Candidalysin activates innate epithelial immune responses via epidermal growth factor receptor

Candida albicans is an opportunistic fungus primarily affecting immunocompromised patients. Here, the authors identify a novel mechanism of host immune stimulation and highlight candidalysin and EGFR signalling components as potential targets for prophylactic and therapeutic intervention of mucosal...

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Autores principales:	Jemima Ho, Xuexin Yang, Spyridoula-Angeliki Nikou, Nessim Kichik, Andrew Donkin, Nicole O. Ponde, Jonathan P. Richardson, Remi L. Gratacap, Linda S. Archambault, Christian P. Zwirner, Celia Murciano, Rhonda Henley-Smith, Selvam Thavaraj, Christopher J. Tynan, Sarah L. Gaffen, Bernhard Hube, Robert T. Wheeler, David L. Moyes, Julian R. Naglik
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5a35ef4f63da4f5da3fd3d4b2fc4fa96
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spelling	oai:doaj.org-article:5a35ef4f63da4f5da3fd3d4b2fc4fa962021-12-02T15:35:39ZCandidalysin activates innate epithelial immune responses via epidermal growth factor receptor10.1038/s41467-019-09915-22041-1723https://doaj.org/article/5a35ef4f63da4f5da3fd3d4b2fc4fa962019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09915-2https://doaj.org/toc/2041-1723Candida albicans is an opportunistic fungus primarily affecting immunocompromised patients. Here, the authors identify a novel mechanism of host immune stimulation and highlight candidalysin and EGFR signalling components as potential targets for prophylactic and therapeutic intervention of mucosal candidiasis.Jemima HoXuexin YangSpyridoula-Angeliki NikouNessim KichikAndrew DonkinNicole O. PondeJonathan P. RichardsonRemi L. GratacapLinda S. ArchambaultChristian P. ZwirnerCelia MurcianoRhonda Henley-SmithSelvam ThavarajChristopher J. TynanSarah L. GaffenBernhard HubeRobert T. WheelerDavid L. MoyesJulian R. NaglikNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jemima Ho Xuexin Yang Spyridoula-Angeliki Nikou Nessim Kichik Andrew Donkin Nicole O. Ponde Jonathan P. Richardson Remi L. Gratacap Linda S. Archambault Christian P. Zwirner Celia Murciano Rhonda Henley-Smith Selvam Thavaraj Christopher J. Tynan Sarah L. Gaffen Bernhard Hube Robert T. Wheeler David L. Moyes Julian R. Naglik Candidalysin activates innate epithelial immune responses via epidermal growth factor receptor
description	Candida albicans is an opportunistic fungus primarily affecting immunocompromised patients. Here, the authors identify a novel mechanism of host immune stimulation and highlight candidalysin and EGFR signalling components as potential targets for prophylactic and therapeutic intervention of mucosal candidiasis.
format	article
author	Jemima Ho Xuexin Yang Spyridoula-Angeliki Nikou Nessim Kichik Andrew Donkin Nicole O. Ponde Jonathan P. Richardson Remi L. Gratacap Linda S. Archambault Christian P. Zwirner Celia Murciano Rhonda Henley-Smith Selvam Thavaraj Christopher J. Tynan Sarah L. Gaffen Bernhard Hube Robert T. Wheeler David L. Moyes Julian R. Naglik
author_facet	Jemima Ho Xuexin Yang Spyridoula-Angeliki Nikou Nessim Kichik Andrew Donkin Nicole O. Ponde Jonathan P. Richardson Remi L. Gratacap Linda S. Archambault Christian P. Zwirner Celia Murciano Rhonda Henley-Smith Selvam Thavaraj Christopher J. Tynan Sarah L. Gaffen Bernhard Hube Robert T. Wheeler David L. Moyes Julian R. Naglik
author_sort	Jemima Ho
title	Candidalysin activates innate epithelial immune responses via epidermal growth factor receptor
title_short	Candidalysin activates innate epithelial immune responses via epidermal growth factor receptor
title_full	Candidalysin activates innate epithelial immune responses via epidermal growth factor receptor
title_fullStr	Candidalysin activates innate epithelial immune responses via epidermal growth factor receptor
title_full_unstemmed	Candidalysin activates innate epithelial immune responses via epidermal growth factor receptor
title_sort	candidalysin activates innate epithelial immune responses via epidermal growth factor receptor
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/5a35ef4f63da4f5da3fd3d4b2fc4fa96
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Candidalysin activates innate epithelial immune responses via epidermal growth factor receptor

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