Effects of Baerveldt Glaucoma Implant Surgery on Corneal Endothelial Cells of Patients with No History of Trabeculectomy

Naoki Tojo, Atsushi Hayashi, Mizuki Hamada Department of Ophthalmology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, JapanCorrespondence: Atsushi HayashiDepartment of Ophthalmology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyam...

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Autores principales:	Tojo N, Hayashi A, Hamada M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	baerveldt corneal endothelial cells anterior chamber vitreous cavity glaucoma implant surgery Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/5a1ec300c73b425480766cbf8f1bc28f
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spelling	oai:doaj.org-article:5a1ec300c73b425480766cbf8f1bc28f2021-12-02T05:23:27ZEffects of Baerveldt Glaucoma Implant Surgery on Corneal Endothelial Cells of Patients with No History of Trabeculectomy1177-5483https://doaj.org/article/5a1ec300c73b425480766cbf8f1bc28f2019-11-01T00:00:00Zhttps://www.dovepress.com/effects-of-baerveldt-glaucoma-implant-surgery-on-corneal-endothelial-c-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Naoki Tojo, Atsushi Hayashi, Mizuki Hamada Department of Ophthalmology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, JapanCorrespondence: Atsushi HayashiDepartment of Ophthalmology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama City 930-0194, JapanTel +81-76-434-7363Fax +81-76-434-5037Email ahayashi@med.u-toyama.ac.jpPurpose: Persistent corneal edema is a serious potential complication of Baerveldt glaucoma implant (BGI) surgery. A trabeculectomy reduces the density of corneal endothelial cells. We investigated the effect of BGI surgery on corneal endothelial cells of patients with no history of trabeculectomy.Methods: We retrospectively analyzed 85 eyes of 85 patients who underwent BGI surgery and were followed-up for ≥12 months. We used new criteria for surgical failure. We defined persistent corneal edema or needed additional surgery for changing the tube position due to remarkable reduction in corneal endothelial cells as failure. We compared surgical outcomes with new criteria and the rates of corneal endothelial cell density (ECD) loss after BGI surgery between the anterior chamber insertion (AC) group (n=23) and vitreous cavity insertion (VC) group (n=63).Results: The mean pre-operative ECD values of the AC and VC groups were not significantly different at 2309 ± 498 and 2204 ± 556 (p=0.426). The ECD reduction rate in the AC group was significantly faster than in the VC group. The mean post-operative IOP values significantly decreased in both groups. However, the VC group’s surgical outcomes were significantly better than the AC group’s (p=0.0241) with the new criteria.Conclusion: The mean of ECD did not decrease significantly after BGI surgery in VC group patients with no history of trabeculectomy. BGI surgery insertion to the vitreous cavity was safe and had much less effect on the ECD decrease compared to insertion to the anterior chamber.Keywords: baerveldt, corneal endothelial cells, anterior chamber, vitreous cavity, glaucoma implant surgery  Tojo NHayashi AHamada MDove Medical Pressarticlebaerveldtcorneal endothelial cellsanterior chambervitreous cavityglaucoma implant surgeryOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 13, Pp 2333-2340 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	baerveldt corneal endothelial cells anterior chamber vitreous cavity glaucoma implant surgery Ophthalmology RE1-994
spellingShingle	baerveldt corneal endothelial cells anterior chamber vitreous cavity glaucoma implant surgery Ophthalmology RE1-994 Tojo N Hayashi A Hamada M Effects of Baerveldt Glaucoma Implant Surgery on Corneal Endothelial Cells of Patients with No History of Trabeculectomy
description	Naoki Tojo, Atsushi Hayashi, Mizuki Hamada Department of Ophthalmology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, JapanCorrespondence: Atsushi HayashiDepartment of Ophthalmology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama City 930-0194, JapanTel +81-76-434-7363Fax +81-76-434-5037Email ahayashi@med.u-toyama.ac.jpPurpose: Persistent corneal edema is a serious potential complication of Baerveldt glaucoma implant (BGI) surgery. A trabeculectomy reduces the density of corneal endothelial cells. We investigated the effect of BGI surgery on corneal endothelial cells of patients with no history of trabeculectomy.Methods: We retrospectively analyzed 85 eyes of 85 patients who underwent BGI surgery and were followed-up for ≥12 months. We used new criteria for surgical failure. We defined persistent corneal edema or needed additional surgery for changing the tube position due to remarkable reduction in corneal endothelial cells as failure. We compared surgical outcomes with new criteria and the rates of corneal endothelial cell density (ECD) loss after BGI surgery between the anterior chamber insertion (AC) group (n=23) and vitreous cavity insertion (VC) group (n=63).Results: The mean pre-operative ECD values of the AC and VC groups were not significantly different at 2309 ± 498 and 2204 ± 556 (p=0.426). The ECD reduction rate in the AC group was significantly faster than in the VC group. The mean post-operative IOP values significantly decreased in both groups. However, the VC group’s surgical outcomes were significantly better than the AC group’s (p=0.0241) with the new criteria.Conclusion: The mean of ECD did not decrease significantly after BGI surgery in VC group patients with no history of trabeculectomy. BGI surgery insertion to the vitreous cavity was safe and had much less effect on the ECD decrease compared to insertion to the anterior chamber.Keywords: baerveldt, corneal endothelial cells, anterior chamber, vitreous cavity, glaucoma implant surgery
format	article
author	Tojo N Hayashi A Hamada M
author_facet	Tojo N Hayashi A Hamada M
author_sort	Tojo N
title	Effects of Baerveldt Glaucoma Implant Surgery on Corneal Endothelial Cells of Patients with No History of Trabeculectomy
title_short	Effects of Baerveldt Glaucoma Implant Surgery on Corneal Endothelial Cells of Patients with No History of Trabeculectomy
title_full	Effects of Baerveldt Glaucoma Implant Surgery on Corneal Endothelial Cells of Patients with No History of Trabeculectomy
title_fullStr	Effects of Baerveldt Glaucoma Implant Surgery on Corneal Endothelial Cells of Patients with No History of Trabeculectomy
title_full_unstemmed	Effects of Baerveldt Glaucoma Implant Surgery on Corneal Endothelial Cells of Patients with No History of Trabeculectomy
title_sort	effects of baerveldt glaucoma implant surgery on corneal endothelial cells of patients with no history of trabeculectomy
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/5a1ec300c73b425480766cbf8f1bc28f
work_keys_str_mv	AT tojon effectsofbaerveldtglaucomaimplantsurgeryoncornealendothelialcellsofpatientswithnohistoryoftrabeculectomy AT hayashia effectsofbaerveldtglaucomaimplantsurgeryoncornealendothelialcellsofpatientswithnohistoryoftrabeculectomy AT hamadam effectsofbaerveldtglaucomaimplantsurgeryoncornealendothelialcellsofpatientswithnohistoryoftrabeculectomy
_version_	1718400412094038016

Effects of Baerveldt Glaucoma Implant Surgery on Corneal Endothelial Cells of Patients with No History of Trabeculectomy

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