Frequency of Human T-Cell Leukemia Virus Type 1 in Patients with Rare Bleeding Disorders

Background and Objective: Human T-cell leukemia virus type 1 (HTLV-1) is a virus that is endemic in some parts of the world, and as a pathogen, it can lead to severe infections in humans. Since no antiviral treatment is currently available and the only way of confrontation is prevention and identifi...

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Autores principales:	M Naderi, M Narooie-Nejad, Gh Soleimani, F Okati, H Mahmoodi Nesheli, SH Soleimanzadeh Mousavi, S Yaghoubi
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2022
Materias:	rare bleeding disorders patients human t-cell leukemia virus type 1. Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/5a260bbc2a6649d3958b448c4c858a91
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spelling	oai:doaj.org-article:5a260bbc2a6649d3958b448c4c858a912021-12-05T07:16:36ZFrequency of Human T-Cell Leukemia Virus Type 1 in Patients with Rare Bleeding Disorders1561-41072251-7170https://doaj.org/article/5a260bbc2a6649d3958b448c4c858a912022-03-01T00:00:00Zhttp://jbums.org/article-1-9882-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170Background and Objective: Human T-cell leukemia virus type 1 (HTLV-1) is a virus that is endemic in some parts of the world, and as a pathogen, it can lead to severe infections in humans. Since no antiviral treatment is currently available and the only way of confrontation is prevention and identification of infected blood, this study was performed to determine the frequency of antibodies against HTLV-1 in patients with rare bleeding disorders receiving blood in Zahedan. Methods: The study population included 180 patients with rare bleeding disorders referred to Ali Asghar Hospital in Zahedan selected by census method and 90 healthy individuals who referred to hospital lab selected by convenience sampling method in 2020. Age range was 1 to 39 years. Blood samples were collected from all participants and antibody test against HTLV-1 was confirmed using ELISA kit and positive ELISA test was confirmed using Real-time PCR. Findings: In the case group, there were 86 men (47.8%) and 94 women (52.2%) and in the control group there were 43 men (47.8%) and 47 women (52.2%). Antibodies against HTLV-1 were found in 2 patients (1.1%) with rare bleeding disorders and none in healthy individuals. The first was a 29-year-old man with Glanzmann's disease who had severe Glanzmann's thrombasthenia. The second case was a 23-year-old woman with severe forms of factor V and factor VIII deficiency whose family history of Rare Bleeding Disorders (RBD) was positive. Conclusion: The results of the study showed that the risk of HTLV-1 transmission through plasma-induced blood products and new types of coagulation factors seems negligible.M NaderiM Narooie-NejadGh SoleimaniF OkatiH Mahmoodi NesheliSH Soleimanzadeh MousaviS YaghoubiBabol University of Medical Sciencesarticlerare bleeding disorderspatientshuman t-cell leukemia virus type 1.MedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 24, Iss 1, Pp 10-17 (2022)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	rare bleeding disorders patients human t-cell leukemia virus type 1. Medicine R Medicine (General) R5-920
spellingShingle	rare bleeding disorders patients human t-cell leukemia virus type 1. Medicine R Medicine (General) R5-920 M Naderi M Narooie-Nejad Gh Soleimani F Okati H Mahmoodi Nesheli SH Soleimanzadeh Mousavi S Yaghoubi Frequency of Human T-Cell Leukemia Virus Type 1 in Patients with Rare Bleeding Disorders
description	Background and Objective: Human T-cell leukemia virus type 1 (HTLV-1) is a virus that is endemic in some parts of the world, and as a pathogen, it can lead to severe infections in humans. Since no antiviral treatment is currently available and the only way of confrontation is prevention and identification of infected blood, this study was performed to determine the frequency of antibodies against HTLV-1 in patients with rare bleeding disorders receiving blood in Zahedan. Methods: The study population included 180 patients with rare bleeding disorders referred to Ali Asghar Hospital in Zahedan selected by census method and 90 healthy individuals who referred to hospital lab selected by convenience sampling method in 2020. Age range was 1 to 39 years. Blood samples were collected from all participants and antibody test against HTLV-1 was confirmed using ELISA kit and positive ELISA test was confirmed using Real-time PCR. Findings: In the case group, there were 86 men (47.8%) and 94 women (52.2%) and in the control group there were 43 men (47.8%) and 47 women (52.2%). Antibodies against HTLV-1 were found in 2 patients (1.1%) with rare bleeding disorders and none in healthy individuals. The first was a 29-year-old man with Glanzmann's disease who had severe Glanzmann's thrombasthenia. The second case was a 23-year-old woman with severe forms of factor V and factor VIII deficiency whose family history of Rare Bleeding Disorders (RBD) was positive. Conclusion: The results of the study showed that the risk of HTLV-1 transmission through plasma-induced blood products and new types of coagulation factors seems negligible.
format	article
author	M Naderi M Narooie-Nejad Gh Soleimani F Okati H Mahmoodi Nesheli SH Soleimanzadeh Mousavi S Yaghoubi
author_facet	M Naderi M Narooie-Nejad Gh Soleimani F Okati H Mahmoodi Nesheli SH Soleimanzadeh Mousavi S Yaghoubi
author_sort	M Naderi
title	Frequency of Human T-Cell Leukemia Virus Type 1 in Patients with Rare Bleeding Disorders
title_short	Frequency of Human T-Cell Leukemia Virus Type 1 in Patients with Rare Bleeding Disorders
title_full	Frequency of Human T-Cell Leukemia Virus Type 1 in Patients with Rare Bleeding Disorders
title_fullStr	Frequency of Human T-Cell Leukemia Virus Type 1 in Patients with Rare Bleeding Disorders
title_full_unstemmed	Frequency of Human T-Cell Leukemia Virus Type 1 in Patients with Rare Bleeding Disorders
title_sort	frequency of human t-cell leukemia virus type 1 in patients with rare bleeding disorders
publisher	Babol University of Medical Sciences
publishDate	2022
url	https://doaj.org/article/5a260bbc2a6649d3958b448c4c858a91
work_keys_str_mv	AT mnaderi frequencyofhumantcellleukemiavirustype1inpatientswithrarebleedingdisorders AT mnarooienejad frequencyofhumantcellleukemiavirustype1inpatientswithrarebleedingdisorders AT ghsoleimani frequencyofhumantcellleukemiavirustype1inpatientswithrarebleedingdisorders AT fokati frequencyofhumantcellleukemiavirustype1inpatientswithrarebleedingdisorders AT hmahmoodinesheli frequencyofhumantcellleukemiavirustype1inpatientswithrarebleedingdisorders AT shsoleimanzadehmousavi frequencyofhumantcellleukemiavirustype1inpatientswithrarebleedingdisorders AT syaghoubi frequencyofhumantcellleukemiavirustype1inpatientswithrarebleedingdisorders
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Frequency of Human T-Cell Leukemia Virus Type 1 in Patients with Rare Bleeding Disorders

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