Structural ensemble of a glutamate transporter homologue in lipid nanodisc environment

Glutamate transporters are membrane transporters that clear the neurotransmitter L-glutamate from the synaptic cleft via a so-called elevator mechanism. Here the authors present five cryo-EM structures of the transporter homologue GltTk, which explain how substrate leakage is prevented.

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Autores principales:	Valentina Arkhipova, Albert Guskov, Dirk J. Slotboom
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5a15e2c8a0a34570bdd68f209b8447e0
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spelling	oai:doaj.org-article:5a15e2c8a0a34570bdd68f209b8447e02021-12-02T17:32:28ZStructural ensemble of a glutamate transporter homologue in lipid nanodisc environment10.1038/s41467-020-14834-82041-1723https://doaj.org/article/5a15e2c8a0a34570bdd68f209b8447e02020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14834-8https://doaj.org/toc/2041-1723Glutamate transporters are membrane transporters that clear the neurotransmitter L-glutamate from the synaptic cleft via a so-called elevator mechanism. Here the authors present five cryo-EM structures of the transporter homologue GltTk, which explain how substrate leakage is prevented.Valentina ArkhipovaAlbert GuskovDirk J. SlotboomNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Valentina Arkhipova Albert Guskov Dirk J. Slotboom Structural ensemble of a glutamate transporter homologue in lipid nanodisc environment
description	Glutamate transporters are membrane transporters that clear the neurotransmitter L-glutamate from the synaptic cleft via a so-called elevator mechanism. Here the authors present five cryo-EM structures of the transporter homologue GltTk, which explain how substrate leakage is prevented.
format	article
author	Valentina Arkhipova Albert Guskov Dirk J. Slotboom
author_facet	Valentina Arkhipova Albert Guskov Dirk J. Slotboom
author_sort	Valentina Arkhipova
title	Structural ensemble of a glutamate transporter homologue in lipid nanodisc environment
title_short	Structural ensemble of a glutamate transporter homologue in lipid nanodisc environment
title_full	Structural ensemble of a glutamate transporter homologue in lipid nanodisc environment
title_fullStr	Structural ensemble of a glutamate transporter homologue in lipid nanodisc environment
title_full_unstemmed	Structural ensemble of a glutamate transporter homologue in lipid nanodisc environment
title_sort	structural ensemble of a glutamate transporter homologue in lipid nanodisc environment
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/5a15e2c8a0a34570bdd68f209b8447e0
work_keys_str_mv	AT valentinaarkhipova structuralensembleofaglutamatetransporterhomologueinlipidnanodiscenvironment AT albertguskov structuralensembleofaglutamatetransporterhomologueinlipidnanodiscenvironment AT dirkjslotboom structuralensembleofaglutamatetransporterhomologueinlipidnanodiscenvironment
_version_	1718380311556915200

Structural ensemble of a glutamate transporter homologue in lipid nanodisc environment

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