Target preference of Type III-A CRISPR-Cas complexes at the transcription bubble

Type III CRISPR-Cas systems are able to target transcriptionally active DNA sequences in phages and plasmids. Here, the authors reveal the mechanism of the target nucleic acid preference of Type III-A CRISPR-Cas complexes at the transcription bubble by a combination of structural and biochemical app...

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Autores principales:	Tina Y. Liu, Jun-Jie Liu, Abhishek J. Aditham, Eva Nogales, Jennifer A. Doudna
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5a2efd0e054746c6934bd0d016c53fc2
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spelling	oai:doaj.org-article:5a2efd0e054746c6934bd0d016c53fc22021-12-02T15:35:30ZTarget preference of Type III-A CRISPR-Cas complexes at the transcription bubble10.1038/s41467-019-10780-22041-1723https://doaj.org/article/5a2efd0e054746c6934bd0d016c53fc22019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10780-2https://doaj.org/toc/2041-1723Type III CRISPR-Cas systems are able to target transcriptionally active DNA sequences in phages and plasmids. Here, the authors reveal the mechanism of the target nucleic acid preference of Type III-A CRISPR-Cas complexes at the transcription bubble by a combination of structural and biochemical approaches.Tina Y. LiuJun-Jie LiuAbhishek J. AdithamEva NogalesJennifer A. DoudnaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tina Y. Liu Jun-Jie Liu Abhishek J. Aditham Eva Nogales Jennifer A. Doudna Target preference of Type III-A CRISPR-Cas complexes at the transcription bubble
description	Type III CRISPR-Cas systems are able to target transcriptionally active DNA sequences in phages and plasmids. Here, the authors reveal the mechanism of the target nucleic acid preference of Type III-A CRISPR-Cas complexes at the transcription bubble by a combination of structural and biochemical approaches.
format	article
author	Tina Y. Liu Jun-Jie Liu Abhishek J. Aditham Eva Nogales Jennifer A. Doudna
author_facet	Tina Y. Liu Jun-Jie Liu Abhishek J. Aditham Eva Nogales Jennifer A. Doudna
author_sort	Tina Y. Liu
title	Target preference of Type III-A CRISPR-Cas complexes at the transcription bubble
title_short	Target preference of Type III-A CRISPR-Cas complexes at the transcription bubble
title_full	Target preference of Type III-A CRISPR-Cas complexes at the transcription bubble
title_fullStr	Target preference of Type III-A CRISPR-Cas complexes at the transcription bubble
title_full_unstemmed	Target preference of Type III-A CRISPR-Cas complexes at the transcription bubble
title_sort	target preference of type iii-a crispr-cas complexes at the transcription bubble
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/5a2efd0e054746c6934bd0d016c53fc2
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Target preference of Type III-A CRISPR-Cas complexes at the transcription bubble

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