Structural ensemble of a glutamate transporter homologue in lipid nanodisc environment

Glutamate transporters are membrane transporters that clear the neurotransmitter L-glutamate from the synaptic cleft via a so-called elevator mechanism. Here the authors present five cryo-EM structures of the transporter homologue GltTk, which explain how substrate leakage is prevented.

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Bibliographic Details
Main Authors: Valentina Arkhipova, Albert Guskov, Dirk J. Slotboom
Format: article
Language:EN
Published: Nature Portfolio 2020
Subjects:
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Online Access:https://doaj.org/article/5a15e2c8a0a34570bdd68f209b8447e0
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