Association of EEG, MRI, and regional blood flow biomarkers is predictive of prodromal Alzheimer’s disease

Association of EEG, MRI, and regional blood flow biomarkers is predictive of prodromal Alzheimer’s disease

Davide Vito Moretti IRCCS S Giovanni di Dio Fatebenefratelli, Brescia, Italy Background: Thinning in the temporoparietal cortex, hippocampal atrophy, and a lower regional blood perfusion is connected with prodromal stage of Alzheimer’s disease (AD). Of note, an increase of electroencepha...

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Autor principal: Moretti DV
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2015
Materias:
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Acceso en línea:https://doaj.org/article/5a2036f2f49b497d85ec96a1ae961a4c
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spelling oai:doaj.org-article:5a2036f2f49b497d85ec96a1ae961a4c2021-12-02T07:47:21ZAssociation of EEG, MRI, and regional blood flow biomarkers is predictive of prodromal Alzheimer’s disease1178-2021https://doaj.org/article/5a2036f2f49b497d85ec96a1ae961a4c2015-10-01T00:00:00Zhttps://www.dovepress.com/association-of-eeg-mri-and-regional-blood-flow-biomarkers-is-predictiv-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Davide Vito Moretti IRCCS S Giovanni di Dio Fatebenefratelli, Brescia, Italy Background: Thinning in the temporoparietal cortex, hippocampal atrophy, and a lower regional blood perfusion is connected with prodromal stage of Alzheimer’s disease (AD). Of note, an increase of electroencephalography (EEG) upper/low alpha frequency power ratio has also been associated with these major landmarks of prodromal AD.Methods: Clinical and neuropsychological assessment, EEG recording, and high-resolution three-dimensional magnetic resonance imaging were done in 74 grown up subjects with mild cognitive impairment. This information was gathered and has been assessed 3 years postliminary. EEG recording and perfusion single-photon emission computed tomography assessment was done in 27 subjects. Alpha3/alpha2 frequency power ratio, including cortical thickness, was figured for every subject. Contrasts in cortical thickness among the groups were assessed. Pearson’s r relationship coefficient was utilized to evaluate the quality of the relationship between cortical thinning, brain perfusion, and EEG markers.Results: The higher alpha3/alpha2 frequency power ratio group corresponded with more prominent cortical decay and a lower perfusional rate in the temporoparietal cortex. In a subsequent meetup after 3 years, these patients had AD.Conclusion: High EEG upper/low alpha power ratio was connected with cortical diminishing and lower perfusion in the temporoparietal brain area. The increase in EEG upper/low alpha frequency power ratio could be helpful in recognizing people in danger of conversion to AD dementia and this may be quality information in connection with clinical assessment. Keywords: electroencephalography, mild cognitive impairment, hippocampal volume, brain rhythms, biomarkersMoretti DVDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2015, Iss default, Pp 2779-2791 (2015)
institution DOAJ
collection DOAJ
language EN
topic Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
spellingShingle Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Moretti DV
Association of EEG, MRI, and regional blood flow biomarkers is predictive of prodromal Alzheimer’s disease
description Davide Vito Moretti IRCCS S Giovanni di Dio Fatebenefratelli, Brescia, Italy Background: Thinning in the temporoparietal cortex, hippocampal atrophy, and a lower regional blood perfusion is connected with prodromal stage of Alzheimer’s disease (AD). Of note, an increase of electroencephalography (EEG) upper/low alpha frequency power ratio has also been associated with these major landmarks of prodromal AD.Methods: Clinical and neuropsychological assessment, EEG recording, and high-resolution three-dimensional magnetic resonance imaging were done in 74 grown up subjects with mild cognitive impairment. This information was gathered and has been assessed 3 years postliminary. EEG recording and perfusion single-photon emission computed tomography assessment was done in 27 subjects. Alpha3/alpha2 frequency power ratio, including cortical thickness, was figured for every subject. Contrasts in cortical thickness among the groups were assessed. Pearson’s r relationship coefficient was utilized to evaluate the quality of the relationship between cortical thinning, brain perfusion, and EEG markers.Results: The higher alpha3/alpha2 frequency power ratio group corresponded with more prominent cortical decay and a lower perfusional rate in the temporoparietal cortex. In a subsequent meetup after 3 years, these patients had AD.Conclusion: High EEG upper/low alpha power ratio was connected with cortical diminishing and lower perfusion in the temporoparietal brain area. The increase in EEG upper/low alpha frequency power ratio could be helpful in recognizing people in danger of conversion to AD dementia and this may be quality information in connection with clinical assessment. Keywords: electroencephalography, mild cognitive impairment, hippocampal volume, brain rhythms, biomarkers
format article
author Moretti DV
author_facet Moretti DV
author_sort Moretti DV
title Association of EEG, MRI, and regional blood flow biomarkers is predictive of prodromal Alzheimer’s disease
title_short Association of EEG, MRI, and regional blood flow biomarkers is predictive of prodromal Alzheimer’s disease
title_full Association of EEG, MRI, and regional blood flow biomarkers is predictive of prodromal Alzheimer’s disease
title_fullStr Association of EEG, MRI, and regional blood flow biomarkers is predictive of prodromal Alzheimer’s disease
title_full_unstemmed Association of EEG, MRI, and regional blood flow biomarkers is predictive of prodromal Alzheimer’s disease
title_sort association of eeg, mri, and regional blood flow biomarkers is predictive of prodromal alzheimer’s disease
publisher Dove Medical Press
publishDate 2015
url https://doaj.org/article/5a2036f2f49b497d85ec96a1ae961a4c
work_keys_str_mv AT morettidv associationofeegmriandregionalbloodflowbiomarkersispredictiveofprodromalalzheimerrsquosdisease
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