Memory deficit in patients with schizophrenia and posttraumatic stress disorder: relational vs item-specific memory

Wookyoung Jung,1 Seung-Hwan Lee1,2 1Clinical Emotions and Cognition Research Laboratory, Department of Psychiatry, Inje University, Ilsan-Paik Hospital, 2Department of Psychiatry, Inje University, Ilsan-Paik Hospital, Goyang, Korea Abstract: It has been well established that patients with schizoph...

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Autores principales:	Jung W, Lee SH
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	episodic memory deficit schizophrenia post-traumatic stress disorder relational memory item-specific memory Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/5a2bb7f91bd14de0a3f71ac87444e281
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spelling	oai:doaj.org-article:5a2bb7f91bd14de0a3f71ac87444e2812021-12-02T02:36:08ZMemory deficit in patients with schizophrenia and posttraumatic stress disorder: relational vs item-specific memory1178-2021https://doaj.org/article/5a2bb7f91bd14de0a3f71ac87444e2812016-05-01T00:00:00Zhttps://www.dovepress.com/memory-deficit-in-patients-with-schizophrenia-and-posttraumatic-stress-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Wookyoung Jung,1 Seung-Hwan Lee1,2 1Clinical Emotions and Cognition Research Laboratory, Department of Psychiatry, Inje University, Ilsan-Paik Hospital, 2Department of Psychiatry, Inje University, Ilsan-Paik Hospital, Goyang, Korea Abstract: It has been well established that patients with schizophrenia have impairments in cognitive functioning and also that patients who experienced traumatic events suffer from cognitive deficits. Of the cognitive deficits revealed in schizophrenia or posttraumatic stress disorder (PTSD) patients, the current article provides a brief review of deficit in episodic memory, which is highly predictive of patients’ quality of life and global functioning. In particular, we have focused on studies that compared relational and item-specific memory performance in schizophrenia and PTSD, because measures of relational and item-specific memory are considered the most promising constructs for immediate tangible development of clinical trial paradigm. The behavioral findings of schizophrenia are based on the tasks developed by the Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia (CNTRICS) initiative and the Cognitive Neuroscience Test Reliability and Clinical Applications for Schizophrenia (CNTRACS) Consortium. The findings we reviewed consistently showed that schizophrenia and PTSD are closely associated with more severe impairments in relational memory compared to item-specific memory. Candidate brain regions involved in relational memory impairment in schizophrenia and PTSD are also discussed. Keywords: schizophrenia, posttraumatic stress disorder, episodic memory deficit, relational memory, item-specific memory, prefrontal cortex, hippocampusJung WLee SHDove Medical Pressarticleepisodic memory deficitschizophreniapost-traumatic stress disorderrelational memoryitem-specific memoryNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2016, Iss Issue 1, Pp 1157-1166 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	episodic memory deficit schizophrenia post-traumatic stress disorder relational memory item-specific memory Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	episodic memory deficit schizophrenia post-traumatic stress disorder relational memory item-specific memory Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Jung W Lee SH Memory deficit in patients with schizophrenia and posttraumatic stress disorder: relational vs item-specific memory
description	Wookyoung Jung,1 Seung-Hwan Lee1,2 1Clinical Emotions and Cognition Research Laboratory, Department of Psychiatry, Inje University, Ilsan-Paik Hospital, 2Department of Psychiatry, Inje University, Ilsan-Paik Hospital, Goyang, Korea Abstract: It has been well established that patients with schizophrenia have impairments in cognitive functioning and also that patients who experienced traumatic events suffer from cognitive deficits. Of the cognitive deficits revealed in schizophrenia or posttraumatic stress disorder (PTSD) patients, the current article provides a brief review of deficit in episodic memory, which is highly predictive of patients’ quality of life and global functioning. In particular, we have focused on studies that compared relational and item-specific memory performance in schizophrenia and PTSD, because measures of relational and item-specific memory are considered the most promising constructs for immediate tangible development of clinical trial paradigm. The behavioral findings of schizophrenia are based on the tasks developed by the Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia (CNTRICS) initiative and the Cognitive Neuroscience Test Reliability and Clinical Applications for Schizophrenia (CNTRACS) Consortium. The findings we reviewed consistently showed that schizophrenia and PTSD are closely associated with more severe impairments in relational memory compared to item-specific memory. Candidate brain regions involved in relational memory impairment in schizophrenia and PTSD are also discussed. Keywords: schizophrenia, posttraumatic stress disorder, episodic memory deficit, relational memory, item-specific memory, prefrontal cortex, hippocampus
format	article
author	Jung W Lee SH
author_facet	Jung W Lee SH
author_sort	Jung W
title	Memory deficit in patients with schizophrenia and posttraumatic stress disorder: relational vs item-specific memory
title_short	Memory deficit in patients with schizophrenia and posttraumatic stress disorder: relational vs item-specific memory
title_full	Memory deficit in patients with schizophrenia and posttraumatic stress disorder: relational vs item-specific memory
title_fullStr	Memory deficit in patients with schizophrenia and posttraumatic stress disorder: relational vs item-specific memory
title_full_unstemmed	Memory deficit in patients with schizophrenia and posttraumatic stress disorder: relational vs item-specific memory
title_sort	memory deficit in patients with schizophrenia and posttraumatic stress disorder: relational vs item-specific memory
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/5a2bb7f91bd14de0a3f71ac87444e281
work_keys_str_mv	AT jungw memorydeficitinpatientswithschizophreniaandposttraumaticstressdisorderrelationalvsitemspecificmemory AT leesh memorydeficitinpatientswithschizophreniaandposttraumaticstressdisorderrelationalvsitemspecificmemory
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Memory deficit in patients with schizophrenia and posttraumatic stress disorder: relational vs item-specific memory

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