Inflammatory Subtypes in Classic Asthma and Cough Variant Asthma

Jie Gao, Feng Wu, Sifang Wu, Xing Yang Department of Pulmonary and Critical Care Medicine, Huizhou the Third People’s Hospital, Guangzhou Medical College, Huizhou 516002, People’s Republic of ChinaCorrespondence: Sifang Wu; Xing YangHuizhou the Third People’s Hospital,...

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Autores principales:	Gao J, Wu F, Wu S, Yang X
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	cough variant asthma airway inflammatory types sputum induction bronchial hyper-responsiveness. Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/5a1afb36091548728e034d61c89e88d3
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spelling	oai:doaj.org-article:5a1afb36091548728e034d61c89e88d32021-12-02T12:51:47ZInflammatory Subtypes in Classic Asthma and Cough Variant Asthma1178-7031https://doaj.org/article/5a1afb36091548728e034d61c89e88d32020-12-01T00:00:00Zhttps://www.dovepress.com/inflammatory-subtypes-in-classic-asthma-and-cough-variant-asthma-peer-reviewed-article-JIRhttps://doaj.org/toc/1178-7031Jie Gao, Feng Wu, Sifang Wu, Xing Yang Department of Pulmonary and Critical Care Medicine, Huizhou the Third People’s Hospital, Guangzhou Medical College, Huizhou 516002, People’s Republic of ChinaCorrespondence: Sifang Wu; Xing YangHuizhou the Third People’s Hospital, Guangzhou Medical College, 1# Xuebei Ave., Huizhou, Guangdong, 516002, ChinaTel +86-13502436132; +86-13528085770Fax +86 752-2359648Email wsf197906@126.com; 87575589@qq.comBackground: Measurement of sputum is used to define airway inflammatory phenotypes. Cough variant asthma (CVA) is considered to be the initial stage of classic asthma (CA). The aim of this study was to describe the association between the different subtypes of CVA and CA.Methods: A total of 459 patients with CVA and CA were screened for the study. All included patients performed spirometry, underwent a bronchial challenge with methacholine and induced sputum according to the guidelines.Results: A higher frequency of female patients were found with CVA and the eosinophilic airway inflammation of CVA than in CA and the noneosinophilic airway inflammation of CA (p=0.004 and p=0.024, respectively). Bronchial hyper-responsiveness (BHR) was lower in eosinophilic CVA and CA (p=0.006), while no difference was found in noneosinophilic CVA and CA. Association between the percentage of sputum eosinophils and the FEV1 level fell below 20% of the baseline value (PD20) in CVA and CA (r= − 0.1245, p=0.0357 and r= − 0.2148, p=0.0014, respectively).Conclusion: Eosinophilia may be associated with more severe disease, yet there was no difference in spirometry between the eosinophilic and noneosinophilic groups, and the BHR difference was not dramatic.Keywords: cough variant asthma, airway inflammatory types, sputum induction, bronchial hyper-responsivenessGao JWu FWu SYang XDove Medical Pressarticlecough variant asthmaairway inflammatory typessputum inductionbronchial hyper-responsiveness.PathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 13, Pp 1167-1173 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	cough variant asthma airway inflammatory types sputum induction bronchial hyper-responsiveness. Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	cough variant asthma airway inflammatory types sputum induction bronchial hyper-responsiveness. Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Gao J Wu F Wu S Yang X Inflammatory Subtypes in Classic Asthma and Cough Variant Asthma
description	Jie Gao, Feng Wu, Sifang Wu, Xing Yang Department of Pulmonary and Critical Care Medicine, Huizhou the Third People’s Hospital, Guangzhou Medical College, Huizhou 516002, People’s Republic of ChinaCorrespondence: Sifang Wu; Xing YangHuizhou the Third People’s Hospital, Guangzhou Medical College, 1# Xuebei Ave., Huizhou, Guangdong, 516002, ChinaTel +86-13502436132; +86-13528085770Fax +86 752-2359648Email wsf197906@126.com; 87575589@qq.comBackground: Measurement of sputum is used to define airway inflammatory phenotypes. Cough variant asthma (CVA) is considered to be the initial stage of classic asthma (CA). The aim of this study was to describe the association between the different subtypes of CVA and CA.Methods: A total of 459 patients with CVA and CA were screened for the study. All included patients performed spirometry, underwent a bronchial challenge with methacholine and induced sputum according to the guidelines.Results: A higher frequency of female patients were found with CVA and the eosinophilic airway inflammation of CVA than in CA and the noneosinophilic airway inflammation of CA (p=0.004 and p=0.024, respectively). Bronchial hyper-responsiveness (BHR) was lower in eosinophilic CVA and CA (p=0.006), while no difference was found in noneosinophilic CVA and CA. Association between the percentage of sputum eosinophils and the FEV1 level fell below 20% of the baseline value (PD20) in CVA and CA (r= − 0.1245, p=0.0357 and r= − 0.2148, p=0.0014, respectively).Conclusion: Eosinophilia may be associated with more severe disease, yet there was no difference in spirometry between the eosinophilic and noneosinophilic groups, and the BHR difference was not dramatic.Keywords: cough variant asthma, airway inflammatory types, sputum induction, bronchial hyper-responsiveness
format	article
author	Gao J Wu F Wu S Yang X
author_facet	Gao J Wu F Wu S Yang X
author_sort	Gao J
title	Inflammatory Subtypes in Classic Asthma and Cough Variant Asthma
title_short	Inflammatory Subtypes in Classic Asthma and Cough Variant Asthma
title_full	Inflammatory Subtypes in Classic Asthma and Cough Variant Asthma
title_fullStr	Inflammatory Subtypes in Classic Asthma and Cough Variant Asthma
title_full_unstemmed	Inflammatory Subtypes in Classic Asthma and Cough Variant Asthma
title_sort	inflammatory subtypes in classic asthma and cough variant asthma
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/5a1afb36091548728e034d61c89e88d3
work_keys_str_mv	AT gaoj inflammatorysubtypesinclassicasthmaandcoughvariantasthma AT wuf inflammatorysubtypesinclassicasthmaandcoughvariantasthma AT wus inflammatorysubtypesinclassicasthmaandcoughvariantasthma AT yangx inflammatorysubtypesinclassicasthmaandcoughvariantasthma
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Inflammatory Subtypes in Classic Asthma and Cough Variant Asthma

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