Use of Lipid-Lowering Drugs and Associated Outcomes According to Health State Profiles in Hospitalized Older Patients
Carlotta Franchi,1 Giulia Lancellotti,2 Marco Bertolotti,2 Simona Di Salvatore,2 Alessandro Nobili,1 Pier Mannuccio Mannucci,3 Chiara Mussi,2,* Ilaria Ardoino1,* On Behalf of the REPOSI (REgistro POliterapie SIMI and Società Italiana di Medicina Interna) Study Group1Department of Neu...
Guardado en:
| Autores principales: | , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Dove Medical Press
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/5a298ee78cc34f9faa91453ef58b299e |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:5a298ee78cc34f9faa91453ef58b299e |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:5a298ee78cc34f9faa91453ef58b299e2021-12-02T16:32:14ZUse of Lipid-Lowering Drugs and Associated Outcomes According to Health State Profiles in Hospitalized Older Patients1178-1998https://doaj.org/article/5a298ee78cc34f9faa91453ef58b299e2021-07-01T00:00:00Zhttps://www.dovepress.com/use-of-lipid-lowering-drugs-and-associated-outcomes-according-to-healt-peer-reviewed-fulltext-article-CIAhttps://doaj.org/toc/1178-1998Carlotta Franchi,1 Giulia Lancellotti,2 Marco Bertolotti,2 Simona Di Salvatore,2 Alessandro Nobili,1 Pier Mannuccio Mannucci,3 Chiara Mussi,2,* Ilaria Ardoino1,* On Behalf of the REPOSI (REgistro POliterapie SIMI and Società Italiana di Medicina Interna) Study Group1Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milano, Italy; 2Division of Geriatrics, Department of Biomedical, metabolic and Neural Sciences and Center for Gerontological Evaluation and Research, Università di Modena e Reggio Emilia, Modena, Italy; 3Scientific Direction, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milano, Italy*These authors contributed equally to this workCorrespondence: Carlotta FranchiUnit of Pharmacoepidemiological Research in Older People, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Mario Negri 2, Milano, 20156, ItalyTel +39 02 39014580Fax +39 02 39001916Email carlotta.franchi@marionegri.itObjective: To assess how lipid-lowering drugs (LLDs) are administered in the hospitalized patients aged 65 and older and their association with clinical outcomes according to their health-related profiles.Design: This is a retrospective study based on data from REPOSI (REgistro POliterapie SIMI – Italian Society of Internal Medicine) register, an Italian network of internal medicine hospital wards.Setting and Participants: A total of 4642 patients with a mean age of 79 years enrolled between 2010 and 2018.Methods: Socio-demographic characteristics, functional abilities, cognitive skills, laboratory parameters and comorbidities were used to investigate the health state profiles by using multiple correspondence analysis and clustering. Logistic regression was used to assess whether LLD prescription was associated with patients’ health state profiles and with short-term mortality.Results: Four clusters of patients were identified according to their health state: two of them (Cluster III and IV) were the epitome of frailty conditions with poor short-term outcomes, whereas the others included healthier patients. The average prevalence of LLD use was 27.6%. The lowest prevalence was found among the healthier patients in Cluster I and among the oldest frail patients with severe functional and cognitive impairment in Cluster IV. The highest prevalence was among multimorbid patients in Cluster III (OR=4.50, 95% CI=3.76– 5.38) characterized by a high cardiovascular risk. Being prescribed with LLDs was associated with a lower 3-month mortality, even after adjusting for cluster assignment (OR=0.59; 95% CI = 0.44– 0.80).Conclusion: The prevalence of LLD prescription was low and in overall agreement with guideline recommendations and with respect to patients’ health state profiles.Keywords: statins, health state profile, multimorbidity, polypharmacyFranchi CLancellotti GBertolotti MDi Salvatore SNobili AMannucci PMMussi CArdoino IDove Medical Pressarticlestatinshealth state profilemultimorbiditypolypharmacyGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 16, Pp 1251-1264 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
statins health state profile multimorbidity polypharmacy Geriatrics RC952-954.6 |
| spellingShingle |
statins health state profile multimorbidity polypharmacy Geriatrics RC952-954.6 Franchi C Lancellotti G Bertolotti M Di Salvatore S Nobili A Mannucci PM Mussi C Ardoino I Use of Lipid-Lowering Drugs and Associated Outcomes According to Health State Profiles in Hospitalized Older Patients |
| description |
