Newly Diagnosed IDH-Wildtype Glioblastoma and Temporal Muscle Thickness: A Multicenter Analysis

Background: Reduced temporal muscle thickness (TMT) has been discussed as a prognostic marker in IDH-wildtype glioblastoma. This retrospective multicenter study was designed to investigate whether TMT is an independent prognostic marker in newly diagnosed glioblastoma. Methods: TMT was retrospective...

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Autores principales:	Tim Wende, Johannes Kasper, Gordian Prasse, Änne Glass, Thomas Kriesen, Thomas M. Freiman, Jürgen Meixensberger, Christian Henker
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	glioblastoma temporal muscle thickness survival prognostic marker Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/5a379d50e8a448e1925c6e300f23406f
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spelling	oai:doaj.org-article:5a379d50e8a448e1925c6e300f23406f2021-11-25T17:01:33ZNewly Diagnosed IDH-Wildtype Glioblastoma and Temporal Muscle Thickness: A Multicenter Analysis10.3390/cancers132256102072-6694https://doaj.org/article/5a379d50e8a448e1925c6e300f23406f2021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/22/5610https://doaj.org/toc/2072-6694Background: Reduced temporal muscle thickness (TMT) has been discussed as a prognostic marker in IDH-wildtype glioblastoma. This retrospective multicenter study was designed to investigate whether TMT is an independent prognostic marker in newly diagnosed glioblastoma. Methods: TMT was retrospectively measured in 335 patients with newly diagnosed glioblastoma between 1 January 2014 and 31 December 2019 at the University Hospitals of Leipzig and Rostock. The cohort was dichotomized by TMT and tested for association with overall survival (OS) after 12 months by multivariate proportional hazard calculation. Results: TMT of 7.0 mm or more was associated with increased OS (46.3 ± 3.9% versus 36.6 ± 3.9%, <i>p</i> > 0.001). However, the sub-groups showed significant epidemiological differences. In multivariate proportional hazard calculation, patient age (HR 1.01; <i>p</i> = 0.004), MGMT promoter status (HR 0.76; <i>p</i> = 0.002), EOR (HR 0.61), adjuvant irradiation (HR 0.24) and adjuvant chemotherapy (HR 0.40; all <i>p</i> < 0.001) were independent prognostic markers for OS. However, KPS (HR 1.00, <i>p</i> = 0.31), BMI (HR 0.98, <i>p</i> = 0.11) and TMT (HR 1.06; <i>p</i> = 0.07) were not significantly associated with OS. Conclusion: TMT has not appeared as a statistically independent prognostic marker in this cohort of patients with newly diagnosed IDH-wildtype glioblastoma.Tim WendeJohannes KasperGordian PrasseÄnne GlassThomas KriesenThomas M. FreimanJürgen MeixensbergerChristian HenkerMDPI AGarticleglioblastomatemporal muscle thicknesssurvivalprognostic markerNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5610, p 5610 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	glioblastoma temporal muscle thickness survival prognostic marker Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	glioblastoma temporal muscle thickness survival prognostic marker Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Tim Wende Johannes Kasper Gordian Prasse Änne Glass Thomas Kriesen Thomas M. Freiman Jürgen Meixensberger Christian Henker Newly Diagnosed IDH-Wildtype Glioblastoma and Temporal Muscle Thickness: A Multicenter Analysis
description	Background: Reduced temporal muscle thickness (TMT) has been discussed as a prognostic marker in IDH-wildtype glioblastoma. This retrospective multicenter study was designed to investigate whether TMT is an independent prognostic marker in newly diagnosed glioblastoma. Methods: TMT was retrospectively measured in 335 patients with newly diagnosed glioblastoma between 1 January 2014 and 31 December 2019 at the University Hospitals of Leipzig and Rostock. The cohort was dichotomized by TMT and tested for association with overall survival (OS) after 12 months by multivariate proportional hazard calculation. Results: TMT of 7.0 mm or more was associated with increased OS (46.3 ± 3.9% versus 36.6 ± 3.9%, <i>p</i> > 0.001). However, the sub-groups showed significant epidemiological differences. In multivariate proportional hazard calculation, patient age (HR 1.01; <i>p</i> = 0.004), MGMT promoter status (HR 0.76; <i>p</i> = 0.002), EOR (HR 0.61), adjuvant irradiation (HR 0.24) and adjuvant chemotherapy (HR 0.40; all <i>p</i> < 0.001) were independent prognostic markers for OS. However, KPS (HR 1.00, <i>p</i> = 0.31), BMI (HR 0.98, <i>p</i> = 0.11) and TMT (HR 1.06; <i>p</i> = 0.07) were not significantly associated with OS. Conclusion: TMT has not appeared as a statistically independent prognostic marker in this cohort of patients with newly diagnosed IDH-wildtype glioblastoma.
format	article
author	Tim Wende Johannes Kasper Gordian Prasse Änne Glass Thomas Kriesen Thomas M. Freiman Jürgen Meixensberger Christian Henker
author_facet	Tim Wende Johannes Kasper Gordian Prasse Änne Glass Thomas Kriesen Thomas M. Freiman Jürgen Meixensberger Christian Henker
author_sort	Tim Wende
title	Newly Diagnosed IDH-Wildtype Glioblastoma and Temporal Muscle Thickness: A Multicenter Analysis
title_short	Newly Diagnosed IDH-Wildtype Glioblastoma and Temporal Muscle Thickness: A Multicenter Analysis
title_full	Newly Diagnosed IDH-Wildtype Glioblastoma and Temporal Muscle Thickness: A Multicenter Analysis
title_fullStr	Newly Diagnosed IDH-Wildtype Glioblastoma and Temporal Muscle Thickness: A Multicenter Analysis
title_full_unstemmed	Newly Diagnosed IDH-Wildtype Glioblastoma and Temporal Muscle Thickness: A Multicenter Analysis
title_sort	newly diagnosed idh-wildtype glioblastoma and temporal muscle thickness: a multicenter analysis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/5a379d50e8a448e1925c6e300f23406f
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Newly Diagnosed IDH-Wildtype Glioblastoma and Temporal Muscle Thickness: A Multicenter Analysis

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