The flavonoid 4,4′-dimethoxychalcone promotes autophagy-dependent longevity across species
Although ageing is the most important risk factor for chronic ailments, effective interventions remain rare. Here, the authors identify the flavonoid 4,4’-dimethoxychalcone and demonstrate that it extends lifespan and promotes health in multiple organisms by inducing autophagy.
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Nature Portfolio
2019
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oai:doaj.org-article:5a077fc79ab04bd9a229474d374a66e52021-12-02T14:35:37ZThe flavonoid 4,4′-dimethoxychalcone promotes autophagy-dependent longevity across species10.1038/s41467-019-08555-w2041-1723https://doaj.org/article/5a077fc79ab04bd9a229474d374a66e52019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08555-whttps://doaj.org/toc/2041-1723Although ageing is the most important risk factor for chronic ailments, effective interventions remain rare. Here, the authors identify the flavonoid 4,4’-dimethoxychalcone and demonstrate that it extends lifespan and promotes health in multiple organisms by inducing autophagy.Didac Carmona-GutierrezAndreas ZimmermannKatharina KainzFederico PietrocolaGuo ChenSilvia MaglioniAlfonso SchiaviJihoon NahSara MertelChristine B. BeuschelFrancesca CastoldiValentina SicaGert TrausingerReingard RamlCornelia SommerSabrina SchroederSebastian J. HoferMaria A. BauerTobias PendlJelena TadicChristopher DammbrueckZehan HuChristoph RuckenstuhlTobias EisenbergSylvere DurandNoélie BossutFanny AprahamianMahmoud AbdellatifSimon SedejDavid P. EnotHeimo WolinskiJörn DengjelOliver KeppChristoph MagnesFrank SinnerThomas R. PieberJunichi SadoshimaNatascia VenturaStephan J. SigristGuido KroemerFrank MadeoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019) |
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DOAJ |
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EN |
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Science Q |
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Science Q Didac Carmona-Gutierrez Andreas Zimmermann Katharina Kainz Federico Pietrocola Guo Chen Silvia Maglioni Alfonso Schiavi Jihoon Nah Sara Mertel Christine B. Beuschel Francesca Castoldi Valentina Sica Gert Trausinger Reingard Raml Cornelia Sommer Sabrina Schroeder Sebastian J. Hofer Maria A. Bauer Tobias Pendl Jelena Tadic Christopher Dammbrueck Zehan Hu Christoph Ruckenstuhl Tobias Eisenberg Sylvere Durand Noélie Bossut Fanny Aprahamian Mahmoud Abdellatif Simon Sedej David P. Enot Heimo Wolinski Jörn Dengjel Oliver Kepp Christoph Magnes Frank Sinner Thomas R. Pieber Junichi Sadoshima Natascia Ventura Stephan J. Sigrist Guido Kroemer Frank Madeo The flavonoid 4,4′-dimethoxychalcone promotes autophagy-dependent longevity across species |
| description |
Although ageing is the most important risk factor for chronic ailments, effective interventions remain rare. Here, the authors identify the flavonoid 4,4’-dimethoxychalcone and demonstrate that it extends lifespan and promotes health in multiple organisms by inducing autophagy. |
| format |
article |
| author |
Didac Carmona-Gutierrez Andreas Zimmermann Katharina Kainz Federico Pietrocola Guo Chen Silvia Maglioni Alfonso Schiavi Jihoon Nah Sara Mertel Christine B. Beuschel Francesca Castoldi Valentina Sica Gert Trausinger Reingard Raml Cornelia Sommer Sabrina Schroeder Sebastian J. Hofer Maria A. Bauer Tobias Pendl Jelena Tadic Christopher Dammbrueck Zehan Hu Christoph Ruckenstuhl Tobias Eisenberg Sylvere Durand Noélie Bossut Fanny Aprahamian Mahmoud Abdellatif Simon Sedej David P. Enot Heimo Wolinski Jörn Dengjel Oliver Kepp Christoph Magnes Frank Sinner Thomas R. Pieber Junichi Sadoshima Natascia Ventura Stephan J. Sigrist Guido Kroemer Frank Madeo |
| author_facet |
Didac Carmona-Gutierrez Andreas Zimmermann Katharina Kainz Federico Pietrocola Guo Chen Silvia Maglioni Alfonso Schiavi Jihoon Nah Sara Mertel Christine B. Beuschel Francesca Castoldi Valentina Sica Gert Trausinger Reingard Raml Cornelia Sommer Sabrina Schroeder Sebastian J. Hofer Maria A. Bauer Tobias Pendl Jelena Tadic Christopher Dammbrueck Zehan Hu Christoph Ruckenstuhl Tobias Eisenberg Sylvere Durand Noélie Bossut Fanny Aprahamian Mahmoud Abdellatif Simon Sedej David P. Enot Heimo Wolinski Jörn Dengjel Oliver Kepp Christoph Magnes Frank Sinner Thomas R. Pieber Junichi Sadoshima Natascia Ventura Stephan J. Sigrist Guido Kroemer Frank Madeo |
| author_sort |
Didac Carmona-Gutierrez |
| title |
The flavonoid 4,4′-dimethoxychalcone promotes autophagy-dependent longevity across species |
| title_short |
The flavonoid 4,4′-dimethoxychalcone promotes autophagy-dependent longevity across species |
| title_full |
The flavonoid 4,4′-dimethoxychalcone promotes autophagy-dependent longevity across species |
| title_fullStr |
The flavonoid 4,4′-dimethoxychalcone promotes autophagy-dependent longevity across species |
| title_full_unstemmed |
The flavonoid 4,4′-dimethoxychalcone promotes autophagy-dependent longevity across species |
| title_sort |
flavonoid 4,4′-dimethoxychalcone promotes autophagy-dependent longevity across species |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/5a077fc79ab04bd9a229474d374a66e5 |
| work_keys_str_mv |
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