A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids

A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids

Abnormal blood lipid levels are important risk factors for cardiovascular and other various diseases. Here the authors conduct a large-scale multi-ethnic epigenome-wide association study combined with epigenetic (cis-QTL and eQTM) data, and identify CpG-lipid traits associations that are specific to...

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Autores principales: Mina-A Jhun, Michael Mendelson, Rory Wilson, Rahul Gondalia, Roby Joehanes, Elias Salfati, Xiaoping Zhao, Kim Valeska Emilie Braun, Anh Nguyet Do, Åsa K. Hedman, Tao Zhang, Elena Carnero-Montoro, Jincheng Shen, Traci M. Bartz, Jennifer A. Brody, May E. Montasser, Jeff R. O’Connell, Chen Yao, Rui Xia, Eric Boerwinkle, Megan Grove, Weihua Guan, Pfeiffer Liliane, Paula Singmann, Martina Müller-Nurasyid, Thomas Meitinger, Christian Gieger, Annette Peters, Wei Zhao, Erin B. Ware, Jennifer A. Smith, Klodian Dhana, Joyce van Meurs, Andre Uitterlinden, Mohammad Arfan Ikram, Mohsen Ghanbari, Deugi Zhi, Stefan Gustafsson, Lars Lind, Shengxu Li, Dianjianyi Sun, Tim D. Spector, Yii-der Ida Chen, Coleen Damcott, Alan R. Shuldiner, Devin M. Absher, Steve Horvath, Philip S. Tsao, Sharon Kardia, Bruce M. Psaty, Nona Sotoodehnia, Jordana T. Bell, Erik Ingelsson, Wei Chen, Abbas Dehghan, Donna K. Arnett, Melanie Waldenberger, Lifang Hou, Eric A. Whitsel, Andrea Baccarelli, Daniel Levy, Myriam Fornage, Marguerite R. Irvin, Themistocles L. Assimes
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Publicado: Nature Portfolio 2021
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spelling oai:doaj.org-article:5a34ff34ea7042f0b1ef2141f1a26dde2021-12-02T14:34:12ZA multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids10.1038/s41467-021-23899-y2041-1723https://doaj.org/article/5a34ff34ea7042f0b1ef2141f1a26dde2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23899-yhttps://doaj.org/toc/2041-1723Abnormal blood lipid levels are important risk factors for cardiovascular and other various diseases. Here the authors conduct a large-scale multi-ethnic epigenome-wide association study combined with epigenetic (cis-QTL and eQTM) data, and identify CpG-lipid traits associations that are specific to or common across racial/ethnic groups.Mina-A JhunMichael MendelsonRory WilsonRahul GondaliaRoby JoehanesElias SalfatiXiaoping ZhaoKim Valeska Emilie BraunAnh Nguyet DoÅsa K. HedmanTao ZhangElena Carnero-MontoroJincheng ShenTraci M. BartzJennifer A. BrodyMay E. MontasserJeff R. O’ConnellChen YaoRui XiaEric BoerwinkleMegan GroveWeihua GuanPfeiffer LilianePaula SingmannMartina Müller-NurasyidThomas MeitingerChristian GiegerAnnette PetersWei ZhaoErin B. WareJennifer A. SmithKlodian DhanaJoyce van MeursAndre UitterlindenMohammad Arfan IkramMohsen GhanbariDeugi ZhiStefan GustafssonLars LindShengxu LiDianjianyi SunTim D. SpectorYii-der Ida ChenColeen DamcottAlan R. ShuldinerDevin M. AbsherSteve HorvathPhilip S. TsaoSharon KardiaBruce M. PsatyNona SotoodehniaJordana T. BellErik IngelssonWei ChenAbbas DehghanDonna K. ArnettMelanie WaldenbergerLifang HouEric A. WhitselAndrea BaccarelliDaniel LevyMyriam FornageMarguerite R. IrvinThemistocles L. AssimesNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Mina-A Jhun
Michael Mendelson
Rory Wilson
Rahul Gondalia
Roby Joehanes
Elias Salfati
Xiaoping Zhao
Kim Valeska Emilie Braun
Anh Nguyet Do
Åsa K. Hedman
Tao Zhang
Elena Carnero-Montoro
Jincheng Shen
Traci M. Bartz
Jennifer A. Brody
May E. Montasser
Jeff R. O’Connell
Chen Yao
Rui Xia
Eric Boerwinkle
Megan Grove
Weihua Guan
Pfeiffer Liliane
