Near-Infrared Laser-Triggered, Self-Immolative Smart Polymersomes for in vivo Cancer Therapy

Qing Tang,* Ping Hu,* Haibo Peng, Ning Zhang, Qiang Zheng, Yun He School of Pharmaceutical Sciences and Chongqing Key Laboratory of Natural Drug Research, Chongqing University, Chongqing 401331, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yun He...

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Autores principales:	Tang Q, Hu P, Peng H, Zhang N, Zheng Q, He Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	near infrared laser photodynamic therapy oxidation-responsive polymersome combination therapy cancer Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/5a1935f8179c4817a0f1f76a0fbd9508
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spelling	oai:doaj.org-article:5a1935f8179c4817a0f1f76a0fbd95082021-12-02T10:56:35ZNear-Infrared Laser-Triggered, Self-Immolative Smart Polymersomes for in vivo Cancer Therapy1178-2013https://doaj.org/article/5a1935f8179c4817a0f1f76a0fbd95082020-01-01T00:00:00Zhttps://www.dovepress.com/near-infrared-laser-triggered-self-immolative-smart-polymersomes-for-i-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Qing Tang,* Ping Hu,* Haibo Peng, Ning Zhang, Qiang Zheng, Yun He School of Pharmaceutical Sciences and Chongqing Key Laboratory of Natural Drug Research, Chongqing University, Chongqing 401331, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yun HeSchool of Pharmaceutical Sciences and Chongqing Key Laboratory of Natural Drug Research, Chongqing University, 55 South Daxuecheng Road, Chongqing 401331, People’s Republic of ChinaTel +86 23 6567 8450Fax +86 23 65678455Email yun.he@cqu.edu.cnPurpose: Traditional chemotherapy is accompanied by significant side effects, which, in many aspects, limits its treatment efficacy and clinical applications. Herein, we report an oxidative responsive polymersome nanosystem mediated by near infrared (NIR) light which exhibited the combination effect of photodynamic therapy (PDT) and chemotherapy.Methods: In our study, poly (propylene sulfide) 20-bl-poly (ethylene glycol) 12 (PPS 20-b-PEG 12) block copolymer was synthesized and employed to prepare the polymersome. The hydrophobic photosensitizer zinc phthalocyanine (ZnPc) was loaded in the shell and the hydrophilic doxorubicin hydrochloride (DOX·HCl) in the inner aqueous space of the polymersome.Results: Under the irradiation of 660 nm NIR light, singlet oxygen 1O 2 molecules were generated from ZnPc to oxidize the neighbouring sulfur atoms on the PPS block which eventually ruptured the intact structure of polymersomes, leading to the release of encapsulated DOX·HCl. The released DOX and the 1O 2 could achieve a combination effect for cancer therapy if the laser activation and drug release occur at the tumoral sites. In vitro studies confirmed the generation of singlet oxygen and DOX release by NIR irradiation. In vivo studies showed that such a combined PDT-chemotherapy nanosystem could accumulate in A375 tumors efficiently, thus leading to significant inhibition on tumor growth as compared to PDT (PZ group) or chemotherapy alone (DOX group).Conclusion: In summary, this oxidation-sensitive nanosystem showed excellent anti-tumor effects by synergistic chemophotodynamic therapy, indicating that this novel drug delivery strategy could potentially provide a new means for cancer treatments in clinic.Keywords: near infrared laser, photodynamic therapy, oxidation-responsive, polymersome, combination therapy, cancerTang QHu PPeng HZhang NZheng QHe YDove Medical Pressarticlenear infrared laserphotodynamic therapyoxidation-responsivepolymersomecombination therapycancerMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 137-149 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	near infrared laser photodynamic therapy oxidation-responsive polymersome combination therapy cancer Medicine (General) R5-920
spellingShingle	near infrared laser photodynamic therapy oxidation-responsive polymersome combination therapy cancer Medicine (General) R5-920 Tang Q Hu P Peng H Zhang N Zheng Q He Y Near-Infrared Laser-Triggered, Self-Immolative Smart Polymersomes for in vivo Cancer Therapy
description	Qing Tang,* Ping Hu,* Haibo Peng, Ning Zhang, Qiang Zheng, Yun He School of Pharmaceutical Sciences and Chongqing Key Laboratory of Natural Drug Research, Chongqing University, Chongqing 401331, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yun HeSchool of Pharmaceutical Sciences and Chongqing Key Laboratory of Natural Drug Research, Chongqing University, 55 South Daxuecheng Road, Chongqing 401331, People’s Republic of ChinaTel +86 23 6567 8450Fax +86 23 65678455Email yun.he@cqu.edu.cnPurpose: Traditional chemotherapy is accompanied by significant side effects, which, in many aspects, limits its treatment efficacy and clinical applications. Herein, we report an oxidative responsive polymersome nanosystem mediated by near infrared (NIR) light which exhibited the combination effect of photodynamic therapy (PDT) and chemotherapy.Methods: In our study, poly (propylene sulfide) 20-bl-poly (ethylene glycol) 12 (PPS 20-b-PEG 12) block copolymer was synthesized and employed to prepare the polymersome. The hydrophobic photosensitizer zinc phthalocyanine (ZnPc) was loaded in the shell and the hydrophilic doxorubicin hydrochloride (DOX·HCl) in the inner aqueous space of the polymersome.Results: Under the irradiation of 660 nm NIR light, singlet oxygen 1O 2 molecules were generated from ZnPc to oxidize the neighbouring sulfur atoms on the PPS block which eventually ruptured the intact structure of polymersomes, leading to the release of encapsulated DOX·HCl. The released DOX and the 1O 2 could achieve a combination effect for cancer therapy if the laser activation and drug release occur at the tumoral sites. In vitro studies confirmed the generation of singlet oxygen and DOX release by NIR irradiation. In vivo studies showed that such a combined PDT-chemotherapy nanosystem could accumulate in A375 tumors efficiently, thus leading to significant inhibition on tumor growth as compared to PDT (PZ group) or chemotherapy alone (DOX group).Conclusion: In summary, this oxidation-sensitive nanosystem showed excellent anti-tumor effects by synergistic chemophotodynamic therapy, indicating that this novel drug delivery strategy could potentially provide a new means for cancer treatments in clinic.Keywords: near infrared laser, photodynamic therapy, oxidation-responsive, polymersome, combination therapy, cancer
format	article
author	Tang Q Hu P Peng H Zhang N Zheng Q He Y
author_facet	Tang Q Hu P Peng H Zhang N Zheng Q He Y
author_sort	Tang Q
title	Near-Infrared Laser-Triggered, Self-Immolative Smart Polymersomes for in vivo Cancer Therapy
title_short	Near-Infrared Laser-Triggered, Self-Immolative Smart Polymersomes for in vivo Cancer Therapy
title_full	Near-Infrared Laser-Triggered, Self-Immolative Smart Polymersomes for in vivo Cancer Therapy
title_fullStr	Near-Infrared Laser-Triggered, Self-Immolative Smart Polymersomes for in vivo Cancer Therapy
title_full_unstemmed	Near-Infrared Laser-Triggered, Self-Immolative Smart Polymersomes for in vivo Cancer Therapy
title_sort	near-infrared laser-triggered, self-immolative smart polymersomes for in vivo cancer therapy
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/5a1935f8179c4817a0f1f76a0fbd9508
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_version_	1718396402215682048

Near-Infrared Laser-Triggered, Self-Immolative Smart Polymersomes for in vivo Cancer Therapy

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