Camel milk ameliorates inflammatory mechanisms in an alcohol-induced liver injury mouse model

Abstract Camel milk (CM) is considered to protect the liver in the practice of traditional medicine in nomadic areas. The purpose of the present study was to investigate the effects of CM on the hepatic biochemical and multiple omics alterations induced by chronic alcoholic liver disease (ALD). An i...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Liang Ming, Bule Qi, Shiqi Hao, Rimutu Ji
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5a3705d29092467d8b0cc418d4faed1b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5a3705d29092467d8b0cc418d4faed1b
record_format	dspace
spelling	oai:doaj.org-article:5a3705d29092467d8b0cc418d4faed1b2021-11-28T12:18:32ZCamel milk ameliorates inflammatory mechanisms in an alcohol-induced liver injury mouse model10.1038/s41598-021-02357-12045-2322https://doaj.org/article/5a3705d29092467d8b0cc418d4faed1b2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02357-1https://doaj.org/toc/2045-2322Abstract Camel milk (CM) is considered to protect the liver in the practice of traditional medicine in nomadic areas. The purpose of the present study was to investigate the effects of CM on the hepatic biochemical and multiple omics alterations induced by chronic alcoholic liver disease (ALD). An intragastric gavage mice Lieber DeCarli + Gao binge model (NIAAA model) was employed to investigate the inflammatory mechanism of camel milk on the liver tissue of mice. A gut microbiota of the feces of mice and transcriptomic and proteomic analyses of the liver of mice were performed. Analysis of serum and liver biochemical indexes revealed that camel milk not only prevents alcohol-induced colonic dysfunction and lipid accumulation, but also regulates oxidative stress and inflammatory cytokine production to protect against chronic ALD in mouse. The gut microbial community of mice treated with camel milk was more similar to the untreated control group than to the model group, indicating that the intake of camel milk pre- and post-alcohol gavage effectively prevents and alleviates the intestinal microbial disorder caused by chronic alcoholism in mice. Furthermore, the results of the transcriptomic and proteomic analyses of the liver tissue showed that camel milk can improve alcoholic liver injury in mice by regulating inflammatory factors and immune system disruptions. This study provides insights into the molecular mechanism by which camel milk can be developed as a potential functional food with no side effects and against liver injury.Liang MingBule QiShiqi HaoRimutu JiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Liang Ming Bule Qi Shiqi Hao Rimutu Ji Camel milk ameliorates inflammatory mechanisms in an alcohol-induced liver injury mouse model
description	Abstract Camel milk (CM) is considered to protect the liver in the practice of traditional medicine in nomadic areas. The purpose of the present study was to investigate the effects of CM on the hepatic biochemical and multiple omics alterations induced by chronic alcoholic liver disease (ALD). An intragastric gavage mice Lieber DeCarli + Gao binge model (NIAAA model) was employed to investigate the inflammatory mechanism of camel milk on the liver tissue of mice. A gut microbiota of the feces of mice and transcriptomic and proteomic analyses of the liver of mice were performed. Analysis of serum and liver biochemical indexes revealed that camel milk not only prevents alcohol-induced colonic dysfunction and lipid accumulation, but also regulates oxidative stress and inflammatory cytokine production to protect against chronic ALD in mouse. The gut microbial community of mice treated with camel milk was more similar to the untreated control group than to the model group, indicating that the intake of camel milk pre- and post-alcohol gavage effectively prevents and alleviates the intestinal microbial disorder caused by chronic alcoholism in mice. Furthermore, the results of the transcriptomic and proteomic analyses of the liver tissue showed that camel milk can improve alcoholic liver injury in mice by regulating inflammatory factors and immune system disruptions. This study provides insights into the molecular mechanism by which camel milk can be developed as a potential functional food with no side effects and against liver injury.
format	article
author	Liang Ming Bule Qi Shiqi Hao Rimutu Ji
author_facet	Liang Ming Bule Qi Shiqi Hao Rimutu Ji
author_sort	Liang Ming
title	Camel milk ameliorates inflammatory mechanisms in an alcohol-induced liver injury mouse model
title_short	Camel milk ameliorates inflammatory mechanisms in an alcohol-induced liver injury mouse model
title_full	Camel milk ameliorates inflammatory mechanisms in an alcohol-induced liver injury mouse model
title_fullStr	Camel milk ameliorates inflammatory mechanisms in an alcohol-induced liver injury mouse model
title_full_unstemmed	Camel milk ameliorates inflammatory mechanisms in an alcohol-induced liver injury mouse model
title_sort	camel milk ameliorates inflammatory mechanisms in an alcohol-induced liver injury mouse model
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5a3705d29092467d8b0cc418d4faed1b
work_keys_str_mv	AT liangming camelmilkamelioratesinflammatorymechanismsinanalcoholinducedliverinjurymousemodel AT buleqi camelmilkamelioratesinflammatorymechanismsinanalcoholinducedliverinjurymousemodel AT shiqihao camelmilkamelioratesinflammatorymechanismsinanalcoholinducedliverinjurymousemodel AT rimutuji camelmilkamelioratesinflammatorymechanismsinanalcoholinducedliverinjurymousemodel
_version_	1718408078495318016

Camel milk ameliorates inflammatory mechanisms in an alcohol-induced liver injury mouse model

Ejemplares similares