TRPML1 links lysosomal calcium to autophagosome biogenesis through the activation of the CaMKKβ/VPS34 pathway

TRPML1 links lysosomal calcium to autophagosome biogenesis through the activation of the CaMKKβ/VPS34 pathway

It was known that prolonged TRMPL1 activation induces TFEB translocation and upregulates autophagic gene regulation. Here, the authors show that acute TRMPL1 activation also induces autophagy through VPS34 and by lysosomal calcium release independent of TFEB.

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Detalles Bibliográficos
Autores principales: A. Scotto Rosato, S. Montefusco, C. Soldati, S. Di Paola, A. Capuozzo, J. Monfregola, E. Polishchuk, A. Amabile, C. Grimm, A. Lombardo, M. A. De Matteis, A. Ballabio, D. L. Medina
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/5a263f04aa804d09a04f8792598c3169
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Descripción
Sumario:It was known that prolonged TRMPL1 activation induces TFEB translocation and upregulates autophagic gene regulation. Here, the authors show that acute TRMPL1 activation also induces autophagy through VPS34 and by lysosomal calcium release independent of TFEB.

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