High aspartate aminotransferase to alanine aminotransferase ratio on admission as risk factor for poor prognosis in COVID-19 patients

Abstract This study aimed to analyze aspartate aminotransferase (AST) to alanine aminotransferase (ALT) ratio in COVID-19 patients. After exclusion, 567 inpatients were included in this study and separated into two groups according to their AST/ALT ratio on admission. Death was regarded as poor prog...

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Autores principales:	Cheng Qin, Yingxin Wei, Xiaoyu Lyu, Bangbo Zhao, Yunlu Feng, Tianhao Li, Hongtao Cao, Xiaoying Yang, Xingtong Zhou, Weibin Wang, Lei You, Yujun Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5a3d2e8c52ae4c039f8b9c71feb77fd7
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spelling	oai:doaj.org-article:5a3d2e8c52ae4c039f8b9c71feb77fd72021-12-02T18:37:06ZHigh aspartate aminotransferase to alanine aminotransferase ratio on admission as risk factor for poor prognosis in COVID-19 patients10.1038/s41598-020-73575-22045-2322https://doaj.org/article/5a3d2e8c52ae4c039f8b9c71feb77fd72020-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-73575-2https://doaj.org/toc/2045-2322Abstract This study aimed to analyze aspartate aminotransferase (AST) to alanine aminotransferase (ALT) ratio in COVID-19 patients. After exclusion, 567 inpatients were included in this study and separated into two groups according to their AST/ALT ratio on admission. Death was regarded as poor prognosis in this study. Of 567 patients, 200 (35.3%) had AST/ALT ≥ 1.38. Of the 200 patients, older age (median age 60 years), myalgia (64 [32%] cases), fatigue (91 [45.5%] cases), some comorbidities and outcomes were significantly different from patients with AST/ALT < 1.38. They also had worse chest computed tomography (CT) findings, laboratory results and severity scores. Levels of platelet count (OR 0.995, 95% CI [0.992–0.998]) and hemoglobin (OR 0.984, 95% CI [0.972–0.995]) were independently associated with AST/ALT ≥ 1.38 on admission. Furthermore, a high AST/ALT ratio on admission was an independent risk factor for poor prognosis (OR 99.9, 95% CI [2.1–4280.5]). In subsequent monitoring, both survivors and non-survivors showed decreased AST/ALT ratio during hospitalization. In conclusion, high AST/ALT ratio might be the indication of worse status and outcomes in COVID-19 patients.Cheng QinYingxin WeiXiaoyu LyuBangbo ZhaoYunlu FengTianhao LiHongtao CaoXiaoying YangXingtong ZhouWeibin WangLei YouYujun WangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Cheng Qin Yingxin Wei Xiaoyu Lyu Bangbo Zhao Yunlu Feng Tianhao Li Hongtao Cao Xiaoying Yang Xingtong Zhou Weibin Wang Lei You Yujun Wang High aspartate aminotransferase to alanine aminotransferase ratio on admission as risk factor for poor prognosis in COVID-19 patients
description	Abstract This study aimed to analyze aspartate aminotransferase (AST) to alanine aminotransferase (ALT) ratio in COVID-19 patients. After exclusion, 567 inpatients were included in this study and separated into two groups according to their AST/ALT ratio on admission. Death was regarded as poor prognosis in this study. Of 567 patients, 200 (35.3%) had AST/ALT ≥ 1.38. Of the 200 patients, older age (median age 60 years), myalgia (64 [32%] cases), fatigue (91 [45.5%] cases), some comorbidities and outcomes were significantly different from patients with AST/ALT < 1.38. They also had worse chest computed tomography (CT) findings, laboratory results and severity scores. Levels of platelet count (OR 0.995, 95% CI [0.992–0.998]) and hemoglobin (OR 0.984, 95% CI [0.972–0.995]) were independently associated with AST/ALT ≥ 1.38 on admission. Furthermore, a high AST/ALT ratio on admission was an independent risk factor for poor prognosis (OR 99.9, 95% CI [2.1–4280.5]). In subsequent monitoring, both survivors and non-survivors showed decreased AST/ALT ratio during hospitalization. In conclusion, high AST/ALT ratio might be the indication of worse status and outcomes in COVID-19 patients.
format	article
author	Cheng Qin Yingxin Wei Xiaoyu Lyu Bangbo Zhao Yunlu Feng Tianhao Li Hongtao Cao Xiaoying Yang Xingtong Zhou Weibin Wang Lei You Yujun Wang
author_facet	Cheng Qin Yingxin Wei Xiaoyu Lyu Bangbo Zhao Yunlu Feng Tianhao Li Hongtao Cao Xiaoying Yang Xingtong Zhou Weibin Wang Lei You Yujun Wang
author_sort	Cheng Qin
title	High aspartate aminotransferase to alanine aminotransferase ratio on admission as risk factor for poor prognosis in COVID-19 patients
title_short	High aspartate aminotransferase to alanine aminotransferase ratio on admission as risk factor for poor prognosis in COVID-19 patients
title_full	High aspartate aminotransferase to alanine aminotransferase ratio on admission as risk factor for poor prognosis in COVID-19 patients
title_fullStr	High aspartate aminotransferase to alanine aminotransferase ratio on admission as risk factor for poor prognosis in COVID-19 patients
title_full_unstemmed	High aspartate aminotransferase to alanine aminotransferase ratio on admission as risk factor for poor prognosis in COVID-19 patients
title_sort	high aspartate aminotransferase to alanine aminotransferase ratio on admission as risk factor for poor prognosis in covid-19 patients
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/5a3d2e8c52ae4c039f8b9c71feb77fd7
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High aspartate aminotransferase to alanine aminotransferase ratio on admission as risk factor for poor prognosis in COVID-19 patients

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