Phenotypes of prediabetes: pathogenesis and consequences for prediction and prevention of type 2 diabetes and cardiovascular diseases

The prevalence of type 2 diabetes is increasing world-wide. Thus, it is necessary to better understand its pathogenesis, the risk of diabetes-associated complications and effective treatment strategies. Because type 2 diabetes is a very heterogenous disease, both, related to its pathogenesis and ris...

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Autor principal:	Norbert Stefan
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2019
Materias:	prediabetes, diabetes mellitus type 2 profilactic cardiovascular diseases Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/5a10ac3c042c43b2ac4c81f889878add
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spelling	oai:doaj.org-article:5a10ac3c042c43b2ac4c81f889878add2021-11-14T09:00:22ZPhenotypes of prediabetes: pathogenesis and consequences for prediction and prevention of type 2 diabetes and cardiovascular diseases2072-03512072-037810.14341/DM10376https://doaj.org/article/5a10ac3c042c43b2ac4c81f889878add2019-12-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/10376https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378The prevalence of type 2 diabetes is increasing world-wide. Thus, it is necessary to better understand its pathogenesis, the risk of diabetes-associated complications and effective treatment strategies. Because type 2 diabetes is a very heterogenous disease, both, related to its pathogenesis and risk of complications, phenotyping strategies in diabetes may help to tailor the preventive strategies based on the individual’s risk. As the the hyperglycemic state of prediabetes is already associated with an increased risk of cardiometabolic diseases it is necessary to investigate the impact of phenotypes for predictive and preventive outcomes already in this early state of hyperglycemia. In this review artice I discuss how important phenotypes of prediabetes, such as nonalcoholic fatty liver disease, visceral obesity, insulin secretion defect and insulin resistance can be used to improve the prediction and prevention of type 2 diabetes and cardiovascular disease.Norbert StefanEndocrinology Research Centrearticleprediabetes, diabetes mellitus type 2profilacticcardiovascular diseasesNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 22, Iss 6, Pp 577-581 (2019)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	prediabetes, diabetes mellitus type 2 profilactic cardiovascular diseases Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	prediabetes, diabetes mellitus type 2 profilactic cardiovascular diseases Nutritional diseases. Deficiency diseases RC620-627 Norbert Stefan Phenotypes of prediabetes: pathogenesis and consequences for prediction and prevention of type 2 diabetes and cardiovascular diseases
description	The prevalence of type 2 diabetes is increasing world-wide. Thus, it is necessary to better understand its pathogenesis, the risk of diabetes-associated complications and effective treatment strategies. Because type 2 diabetes is a very heterogenous disease, both, related to its pathogenesis and risk of complications, phenotyping strategies in diabetes may help to tailor the preventive strategies based on the individual’s risk. As the the hyperglycemic state of prediabetes is already associated with an increased risk of cardiometabolic diseases it is necessary to investigate the impact of phenotypes for predictive and preventive outcomes already in this early state of hyperglycemia. In this review artice I discuss how important phenotypes of prediabetes, such as nonalcoholic fatty liver disease, visceral obesity, insulin secretion defect and insulin resistance can be used to improve the prediction and prevention of type 2 diabetes and cardiovascular disease.
format	article
author	Norbert Stefan
author_facet	Norbert Stefan
author_sort	Norbert Stefan
title	Phenotypes of prediabetes: pathogenesis and consequences for prediction and prevention of type 2 diabetes and cardiovascular diseases
title_short	Phenotypes of prediabetes: pathogenesis and consequences for prediction and prevention of type 2 diabetes and cardiovascular diseases
title_full	Phenotypes of prediabetes: pathogenesis and consequences for prediction and prevention of type 2 diabetes and cardiovascular diseases
title_fullStr	Phenotypes of prediabetes: pathogenesis and consequences for prediction and prevention of type 2 diabetes and cardiovascular diseases
title_full_unstemmed	Phenotypes of prediabetes: pathogenesis and consequences for prediction and prevention of type 2 diabetes and cardiovascular diseases
title_sort	phenotypes of prediabetes: pathogenesis and consequences for prediction and prevention of type 2 diabetes and cardiovascular diseases
publisher	Endocrinology Research Centre
publishDate	2019
url	https://doaj.org/article/5a10ac3c042c43b2ac4c81f889878add
work_keys_str_mv	AT norbertstefan phenotypesofprediabetespathogenesisandconsequencesforpredictionandpreventionoftype2diabetesandcardiovasculardiseases
_version_	1718429528819236864

Phenotypes of prediabetes: pathogenesis and consequences for prediction and prevention of type 2 diabetes and cardiovascular diseases

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