Epidemiology and clinical findings of colorectal carcinoma in two tertiary care hospitals in Benghazi, Libya

Aim: The aim is to determine the pattern of patients with colorectal cancer (CRC) seen in two tertiary hospitals in Benghazi, Libya. Materials and methods: The cohort includes all patients of CRC who were presented between January 2007 and December 2009 to the Oncology Department, Aljomhoria Hospita...

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Autores principales:	Abdel-Naser Elzouki, Salah Habel, Saeid Alsoaeiti, Adam Abosedra, Fahmi Khan
Formato:	article
Lenguaje:	EN
Publicado:	Thieme Medical and Scientific Publishers Pvt. Ltd. 2014
Materias:	colon cancer colorectal carcinoma epidemiology libya Medicine R
Acceso en línea:	https://doaj.org/article/5a14ecbf28de4e2d8df98b02c8605c28
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spelling	oai:doaj.org-article:5a14ecbf28de4e2d8df98b02c8605c282021-12-02T16:34:19ZEpidemiology and clinical findings of colorectal carcinoma in two tertiary care hospitals in Benghazi, Libya2231-07702249-446410.4103/2231-0770.140659https://doaj.org/article/5a14ecbf28de4e2d8df98b02c8605c282014-10-01T00:00:00Zhttp://www.thieme-connect.de/DOI/DOI?10.4103/2231-0770.140659https://doaj.org/toc/2231-0770https://doaj.org/toc/2249-4464Aim: The aim is to determine the pattern of patients with colorectal cancer (CRC) seen in two tertiary hospitals in Benghazi, Libya. Materials and methods: The cohort includes all patients of CRC who were presented between January 2007 and December 2009 to the Oncology Department, Aljomhoria Hospital and 7 th October Hospital, Benghazi. Patient′s age, gender, clinical presentation, location of cancer involvement, and histopathologic diagnosis were reviewed. Tumor staging was carried out according to Astler Coller modification of Duke′s system, dividing it into stage A to C depending upon the extent of local involvement and regional node spread. Stage D was added to account for distant metastasis in accordance with Turnbull modification. Results: A total of 152 patients with CRC were included, 84 males (55%) and 68 females (45%) with a male to female ratio of 1.2:1.0. The mean age was 57.4 ± 12.92 years (range 21-87 years). 18 (11.8%) patients were below 40 years of age. The most common presenting symptoms were rectal bleeding and abdominal pain and were together present in 71% of the patients. The majority (67.8%) of tumors arise from rectum and sigmoid colon. More than one-third of the patients had poorly differentiated adenocarcinoma. Sixty patients (39.5%) presented in stage D, whereas 30.9% (47/152) and 29.6% (45/152) of patients were in stage B and stage C, respectively. None of the patients had stage A at presentation. The radiological evaluation showed presence of liver metastasis in 14 patients (9.2%) and pulmonary metastasis in two patients (1.3%). Anemia was found in 56 patients (36.8%). It was more common in females (P = 0.01) and in the right sided tumors (66.7%) than left sided tumors (29.5%) (P = 0.001). Conclusion: The majority of CRC patients in Benghazi were diagnosed in locally advanced or metastatic stage. In order to achieve early detection of CRC, a comprehensive cancer education program and screening of high risk population for CRC should be considered in this part of Libya.Abdel-Naser ElzoukiSalah HabelSaeid AlsoaeitiAdam AbosedraFahmi KhanThieme Medical and Scientific Publishers Pvt. Ltd.articlecolon cancercolorectal carcinomaepidemiologylibyaMedicineRENAvicenna Journal of Medicine, Vol 04, Iss 04, Pp 94-98 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	colon cancer colorectal carcinoma epidemiology libya Medicine R
spellingShingle	colon cancer colorectal carcinoma epidemiology libya Medicine R Abdel-Naser Elzouki Salah Habel Saeid Alsoaeiti Adam Abosedra Fahmi Khan Epidemiology and clinical findings of colorectal carcinoma in two tertiary care hospitals in Benghazi, Libya
