Profiling trait anxiety: transcriptome analysis reveals cathepsin B (Ctsb) as a novel candidate gene for emotionality in mice.

Profiling trait anxiety: transcriptome analysis reveals cathepsin B (Ctsb) as a novel candidate gene for emotionality in mice.

Behavioral endophenotypes are determined by a multitude of counteracting but precisely balanced molecular and physiological mechanisms. In this study, we aim to identify potential novel molecular targets that contribute to the multigenic trait "anxiety". We used microarrays to investigate...

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Main Authors: Ludwig Czibere, Laura A Baur, Anke Wittmann, Katja Gemmeke, Andrea Steiner, Peter Weber, Benno Pütz, Nafees Ahmad, Mirjam Bunck, Cornelia Graf, Regina Widner, Claudia Kühne, Markus Panhuysen, Boris Hambsch, Gabriele Rieder, Thomas Reinheckel, Christoph Peters, Florian Holsboer, Rainer Landgraf, Jan M Deussing
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2011
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/5a2ad2e33cd54f34a13d737be0d182ea
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