Aberrant expression of CITED2 promotes prostate cancer metastasis by activating the nucleolin-AKT pathway

Aberrant expression of CITED2 promotes prostate cancer metastasis by activating the nucleolin-AKT pathway

More effective strategies are needed to prevent prostate cancer metastasis. Here they report CBP/p300-interacting transactivator with E/D-rich carboxy-terminal domain-2 (CITED2) to interact with nucleolin, p300, and PRMT5 subunits, and reveal a role of CITED2-nucleolin axis in prostate cancer metast...

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Autores principales: Seung-Hyun Shin, Ga Young Lee, Mingyu Lee, Jengmin Kang, Hyun-Woo Shin, Yang-Sook Chun, Jong-Wan Park
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/5a158d4c285e4d61acf6acaf921b0bb6
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spelling oai:doaj.org-article:5a158d4c285e4d61acf6acaf921b0bb62021-12-02T14:39:22ZAberrant expression of CITED2 promotes prostate cancer metastasis by activating the nucleolin-AKT pathway10.1038/s41467-018-06606-22041-1723https://doaj.org/article/5a158d4c285e4d61acf6acaf921b0bb62018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06606-2https://doaj.org/toc/2041-1723More effective strategies are needed to prevent prostate cancer metastasis. Here they report CBP/p300-interacting transactivator with E/D-rich carboxy-terminal domain-2 (CITED2) to interact with nucleolin, p300, and PRMT5 subunits, and reveal a role of CITED2-nucleolin axis in prostate cancer metastasis.Seung-Hyun ShinGa Young LeeMingyu LeeJengmin KangHyun-Woo ShinYang-Sook ChunJong-Wan ParkNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Seung-Hyun Shin
Ga Young Lee
Mingyu Lee
Jengmin Kang
Hyun-Woo Shin
Yang-Sook Chun
Jong-Wan Park
Aberrant expression of CITED2 promotes prostate cancer metastasis by activating the nucleolin-AKT pathway
description More effective strategies are needed to prevent prostate cancer metastasis. Here they report CBP/p300-interacting transactivator with E/D-rich carboxy-terminal domain-2 (CITED2) to interact with nucleolin, p300, and PRMT5 subunits, and reveal a role of CITED2-nucleolin axis in prostate cancer metastasis.
format article
author Seung-Hyun Shin
Ga Young Lee
Mingyu Lee
Jengmin Kang
Hyun-Woo Shin
Yang-Sook Chun
Jong-Wan Park
author_facet Seung-Hyun Shin
Ga Young Lee
Mingyu Lee
Jengmin Kang
Hyun-Woo Shin
Yang-Sook Chun
Jong-Wan Park
author_sort Seung-Hyun Shin
title Aberrant expression of CITED2 promotes prostate cancer metastasis by activating the nucleolin-AKT pathway
title_short Aberrant expression of CITED2 promotes prostate cancer metastasis by activating the nucleolin-AKT pathway
title_full Aberrant expression of CITED2 promotes prostate cancer metastasis by activating the nucleolin-AKT pathway
title_fullStr Aberrant expression of CITED2 promotes prostate cancer metastasis by activating the nucleolin-AKT pathway
title_full_unstemmed Aberrant expression of CITED2 promotes prostate cancer metastasis by activating the nucleolin-AKT pathway
title_sort aberrant expression of cited2 promotes prostate cancer metastasis by activating the nucleolin-akt pathway
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/5a158d4c285e4d61acf6acaf921b0bb6
work_keys_str_mv AT seunghyunshin aberrantexpressionofcited2promotesprostatecancermetastasisbyactivatingthenucleolinaktpathway
AT gayounglee aberrantexpressionofcited2promotesprostatecancermetastasisbyactivatingthenucleolinaktpathway
AT mingyulee aberrantexpressionofcited2promotesprostatecancermetastasisbyactivatingthenucleolinaktpathway
AT jengminkang aberrantexpressionofcited2promotesprostatecancermetastasisbyactivatingthenucleolinaktpathway
AT hyunwooshin aberrantexpressionofcited2promotesprostatecancermetastasisbyactivatingthenucleolinaktpathway
AT yangsookchun aberrantexpressionofcited2promotesprostatecancermetastasisbyactivatingthenucleolinaktpathway
AT jongwanpark aberrantexpressionofcited2promotesprostatecancermetastasisbyactivatingthenucleolinaktpathway
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