Carlotta Franchi,1 Giulia Lancellotti,2 Marco Bertolotti,2 Simona Di Salvatore,2 Alessandro Nobili,1 Pier Mannuccio Mannucci,3 Chiara Mussi,2,* Ilaria Ardoino1,* On Behalf of the REPOSI (REgistro POliterapie SIMI and Società Italiana di Medicina Interna) Study Group1Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milano, Italy; 2Division of Geriatrics, Department of Biomedical, metabolic and Neural Sciences and Center for Gerontological Evaluation and Research, Università di Modena e Reggio Emilia, Modena, Italy; 3Scientific Direction, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milano, Italy*These authors contributed equally to this workCorrespondence: Carlotta FranchiUnit of Pharmacoepidemiological Research in Older People, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Mario Negri 2, Milano, 20156, ItalyTel +39 02 39014580Fax +39 02 39001916Email carlotta.franchi@marionegri.itObjective: To assess how lipid-lowering drugs (LLDs) are administered in the hospitalized patients aged 65 and older and their association with clinical outcomes according to their health-related profiles.Design: This is a retrospective study based on data from REPOSI (REgistro POliterapie SIMI – Italian Society of Internal Medicine) register, an Italian network of internal medicine hospital wards.Setting and Participants: A total of 4642 patients with a mean age of 79 years enrolled between 2010 and 2018.Methods: Socio-demographic characteristics, functional abilities, cognitive skills, laboratory parameters and comorbidities were used to investigate the health state profiles by using multiple correspondence analysis and clustering. Logistic regression was used to assess whether LLD prescription was associated with patients’ health state profiles and with short-term mortality.Results: Four clusters of patients were identified according to their health state: two of them (Cluster III and IV) were the epitome of frailty conditions with poor short-term outcomes, whereas the others included healthier patients. The average prevalence of LLD use was 27.6%. The lowest prevalence was found among the healthier patients in Cluster I and among the oldest frail patients with severe functional and cognitive impairment in Cluster IV. The highest prevalence was among multimorbid patients in Cluster III (OR=4.50, 95% CI=3.76– 5.38) characterized by a high cardiovascular risk. Being prescribed with LLDs was associated with a lower 3-month mortality, even after adjusting for cluster assignment (OR=0.59; 95% CI = 0.44– 0.80).Conclusion: The prevalence of LLD prescription was low and in overall agreement with guideline recommendations and with respect to patients’ health state profiles.Keywords: statins, health state profile, multimorbidity, polypharmacy |
| format |
article |
| author |
Franchi C Lancellotti G Bertolotti M Di Salvatore S Nobili A Mannucci PM Mussi C Ardoino I |
| author_facet |
Franchi C Lancellotti G Bertolotti M Di Salvatore S Nobili A Mannucci PM Mussi C Ardoino I |
| author_sort |
Franchi C |
| title |
Use of Lipid-Lowering Drugs and Associated Outcomes According to Health State Profiles in Hospitalized Older Patients |
| title_short |
Use of Lipid-Lowering Drugs and Associated Outcomes According to Health State Profiles in Hospitalized Older Patients |
| title_full |
Use of Lipid-Lowering Drugs and Associated Outcomes According to Health State Profiles in Hospitalized Older Patients |
| title_fullStr |
Use of Lipid-Lowering Drugs and Associated Outcomes According to Health State Profiles in Hospitalized Older Patients |
| title_full_unstemmed |
Use of Lipid-Lowering Drugs and Associated Outcomes According to Health State Profiles in Hospitalized Older Patients |
| title_sort |
use of lipid-lowering drugs and associated outcomes according to health state profiles in hospitalized older patients |
| publisher |
Dove Medical Press |
| publishDate |
2021 |
| url |
https://doaj.org/article/5a298ee78cc34f9faa91453ef58b299e |
| work_keys_str_mv |
AT franchic useoflipidloweringdrugsandassociatedoutcomesaccordingtohealthstateprofilesinhospitalizedolderpatients AT lancellottig useoflipidloweringdrugsandassociatedoutcomesaccordingtohealthstateprofilesinhospitalizedolderpatients AT bertolottim useoflipidloweringdrugsandassociatedoutcomesaccordingtohealthstateprofilesinhospitalizedolderpatients AT disalvatores useoflipidloweringdrugsandassociatedoutcomesaccordingtohealthstateprofilesinhospitalizedolderpatients AT nobilia useoflipidloweringdrugsandassociatedoutcomesaccordingtohealthstateprofilesinhospitalizedolderpatients AT mannuccipm useoflipidloweringdrugsandassociatedoutcomesaccordingtohealthstateprofilesinhospitalizedolderpatients AT mussic useoflipidloweringdrugsandassociatedoutcomesaccordingtohealthstateprofilesinhospitalizedolderpatients AT ardoinoi useoflipidloweringdrugsandassociatedoutcomesaccordingtohealthstateprofilesinhospitalizedolderpatients |
| _version_ |
1718383809854963712 |