Neural correlates of true and false memory in mild cognitive impairment.

The goal of this research was to investigate the changes in neural processing in mild cognitive impairment. We measured phase synchrony, amplitudes, and event-related potentials in veridical and false memory to determine whether these differed in participants with mild cognitive impairment compared...

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Autores principales:	Catherine M Sweeney-Reed, Patricia M Riddell, Judi A Ellis, Jayne E Freeman, Slawomir J Nasuto
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5a20e5ab70d24627a5320009ef6f4cb5
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spelling	oai:doaj.org-article:5a20e5ab70d24627a5320009ef6f4cb52021-11-18T08:10:25ZNeural correlates of true and false memory in mild cognitive impairment.1932-620310.1371/journal.pone.0048357https://doaj.org/article/5a20e5ab70d24627a5320009ef6f4cb52012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23118992/?tool=EBIhttps://doaj.org/toc/1932-6203The goal of this research was to investigate the changes in neural processing in mild cognitive impairment. We measured phase synchrony, amplitudes, and event-related potentials in veridical and false memory to determine whether these differed in participants with mild cognitive impairment compared with typical, age-matched controls. Empirical mode decomposition phase locking analysis was used to assess synchrony, which is the first time this analysis technique has been applied in a complex cognitive task such as memory processing. The technique allowed assessment of changes in frontal and parietal cortex connectivity over time during a memory task, without a priori selection of frequency ranges, which has been shown previously to influence synchrony detection. Phase synchrony differed significantly in its timing and degree between participant groups in the theta and alpha frequency ranges. Timing differences suggested greater dependence on gist memory in the presence of mild cognitive impairment. The group with mild cognitive impairment had significantly more frontal theta phase locking than the controls in the absence of a significant behavioural difference in the task, providing new evidence for compensatory processing in the former group. Both groups showed greater frontal phase locking during false than true memory, suggesting increased searching when no actual memory trace was found. Significant inter-group differences in frontal alpha phase locking provided support for a role for lower and upper alpha oscillations in memory processing. Finally, fronto-parietal interaction was significantly reduced in the group with mild cognitive impairment, supporting the notion that mild cognitive impairment could represent an early stage in Alzheimer's disease, which has been described as a 'disconnection syndrome'.Catherine M Sweeney-ReedPatricia M RiddellJudi A EllisJayne E FreemanSlawomir J NasutoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 10, p e48357 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Catherine M Sweeney-Reed Patricia M Riddell Judi A Ellis Jayne E Freeman Slawomir J Nasuto Neural correlates of true and false memory in mild cognitive impairment.
description	The goal of this research was to investigate the changes in neural processing in mild cognitive impairment. We measured phase synchrony, amplitudes, and event-related potentials in veridical and false memory to determine whether these differed in participants with mild cognitive impairment compared with typical, age-matched controls. Empirical mode decomposition phase locking analysis was used to assess synchrony, which is the first time this analysis technique has been applied in a complex cognitive task such as memory processing. The technique allowed assessment of changes in frontal and parietal cortex connectivity over time during a memory task, without a priori selection of frequency ranges, which has been shown previously to influence synchrony detection. Phase synchrony differed significantly in its timing and degree between participant groups in the theta and alpha frequency ranges. Timing differences suggested greater dependence on gist memory in the presence of mild cognitive impairment. The group with mild cognitive impairment had significantly more frontal theta phase locking than the controls in the absence of a significant behavioural difference in the task, providing new evidence for compensatory processing in the former group. Both groups showed greater frontal phase locking during false than true memory, suggesting increased searching when no actual memory trace was found. Significant inter-group differences in frontal alpha phase locking provided support for a role for lower and upper alpha oscillations in memory processing. Finally, fronto-parietal interaction was significantly reduced in the group with mild cognitive impairment, supporting the notion that mild cognitive impairment could represent an early stage in Alzheimer's disease, which has been described as a 'disconnection syndrome'.
format	article
author	Catherine M Sweeney-Reed Patricia M Riddell Judi A Ellis Jayne E Freeman Slawomir J Nasuto
author_facet	Catherine M Sweeney-Reed Patricia M Riddell Judi A Ellis Jayne E Freeman Slawomir J Nasuto
author_sort	Catherine M Sweeney-Reed
title	Neural correlates of true and false memory in mild cognitive impairment.
title_short	Neural correlates of true and false memory in mild cognitive impairment.
title_full	Neural correlates of true and false memory in mild cognitive impairment.
title_fullStr	Neural correlates of true and false memory in mild cognitive impairment.
title_full_unstemmed	Neural correlates of true and false memory in mild cognitive impairment.
title_sort	neural correlates of true and false memory in mild cognitive impairment.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/5a20e5ab70d24627a5320009ef6f4cb5
work_keys_str_mv	AT catherinemsweeneyreed neuralcorrelatesoftrueandfalsememoryinmildcognitiveimpairment AT patriciamriddell neuralcorrelatesoftrueandfalsememoryinmildcognitiveimpairment AT judiaellis neuralcorrelatesoftrueandfalsememoryinmildcognitiveimpairment AT jayneefreeman neuralcorrelatesoftrueandfalsememoryinmildcognitiveimpairment AT slawomirjnasuto neuralcorrelatesoftrueandfalsememoryinmildcognitiveimpairment
_version_	1718422106886111232

Neural correlates of true and false memory in mild cognitive impairment.

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