Paula Singmann
Martina Müller-Nurasyid
Thomas Meitinger
Christian Gieger
Annette Peters
Wei Zhao
Erin B. Ware
Jennifer A. Smith
Klodian Dhana
Joyce van Meurs
Andre Uitterlinden
Mohammad Arfan Ikram
Mohsen Ghanbari
Deugi Zhi
Stefan Gustafsson
Lars Lind
Shengxu Li
Dianjianyi Sun
Tim D. Spector
Yii-der Ida Chen
Coleen Damcott
Alan R. Shuldiner
Devin M. Absher
Steve Horvath
Philip S. Tsao
Sharon Kardia
Bruce M. Psaty
Nona Sotoodehnia
Jordana T. Bell
Erik Ingelsson
Wei Chen
Abbas Dehghan
Donna K. Arnett
Melanie Waldenberger
Lifang Hou
Eric A. Whitsel
Andrea Baccarelli
Daniel Levy
Myriam Fornage
Marguerite R. Irvin
Themistocles L. Assimes
A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids
description Abnormal blood lipid levels are important risk factors for cardiovascular and other various diseases. Here the authors conduct a large-scale multi-ethnic epigenome-wide association study combined with epigenetic (cis-QTL and eQTM) data, and identify CpG-lipid traits associations that are specific to or common across racial/ethnic groups.
format article
author Mina-A Jhun
Michael Mendelson
Rory Wilson
Rahul Gondalia
Roby Joehanes
Elias Salfati
Xiaoping Zhao
Kim Valeska Emilie Braun
Anh Nguyet Do
Åsa K. Hedman
Tao Zhang
Elena Carnero-Montoro
Jincheng Shen
Traci M. Bartz
Jennifer A. Brody
May E. Montasser
Jeff R. O’Connell
Chen Yao
Rui Xia
Eric Boerwinkle
Megan Grove
Weihua Guan
Pfeiffer Liliane
Paula Singmann
Martina Müller-Nurasyid
Thomas Meitinger
Christian Gieger
Annette Peters
Wei Zhao
Erin B. Ware
Jennifer A. Smith
Klodian Dhana
Joyce van Meurs
Andre Uitterlinden
Mohammad Arfan Ikram
Mohsen Ghanbari
Deugi Zhi
Stefan Gustafsson
Lars Lind
Shengxu Li
Dianjianyi Sun
Tim D. Spector
Yii-der Ida Chen
Coleen Damcott
Alan R. Shuldiner
Devin M. Absher
Steve Horvath
Philip S. Tsao
Sharon Kardia
Bruce M. Psaty
Nona Sotoodehnia
Jordana T. Bell
Erik Ingelsson
Wei Chen
Abbas Dehghan
Donna K. Arnett
Melanie Waldenberger
Lifang Hou
Eric A. Whitsel
Andrea Baccarelli
Daniel Levy
Myriam Fornage
Marguerite R. Irvin
Themistocles L. Assimes
author_facet Mina-A Jhun
Michael Mendelson
Rory Wilson
Rahul Gondalia
Roby Joehanes
Elias Salfati
Xiaoping Zhao
Kim Valeska Emilie Braun
Anh Nguyet Do
Åsa K. Hedman
Tao Zhang
Elena Carnero-Montoro
Jincheng Shen
Traci M. Bartz
Jennifer A. Brody
May E. Montasser
Jeff R. O’Connell
Chen Yao
Rui Xia
Eric Boerwinkle
Megan Grove
Weihua Guan
Pfeiffer Liliane
Paula Singmann
Martina Müller-Nurasyid
Thomas Meitinger
Christian Gieger
Annette Peters
Wei Zhao
Erin B. Ware
Jennifer A. Smith
Klodian Dhana
Joyce van Meurs
Andre Uitterlinden
Mohammad Arfan Ikram
Mohsen Ghanbari
Deugi Zhi
Stefan Gustafsson
Lars Lind
Shengxu Li
Dianjianyi Sun
Tim D. Spector
Yii-der Ida Chen
Coleen Damcott
Alan R. Shuldiner
Devin M. Absher
Steve Horvath
Philip S. Tsao
Sharon Kardia
Bruce M. Psaty
Nona Sotoodehnia
Jordana T. Bell
Erik Ingelsson
Wei Chen
Abbas Dehghan
Donna K. Arnett
Melanie Waldenberger
Lifang Hou
Eric A. Whitsel
Andrea Baccarelli
Daniel Levy
Myriam Fornage
Marguerite R. Irvin
Themistocles L. Assimes
author_sort Mina-A Jhun
title A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids
title_short A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids
title_full A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids
title_fullStr A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids
title_full_unstemmed A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids
title_sort multi-ethnic epigenome-wide association study of leukocyte dna methylation and blood lipids
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/5a34ff34ea7042f0b1ef2141f1a26dde
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