Increased expression of peptides from non-coding genes in cancer proteomics datasets suggests potential tumor neoantigens

Rong Xiang et al. analyze the expression of non-coding genes encoded peptides in publicly-available proteomics data from five cancer types and matched controls. They identify peptides from non-coding genes including DGCR9 and RHOXF1P3 that are upregulated in tumors compared to controls, suggesting t...

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Autores principales:	Rong Xiang, Leyao Ma, Mingyu Yang, Zetian Zheng, Xiaofang Chen, Fujian Jia, Fanfan Xie, Yiming Zhou, Fuqiang Li, Kui Wu, Yafeng Zhu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/5a2014fe6a764b6aa63f10f649986208
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:5a2014fe6a764b6aa63f10f6499862082021-12-02T13:44:14ZIncreased expression of peptides from non-coding genes in cancer proteomics datasets suggests potential tumor neoantigens10.1038/s42003-021-02007-22399-3642https://doaj.org/article/5a2014fe6a764b6aa63f10f6499862082021-04-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02007-2https://doaj.org/toc/2399-3642Rong Xiang et al. analyze the expression of non-coding genes encoded peptides in publicly-available proteomics data from five cancer types and matched controls. They identify peptides from non-coding genes including DGCR9 and RHOXF1P3 that are upregulated in tumors compared to controls, suggesting that non-coding gene-encoded peptides may be a source of neoantigens in some cancers.Rong XiangLeyao MaMingyu YangZetian ZhengXiaofang ChenFujian JiaFanfan XieYiming ZhouFuqiang LiKui WuYafeng ZhuNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Rong Xiang Leyao Ma Mingyu Yang Zetian Zheng Xiaofang Chen Fujian Jia Fanfan Xie Yiming Zhou Fuqiang Li Kui Wu Yafeng Zhu Increased expression of peptides from non-coding genes in cancer proteomics datasets suggests potential tumor neoantigens
description	Rong Xiang et al. analyze the expression of non-coding genes encoded peptides in publicly-available proteomics data from five cancer types and matched controls. They identify peptides from non-coding genes including DGCR9 and RHOXF1P3 that are upregulated in tumors compared to controls, suggesting that non-coding gene-encoded peptides may be a source of neoantigens in some cancers.
format	article
author	Rong Xiang Leyao Ma Mingyu Yang Zetian Zheng Xiaofang Chen Fujian Jia Fanfan Xie Yiming Zhou Fuqiang Li Kui Wu Yafeng Zhu
author_facet	Rong Xiang Leyao Ma Mingyu Yang Zetian Zheng Xiaofang Chen Fujian Jia Fanfan Xie Yiming Zhou Fuqiang Li Kui Wu Yafeng Zhu
author_sort	Rong Xiang
title	Increased expression of peptides from non-coding genes in cancer proteomics datasets suggests potential tumor neoantigens
title_short	Increased expression of peptides from non-coding genes in cancer proteomics datasets suggests potential tumor neoantigens
title_full	Increased expression of peptides from non-coding genes in cancer proteomics datasets suggests potential tumor neoantigens
title_fullStr	Increased expression of peptides from non-coding genes in cancer proteomics datasets suggests potential tumor neoantigens
title_full_unstemmed	Increased expression of peptides from non-coding genes in cancer proteomics datasets suggests potential tumor neoantigens
title_sort	increased expression of peptides from non-coding genes in cancer proteomics datasets suggests potential tumor neoantigens
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5a2014fe6a764b6aa63f10f649986208
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Increased expression of peptides from non-coding genes in cancer proteomics datasets suggests potential tumor neoantigens

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