Treatment of a flunixin meglumine overdose with intravenous administration of lipid emulsion and therapeutic plasma exchange in a Nigerian dwarf buck kid (Capra aegagrus hircus)

Abstract A 12 week‐old Nigerian dwarf (Capra aegagrus hircus) buck kid was hospitalized for management of obstructive urolithiasis. Postoperatively, he was inadvertently administered 16‐times greater than his calculated dose of a nonsteroidal anti‐inflammatory drug (NSAID; 17.5 mg/kg flunixin meglum...

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Autores principales:	Emmanuelle Marie Butty, Caroline Ann McKinney, Amanda Jane Prisk
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	flunixin meglumine goat intravenous lipid emulsion NSAID therapeutic plasma exchange toxicity Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/5a2fbce71a674e198a5d4eec4281aeb1
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spelling	oai:doaj.org-article:5a2fbce71a674e198a5d4eec4281aeb12021-11-30T17:01:05ZTreatment of a flunixin meglumine overdose with intravenous administration of lipid emulsion and therapeutic plasma exchange in a Nigerian dwarf buck kid (Capra aegagrus hircus)1939-16760891-664010.1111/jvim.16124https://doaj.org/article/5a2fbce71a674e198a5d4eec4281aeb12021-05-01T00:00:00Zhttps://doi.org/10.1111/jvim.16124https://doaj.org/toc/0891-6640https://doaj.org/toc/1939-1676Abstract A 12 week‐old Nigerian dwarf (Capra aegagrus hircus) buck kid was hospitalized for management of obstructive urolithiasis. Postoperatively, he was inadvertently administered 16‐times greater than his calculated dose of a nonsteroidal anti‐inflammatory drug (NSAID; 17.5 mg/kg flunixin meglumine, IV). The goat was treated with intravenous administration of lipid emulsion (ILE) prior to membrane‐based therapeutic plasma exchange (mTPE) under general anesthesia. The increased coagulability inherent to small ruminants in comparison with dogs and cats warranted specific adjustments in the prescription of anticoagulation, blood flow, and filtration fraction to avoid circuit clotting during mTPE. Serum flunixin meglumine concentration measured before, during, and after mTPE revealed marked reduction in drug concentration. After the combined treatments, no clinical evidence of NSAID gastrointestinal or renal toxicosis was detected. This case report describes successful management of flunixin meglumine overdose in a small ruminant using combined ILE and mTPE.Emmanuelle Marie ButtyCaroline Ann McKinneyAmanda Jane PriskWileyarticleflunixin megluminegoatintravenous lipid emulsionNSAIDtherapeutic plasma exchangetoxicityVeterinary medicineSF600-1100ENJournal of Veterinary Internal Medicine, Vol 35, Iss 3, Pp 1626-1630 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	flunixin meglumine goat intravenous lipid emulsion NSAID therapeutic plasma exchange toxicity Veterinary medicine SF600-1100
spellingShingle	flunixin meglumine goat intravenous lipid emulsion NSAID therapeutic plasma exchange toxicity Veterinary medicine SF600-1100 Emmanuelle Marie Butty Caroline Ann McKinney Amanda Jane Prisk Treatment of a flunixin meglumine overdose with intravenous administration of lipid emulsion and therapeutic plasma exchange in a Nigerian dwarf buck kid (Capra aegagrus hircus)
description	Abstract A 12 week‐old Nigerian dwarf (Capra aegagrus hircus) buck kid was hospitalized for management of obstructive urolithiasis. Postoperatively, he was inadvertently administered 16‐times greater than his calculated dose of a nonsteroidal anti‐inflammatory drug (NSAID; 17.5 mg/kg flunixin meglumine, IV). The goat was treated with intravenous administration of lipid emulsion (ILE) prior to membrane‐based therapeutic plasma exchange (mTPE) under general anesthesia. The increased coagulability inherent to small ruminants in comparison with dogs and cats warranted specific adjustments in the prescription of anticoagulation, blood flow, and filtration fraction to avoid circuit clotting during mTPE. Serum flunixin meglumine concentration measured before, during, and after mTPE revealed marked reduction in drug concentration. After the combined treatments, no clinical evidence of NSAID gastrointestinal or renal toxicosis was detected. This case report describes successful management of flunixin meglumine overdose in a small ruminant using combined ILE and mTPE.
format	article
author	Emmanuelle Marie Butty Caroline Ann McKinney Amanda Jane Prisk
author_facet	Emmanuelle Marie Butty Caroline Ann McKinney Amanda Jane Prisk
author_sort	Emmanuelle Marie Butty
title	Treatment of a flunixin meglumine overdose with intravenous administration of lipid emulsion and therapeutic plasma exchange in a Nigerian dwarf buck kid (Capra aegagrus hircus)
title_short	Treatment of a flunixin meglumine overdose with intravenous administration of lipid emulsion and therapeutic plasma exchange in a Nigerian dwarf buck kid (Capra aegagrus hircus)
title_full	Treatment of a flunixin meglumine overdose with intravenous administration of lipid emulsion and therapeutic plasma exchange in a Nigerian dwarf buck kid (Capra aegagrus hircus)
title_fullStr	Treatment of a flunixin meglumine overdose with intravenous administration of lipid emulsion and therapeutic plasma exchange in a Nigerian dwarf buck kid (Capra aegagrus hircus)
title_full_unstemmed	Treatment of a flunixin meglumine overdose with intravenous administration of lipid emulsion and therapeutic plasma exchange in a Nigerian dwarf buck kid (Capra aegagrus hircus)
title_sort	treatment of a flunixin meglumine overdose with intravenous administration of lipid emulsion and therapeutic plasma exchange in a nigerian dwarf buck kid (capra aegagrus hircus)
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/5a2fbce71a674e198a5d4eec4281aeb1
work_keys_str_mv	AT emmanuellemariebutty treatmentofaflunixinmeglumineoverdosewithintravenousadministrationoflipidemulsionandtherapeuticplasmaexchangeinanigeriandwarfbuckkidcapraaegagrushircus AT carolineannmckinney treatmentofaflunixinmeglumineoverdosewithintravenousadministrationoflipidemulsionandtherapeuticplasmaexchangeinanigeriandwarfbuckkidcapraaegagrushircus AT amandajaneprisk treatmentofaflunixinmeglumineoverdosewithintravenousadministrationoflipidemulsionandtherapeuticplasmaexchangeinanigeriandwarfbuckkidcapraaegagrushircus
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Treatment of a flunixin meglumine overdose with intravenous administration of lipid emulsion and therapeutic plasma exchange in a Nigerian dwarf buck kid (Capra aegagrus hircus)

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