Preventing microbial biofilms on catheter tubes using ultrasonic guided waves

Abstract Biofilms on indwelling tubes and medical prosthetic devices are among the leading causes of antibiotic-resistant bacterial infections. In this work, a new anti-biofilm catheter prototype was proposed. By combining an endotracheal tube (ET) with a group of ultrasonic guided wave (UGW) transd...

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Autores principales:	Huanlei Wang, Fengmeng Teng, Xin Yang, Xiasheng Guo, Juan Tu, Chunbing Zhang, Dong Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5a33a14c3c48456ca2d041f891d27da3
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spelling	oai:doaj.org-article:5a33a14c3c48456ca2d041f891d27da32021-12-02T16:06:01ZPreventing microbial biofilms on catheter tubes using ultrasonic guided waves10.1038/s41598-017-00705-82045-2322https://doaj.org/article/5a33a14c3c48456ca2d041f891d27da32017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00705-8https://doaj.org/toc/2045-2322Abstract Biofilms on indwelling tubes and medical prosthetic devices are among the leading causes of antibiotic-resistant bacterial infections. In this work, a new anti-biofilm catheter prototype was proposed. By combining an endotracheal tube (ET) with a group of ultrasonic guided wave (UGW) transducers, the general idea was to prevent bacteria aggregation with UGW vibrations. Based on quantitative analysis of UGW propagation, detailed approach was achieved through (a) selection of ultrasonic frequency, wave modes and vibration amplitude; and (b) adoption of wave coupling and 45° wave incidence technique. Performance of the proposed UGW-ET prototype was demonstrated via in vitro experiments, during which it deterred deposition of Pseudomonas aeruginosa (P. aeruginosa) biofilms successfully. With current configuration, UGW amplitudes ranged from 0.05–5 nm could be optimal to achieve biofilm prevention. This work sheds a light in the underlying mechanism of ultrasound-mediated biofilm prevention, and will inspire the development of new catheters of better antibacterial capability.Huanlei WangFengmeng TengXin YangXiasheng GuoJuan TuChunbing ZhangDong ZhangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Huanlei Wang Fengmeng Teng Xin Yang Xiasheng Guo Juan Tu Chunbing Zhang Dong Zhang Preventing microbial biofilms on catheter tubes using ultrasonic guided waves
description	Abstract Biofilms on indwelling tubes and medical prosthetic devices are among the leading causes of antibiotic-resistant bacterial infections. In this work, a new anti-biofilm catheter prototype was proposed. By combining an endotracheal tube (ET) with a group of ultrasonic guided wave (UGW) transducers, the general idea was to prevent bacteria aggregation with UGW vibrations. Based on quantitative analysis of UGW propagation, detailed approach was achieved through (a) selection of ultrasonic frequency, wave modes and vibration amplitude; and (b) adoption of wave coupling and 45° wave incidence technique. Performance of the proposed UGW-ET prototype was demonstrated via in vitro experiments, during which it deterred deposition of Pseudomonas aeruginosa (P. aeruginosa) biofilms successfully. With current configuration, UGW amplitudes ranged from 0.05–5 nm could be optimal to achieve biofilm prevention. This work sheds a light in the underlying mechanism of ultrasound-mediated biofilm prevention, and will inspire the development of new catheters of better antibacterial capability.
format	article
author	Huanlei Wang Fengmeng Teng Xin Yang Xiasheng Guo Juan Tu Chunbing Zhang Dong Zhang
author_facet	Huanlei Wang Fengmeng Teng Xin Yang Xiasheng Guo Juan Tu Chunbing Zhang Dong Zhang
author_sort	Huanlei Wang
title	Preventing microbial biofilms on catheter tubes using ultrasonic guided waves
title_short	Preventing microbial biofilms on catheter tubes using ultrasonic guided waves
title_full	Preventing microbial biofilms on catheter tubes using ultrasonic guided waves
title_fullStr	Preventing microbial biofilms on catheter tubes using ultrasonic guided waves
title_full_unstemmed	Preventing microbial biofilms on catheter tubes using ultrasonic guided waves
title_sort	preventing microbial biofilms on catheter tubes using ultrasonic guided waves
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/5a33a14c3c48456ca2d041f891d27da3
work_keys_str_mv	AT huanleiwang preventingmicrobialbiofilmsoncathetertubesusingultrasonicguidedwaves AT fengmengteng preventingmicrobialbiofilmsoncathetertubesusingultrasonicguidedwaves AT xinyang preventingmicrobialbiofilmsoncathetertubesusingultrasonicguidedwaves AT xiashengguo preventingmicrobialbiofilmsoncathetertubesusingultrasonicguidedwaves AT juantu preventingmicrobialbiofilmsoncathetertubesusingultrasonicguidedwaves AT chunbingzhang preventingmicrobialbiofilmsoncathetertubesusingultrasonicguidedwaves AT dongzhang preventingmicrobialbiofilmsoncathetertubesusingultrasonicguidedwaves
_version_	1718385150507614208

Preventing microbial biofilms on catheter tubes using ultrasonic guided waves

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