Multifunctional nanosystems: growing sanguinity in siRNA therapy

Khan Farheen Badrealam, Mohammad Owais Molecular Immunology Laboratory, Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, Uttar Pradesh, IndiaThis letter is in regards to the enlightening work published in the International Journal of Nanomedicine on multifunctional nanosyst...

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Autores principales:	Badrealam KF, Owais M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/5a10c178f0dd4d08936b4b1346071717
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spelling	oai:doaj.org-article:5a10c178f0dd4d08936b4b13460717172021-12-02T02:45:55ZMultifunctional nanosystems: growing sanguinity in siRNA therapy1178-2013https://doaj.org/article/5a10c178f0dd4d08936b4b13460717172014-04-01T00:00:00Zhttp://www.dovepress.com/efficient-downregulation-of-vegf-in-retinal-pigment-epithelletter-a16416https://doaj.org/toc/1178-2013 Khan Farheen Badrealam, Mohammad Owais Molecular Immunology Laboratory, Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, Uttar Pradesh, IndiaThis letter is in regards to the enlightening work published in the International Journal of Nanomedicine on multifunctional nanosystems developed for surmounting the stumbling blocks of small interfering ribonucleic acid (siRNA) therapeutics.1–4 These published studies make considerable advances toward realizing the great potential of RNA interference (RNAi)-based therapeutics. Despite the curability of the cause of diseases by rectifying altered functionalities of proteins, as of yet no technically viable and safe strategy has been established, owing to their various associated challenges.5 Albeit viral vectors are considered as the most promising strategy, mainly due to their high transduction efficiency and oligonucleotide packaging ability; however their widespread applicability has been marred due to various safety concerns.6 In this regard, nonviral vectors are very attractive, offering a safer alternative, but at a cost of lower transfection efficiency. However, with the advent of next generation nanoparticulate systems, multifunctional nanodelivery systems may bring newer hope to the RNAi therapeutic regimen.View original paper by Chen and colleagues.Badrealam KFOwais MDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2014, Iss Issue 1, Pp 1771-1773 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Badrealam KF Owais M Multifunctional nanosystems: growing sanguinity in siRNA therapy
description	Khan Farheen Badrealam, Mohammad Owais Molecular Immunology Laboratory, Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, Uttar Pradesh, IndiaThis letter is in regards to the enlightening work published in the International Journal of Nanomedicine on multifunctional nanosystems developed for surmounting the stumbling blocks of small interfering ribonucleic acid (siRNA) therapeutics.1–4 These published studies make considerable advances toward realizing the great potential of RNA interference (RNAi)-based therapeutics. Despite the curability of the cause of diseases by rectifying altered functionalities of proteins, as of yet no technically viable and safe strategy has been established, owing to their various associated challenges.5 Albeit viral vectors are considered as the most promising strategy, mainly due to their high transduction efficiency and oligonucleotide packaging ability; however their widespread applicability has been marred due to various safety concerns.6 In this regard, nonviral vectors are very attractive, offering a safer alternative, but at a cost of lower transfection efficiency. However, with the advent of next generation nanoparticulate systems, multifunctional nanodelivery systems may bring newer hope to the RNAi therapeutic regimen.View original paper by Chen and colleagues.
format	article
author	Badrealam KF Owais M
author_facet	Badrealam KF Owais M
author_sort	Badrealam KF
title	Multifunctional nanosystems: growing sanguinity in siRNA therapy
title_short	Multifunctional nanosystems: growing sanguinity in siRNA therapy
title_full	Multifunctional nanosystems: growing sanguinity in siRNA therapy
title_fullStr	Multifunctional nanosystems: growing sanguinity in siRNA therapy
title_full_unstemmed	Multifunctional nanosystems: growing sanguinity in siRNA therapy
title_sort	multifunctional nanosystems: growing sanguinity in sirna therapy
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/5a10c178f0dd4d08936b4b1346071717
work_keys_str_mv	AT badrealamkf multifunctionalnanosystemsgrowingsanguinityinsirnatherapy AT owaism multifunctionalnanosystemsgrowingsanguinityinsirnatherapy
_version_	1718402162315231232

Multifunctional nanosystems: growing sanguinity in siRNA therapy

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