Target preference of Type III-A CRISPR-Cas complexes at the transcription bubble

Type III CRISPR-Cas systems are able to target transcriptionally active DNA sequences in phages and plasmids. Here, the authors reveal the mechanism of the target nucleic acid preference of Type III-A CRISPR-Cas complexes at the transcription bubble by a combination of structural and biochemical app...

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Auteurs principaux: Tina Y. Liu, Jun-Jie Liu, Abhishek J. Aditham, Eva Nogales, Jennifer A. Doudna
Format: article
Langue:EN
Publié: Nature Portfolio 2019
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Accès en ligne:https://doaj.org/article/5a2efd0e054746c6934bd0d016c53fc2
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