In conclusion, we demonstrated the diagnostic utility of Q-USE in the differential diagnosis of thyroid nodules with indeterminate cytology that, if confirmed, could be of major clinical utility in patients' presurgical selection.
format	article
author	Vito Cantisani Salvatore Ulisse Eleonora Guaitoli Corrado De Vito Riccardo Caruso Renzo Mocini Vito D'Andrea Valeria Ascoli Alfredo Antonaci Carlo Catalano Francesco Nardi Adriano Redler Paolo Ricci Enrico De Antoni Salvatore Sorrenti
author_facet	Vito Cantisani Salvatore Ulisse Eleonora Guaitoli Corrado De Vito Riccardo Caruso Renzo Mocini Vito D'Andrea Valeria Ascoli Alfredo Antonaci Carlo Catalano Francesco Nardi Adriano Redler Paolo Ricci Enrico De Antoni Salvatore Sorrenti
author_sort	Vito Cantisani
title	Q-elastography in the presurgical diagnosis of thyroid nodules with indeterminate cytology.
title_short	Q-elastography in the presurgical diagnosis of thyroid nodules with indeterminate cytology.
title_full	Q-elastography in the presurgical diagnosis of thyroid nodules with indeterminate cytology.
title_fullStr	Q-elastography in the presurgical diagnosis of thyroid nodules with indeterminate cytology.
title_full_unstemmed	Q-elastography in the presurgical diagnosis of thyroid nodules with indeterminate cytology.
title_sort	q-elastography in the presurgical diagnosis of thyroid nodules with indeterminate cytology.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/5a0698fbe97144d68f87179b23b5e960
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Q-elastography in the presurgical diagnosis of thyroid nodules with indeterminate cytology.

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