Histological and clinical findings in patients with post-transplantation and classical encapsulating peritoneal sclerosis: a European multicenter study.

<h4>Background</h4>Encapsulating peritoneal sclerosis (EPS) commonly presents after peritoneal dialysis has been stopped, either post-transplantation (PT-EPS) or after switching to hemodialysis (classical EPS, cEPS). The aim of the present study was to investigate whether PT-EPS and cEPS...

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Autores principales:	Joerg Latus, Sayed M Habib, Daniel Kitterer, Mario R Korte, Christoph Ulmer, Peter Fritz, Simon Davies, Mark Lambie, M Dominik Alscher, Michiel G H Betjes, Stephan Segerer, Niko Braun, European EPS study group
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5a1fae7c5e3b4488b9e8f18b32b5dcb4
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spelling	oai:doaj.org-article:5a1fae7c5e3b4488b9e8f18b32b5dcb42021-11-25T06:02:43ZHistological and clinical findings in patients with post-transplantation and classical encapsulating peritoneal sclerosis: a European multicenter study.1932-620310.1371/journal.pone.0106511https://doaj.org/article/5a1fae7c5e3b4488b9e8f18b32b5dcb42014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25171219/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Encapsulating peritoneal sclerosis (EPS) commonly presents after peritoneal dialysis has been stopped, either post-transplantation (PT-EPS) or after switching to hemodialysis (classical EPS, cEPS). The aim of the present study was to investigate whether PT-EPS and cEPS differ in morphology and clinical course.<h4>Methods</h4>In this European multicenter study we included fifty-six EPS patients, retrospectively paired-matched for peritoneal dialysis (PD) duration. Twenty-eight patients developed EPS after renal transplantation, whereas the other twenty-eight patients were classical EPS patients. Demographic data, PD details, and course of disease were documented. Peritoneal biopsies of all patients were investigated using histological criteria.<h4>Results</h4>Eighteen patients from the Netherlands and thirty-eight patients from Germany were included. Time on PD was 78(64-95) in the PT-EPS and 72(50-89) months in the cEPS group (p>0.05). There were no significant differences between the morphological findings of cEPS and PT-EPS. Podoplanin positive cells were a prominent feature in both groups, but with a similar distribution of the podoplanin patterns. Time between cessation of PD to the clinical diagnosis of EPS was significantly shorter in the PT-EPS group as compared to cEPS (4(2-9) months versus 23(7-24) months, p<0.001). Peritonitis rate was significantly higher in cEPS.<h4>Conclusions</h4>In peritoneal biopsies PT-EPS and cEPS are not distinguishable by histomorphology and immunohistochemistry, which argues against different entities. The critical phase for PT-EPS is during the first year after transplantation and therefore earlier after PD cessation then in cEPS.Joerg LatusSayed M HabibDaniel KittererMario R KorteChristoph UlmerPeter FritzSimon DaviesMark LambieM Dominik AlscherMichiel G H BetjesStephan SegererNiko BraunEuropean EPS study groupPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 8, p e106511 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Joerg Latus Sayed M Habib Daniel Kitterer Mario R Korte Christoph Ulmer Peter Fritz Simon Davies Mark Lambie M Dominik Alscher Michiel G H Betjes Stephan Segerer Niko Braun European EPS study group Histological and clinical findings in patients with post-transplantation and classical encapsulating peritoneal sclerosis: a European multicenter study.
description	<h4>Background</h4>Encapsulating peritoneal sclerosis (EPS) commonly presents after peritoneal dialysis has been stopped, either post-transplantation (PT-EPS) or after switching to hemodialysis (classical EPS, cEPS). The aim of the present study was to investigate whether PT-EPS and cEPS differ in morphology and clinical course.<h4>Methods</h4>In this European multicenter study we included fifty-six EPS patients, retrospectively paired-matched for peritoneal dialysis (PD) duration. Twenty-eight patients developed EPS after renal transplantation, whereas the other twenty-eight patients were classical EPS patients. Demographic data, PD details, and course of disease were documented. Peritoneal biopsies of all patients were investigated using histological criteria.<h4>Results</h4>Eighteen patients from the Netherlands and thirty-eight patients from Germany were included. Time on PD was 78(64-95) in the PT-EPS and 72(50-89) months in the cEPS group (p>0.05). There were no significant differences between the morphological findings of cEPS and PT-EPS. Podoplanin positive cells were a prominent feature in both groups, but with a similar distribution of the podoplanin patterns. Time between cessation of PD to the clinical diagnosis of EPS was significantly shorter in the PT-EPS group as compared to cEPS (4(2-9) months versus 23(7-24) months, p<0.001). Peritonitis rate was significantly higher in cEPS.<h4>Conclusions</h4>In peritoneal biopsies PT-EPS and cEPS are not distinguishable by histomorphology and immunohistochemistry, which argues against different entities. The critical phase for PT-EPS is during the first year after transplantation and therefore earlier after PD cessation then in cEPS.
format	article
author	Joerg Latus Sayed M Habib Daniel Kitterer Mario R Korte Christoph Ulmer Peter Fritz Simon Davies Mark Lambie M Dominik Alscher Michiel G H Betjes Stephan Segerer Niko Braun European EPS study group
author_facet	Joerg Latus Sayed M Habib Daniel Kitterer Mario R Korte Christoph Ulmer Peter Fritz Simon Davies Mark Lambie M Dominik Alscher Michiel G H Betjes Stephan Segerer Niko Braun European EPS study group
author_sort	Joerg Latus
title	Histological and clinical findings in patients with post-transplantation and classical encapsulating peritoneal sclerosis: a European multicenter study.
title_short	Histological and clinical findings in patients with post-transplantation and classical encapsulating peritoneal sclerosis: a European multicenter study.
title_full	Histological and clinical findings in patients with post-transplantation and classical encapsulating peritoneal sclerosis: a European multicenter study.
title_fullStr	Histological and clinical findings in patients with post-transplantation and classical encapsulating peritoneal sclerosis: a European multicenter study.
title_full_unstemmed	Histological and clinical findings in patients with post-transplantation and classical encapsulating peritoneal sclerosis: a European multicenter study.
title_sort	histological and clinical findings in patients with post-transplantation and classical encapsulating peritoneal sclerosis: a european multicenter study.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/5a1fae7c5e3b4488b9e8f18b32b5dcb4
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Histological and clinical findings in patients with post-transplantation and classical encapsulating peritoneal sclerosis: a European multicenter study.

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