Frizzled receptors (FZD) play multiple cellular roles in development, in diseases, and as potential therapeutic targets

Frizzled receptors (FZDs) are 7-pass transmembrane proteins and members of the G protein-coupled receptor (GPCRs) superfamily. They are classified as WNT receptors and show specific and dynamic expression during different embryonic development stages of invertebrates and vertebrates. They are requir...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autor principal:	Abdulmajeed F. Alrefaei
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Frizzled FZD Wnt signaling Development Cancer Neurodegenerative disorders Science (General) Q1-390
Acceso en línea:	https://doaj.org/article/5a2c2012953f47a4857bac7c050f1499
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5a2c2012953f47a4857bac7c050f1499
record_format	dspace
spelling	oai:doaj.org-article:5a2c2012953f47a4857bac7c050f14992021-11-18T04:44:05ZFrizzled receptors (FZD) play multiple cellular roles in development, in diseases, and as potential therapeutic targets1018-364710.1016/j.jksus.2021.101613https://doaj.org/article/5a2c2012953f47a4857bac7c050f14992021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1018364721002755https://doaj.org/toc/1018-3647Frizzled receptors (FZDs) are 7-pass transmembrane proteins and members of the G protein-coupled receptor (GPCRs) superfamily. They are classified as WNT receptors and show specific and dynamic expression during different embryonic development stages of invertebrates and vertebrates. They are required in the regulation of developmental processes such as cell specification, cell polarity, and neural patterning in Drosophila, zebrafish, Xenopus, mice, humans, and other animals. The dysfunction of FZDs causes several diseases, including cancer, neural tube defects, and neural degeneration. This review focuses on the structure, signaling, and WNT binding specificity of FZDs as well as their roles in development and diseases, including cancer, embryonic defects, and neurodegenerative disorders. Furthermore, the use of FZDs as potential therapeutic targets for various human diseases is discussed.Abdulmajeed F. AlrefaeiElsevierarticleFrizzledFZDWnt signalingDevelopmentCancerNeurodegenerative disordersScience (General)Q1-390ENJournal of King Saud University: Science, Vol 33, Iss 8, Pp 101613- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Frizzled FZD Wnt signaling Development Cancer Neurodegenerative disorders Science (General) Q1-390
spellingShingle	Frizzled FZD Wnt signaling Development Cancer Neurodegenerative disorders Science (General) Q1-390 Abdulmajeed F. Alrefaei Frizzled receptors (FZD) play multiple cellular roles in development, in diseases, and as potential therapeutic targets
description	Frizzled receptors (FZDs) are 7-pass transmembrane proteins and members of the G protein-coupled receptor (GPCRs) superfamily. They are classified as WNT receptors and show specific and dynamic expression during different embryonic development stages of invertebrates and vertebrates. They are required in the regulation of developmental processes such as cell specification, cell polarity, and neural patterning in Drosophila, zebrafish, Xenopus, mice, humans, and other animals. The dysfunction of FZDs causes several diseases, including cancer, neural tube defects, and neural degeneration. This review focuses on the structure, signaling, and WNT binding specificity of FZDs as well as their roles in development and diseases, including cancer, embryonic defects, and neurodegenerative disorders. Furthermore, the use of FZDs as potential therapeutic targets for various human diseases is discussed.
format	article
author	Abdulmajeed F. Alrefaei
author_facet	Abdulmajeed F. Alrefaei
author_sort	Abdulmajeed F. Alrefaei
title	Frizzled receptors (FZD) play multiple cellular roles in development, in diseases, and as potential therapeutic targets
title_short	Frizzled receptors (FZD) play multiple cellular roles in development, in diseases, and as potential therapeutic targets
title_full	Frizzled receptors (FZD) play multiple cellular roles in development, in diseases, and as potential therapeutic targets
title_fullStr	Frizzled receptors (FZD) play multiple cellular roles in development, in diseases, and as potential therapeutic targets
title_full_unstemmed	Frizzled receptors (FZD) play multiple cellular roles in development, in diseases, and as potential therapeutic targets
title_sort	frizzled receptors (fzd) play multiple cellular roles in development, in diseases, and as potential therapeutic targets
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/5a2c2012953f47a4857bac7c050f1499
work_keys_str_mv	AT abdulmajeedfalrefaei frizzledreceptorsfzdplaymultiplecellularrolesindevelopmentindiseasesandaspotentialtherapeutictargets
_version_	1718425101391626240

Frizzled receptors (FZD) play multiple cellular roles in development, in diseases, and as potential therapeutic targets

Ejemplares similares