TRPML1 links lysosomal calcium to autophagosome biogenesis through the activation of the CaMKKβ/VPS34 pathway

It was known that prolonged TRMPL1 activation induces TFEB translocation and upregulates autophagic gene regulation. Here, the authors show that acute TRMPL1 activation also induces autophagy through VPS34 and by lysosomal calcium release independent of TFEB.

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Autores principales:	A. Scotto Rosato, S. Montefusco, C. Soldati, S. Di Paola, A. Capuozzo, J. Monfregola, E. Polishchuk, A. Amabile, C. Grimm, A. Lombardo, M. A. De Matteis, A. Ballabio, D. L. Medina
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5a263f04aa804d09a04f8792598c3169
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spelling	oai:doaj.org-article:5a263f04aa804d09a04f8792598c31692021-12-02T16:58:04ZTRPML1 links lysosomal calcium to autophagosome biogenesis through the activation of the CaMKKβ/VPS34 pathway10.1038/s41467-019-13572-w2041-1723https://doaj.org/article/5a263f04aa804d09a04f8792598c31692019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13572-whttps://doaj.org/toc/2041-1723It was known that prolonged TRMPL1 activation induces TFEB translocation and upregulates autophagic gene regulation. Here, the authors show that acute TRMPL1 activation also induces autophagy through VPS34 and by lysosomal calcium release independent of TFEB.A. Scotto RosatoS. MontefuscoC. SoldatiS. Di PaolaA. CapuozzoJ. MonfregolaE. PolishchukA. AmabileC. GrimmA. LombardoM. A. De MatteisA. BallabioD. L. MedinaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q A. Scotto Rosato S. Montefusco C. Soldati S. Di Paola A. Capuozzo J. Monfregola E. Polishchuk A. Amabile C. Grimm A. Lombardo M. A. De Matteis A. Ballabio D. L. Medina TRPML1 links lysosomal calcium to autophagosome biogenesis through the activation of the CaMKKβ/VPS34 pathway
description	It was known that prolonged TRMPL1 activation induces TFEB translocation and upregulates autophagic gene regulation. Here, the authors show that acute TRMPL1 activation also induces autophagy through VPS34 and by lysosomal calcium release independent of TFEB.
format	article
author	A. Scotto Rosato S. Montefusco C. Soldati S. Di Paola A. Capuozzo J. Monfregola E. Polishchuk A. Amabile C. Grimm A. Lombardo M. A. De Matteis A. Ballabio D. L. Medina
author_facet	A. Scotto Rosato S. Montefusco C. Soldati S. Di Paola A. Capuozzo J. Monfregola E. Polishchuk A. Amabile C. Grimm A. Lombardo M. A. De Matteis A. Ballabio D. L. Medina
author_sort	A. Scotto Rosato
title	TRPML1 links lysosomal calcium to autophagosome biogenesis through the activation of the CaMKKβ/VPS34 pathway
title_short	TRPML1 links lysosomal calcium to autophagosome biogenesis through the activation of the CaMKKβ/VPS34 pathway
title_full	TRPML1 links lysosomal calcium to autophagosome biogenesis through the activation of the CaMKKβ/VPS34 pathway
title_fullStr	TRPML1 links lysosomal calcium to autophagosome biogenesis through the activation of the CaMKKβ/VPS34 pathway
title_full_unstemmed	TRPML1 links lysosomal calcium to autophagosome biogenesis through the activation of the CaMKKβ/VPS34 pathway
title_sort	trpml1 links lysosomal calcium to autophagosome biogenesis through the activation of the camkkβ/vps34 pathway
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/5a263f04aa804d09a04f8792598c3169
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TRPML1 links lysosomal calcium to autophagosome biogenesis through the activation of the CaMKKβ/VPS34 pathway

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