description	Aim: The aim is to determine the pattern of patients with colorectal cancer (CRC) seen in two tertiary hospitals in Benghazi, Libya. Materials and methods: The cohort includes all patients of CRC who were presented between January 2007 and December 2009 to the Oncology Department, Aljomhoria Hospital and 7 th October Hospital, Benghazi. Patient′s age, gender, clinical presentation, location of cancer involvement, and histopathologic diagnosis were reviewed. Tumor staging was carried out according to Astler Coller modification of Duke′s system, dividing it into stage A to C depending upon the extent of local involvement and regional node spread. Stage D was added to account for distant metastasis in accordance with Turnbull modification. Results: A total of 152 patients with CRC were included, 84 males (55%) and 68 females (45%) with a male to female ratio of 1.2:1.0. The mean age was 57.4 ± 12.92 years (range 21-87 years). 18 (11.8%) patients were below 40 years of age. The most common presenting symptoms were rectal bleeding and abdominal pain and were together present in 71% of the patients. The majority (67.8%) of tumors arise from rectum and sigmoid colon. More than one-third of the patients had poorly differentiated adenocarcinoma. Sixty patients (39.5%) presented in stage D, whereas 30.9% (47/152) and 29.6% (45/152) of patients were in stage B and stage C, respectively. None of the patients had stage A at presentation. The radiological evaluation showed presence of liver metastasis in 14 patients (9.2%) and pulmonary metastasis in two patients (1.3%). Anemia was found in 56 patients (36.8%). It was more common in females (P = 0.01) and in the right sided tumors (66.7%) than left sided tumors (29.5%) (P = 0.001). Conclusion: The majority of CRC patients in Benghazi were diagnosed in locally advanced or metastatic stage. In order to achieve early detection of CRC, a comprehensive cancer education program and screening of high risk population for CRC should be considered in this part of Libya.
format	article
author	Abdel-Naser Elzouki Salah Habel Saeid Alsoaeiti Adam Abosedra Fahmi Khan
author_facet	Abdel-Naser Elzouki Salah Habel Saeid Alsoaeiti Adam Abosedra Fahmi Khan
author_sort	Abdel-Naser Elzouki
title	Epidemiology and clinical findings of colorectal carcinoma in two tertiary care hospitals in Benghazi, Libya
title_short	Epidemiology and clinical findings of colorectal carcinoma in two tertiary care hospitals in Benghazi, Libya
title_full	Epidemiology and clinical findings of colorectal carcinoma in two tertiary care hospitals in Benghazi, Libya
title_fullStr	Epidemiology and clinical findings of colorectal carcinoma in two tertiary care hospitals in Benghazi, Libya
title_full_unstemmed	Epidemiology and clinical findings of colorectal carcinoma in two tertiary care hospitals in Benghazi, Libya
title_sort	epidemiology and clinical findings of colorectal carcinoma in two tertiary care hospitals in benghazi, libya
publisher	Thieme Medical and Scientific Publishers Pvt. Ltd.
publishDate	2014
url	https://doaj.org/article/5a14ecbf28de4e2d8df98b02c8605c28
work_keys_str_mv	AT abdelnaserelzouki epidemiologyandclinicalfindingsofcolorectalcarcinomaintwotertiarycarehospitalsinbenghazilibya AT salahhabel epidemiologyandclinicalfindingsofcolorectalcarcinomaintwotertiarycarehospitalsinbenghazilibya AT saeidalsoaeiti epidemiologyandclinicalfindingsofcolorectalcarcinomaintwotertiarycarehospitalsinbenghazilibya AT adamabosedra epidemiologyandclinicalfindingsofcolorectalcarcinomaintwotertiarycarehospitalsinbenghazilibya AT fahmikhan epidemiologyandclinicalfindingsofcolorectalcarcinomaintwotertiarycarehospitalsinbenghazilibya
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Epidemiology and clinical findings of colorectal carcinoma in two tertiary care hospitals in Benghazi, Libya

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