Influence of carbon nanotube length on toxicity to zebrafish embryos

Jinping Cheng,1,2 Shuk Han Cheng11Department of Biology and Chemistry, City University of Hong Kong, Hong Kong; 2State Key Laboratory of Estuarine and Coastal Research, East China Normal University, Shanghai, ChinaAbstract: There is currently a large difference of opinion in nanotoxicology studies o...

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Autores principales:	Cheng J, Cheng SH
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/5a3d52c39d46436ab03924c3fd49457c
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spelling	oai:doaj.org-article:5a3d52c39d46436ab03924c3fd49457c2021-12-02T03:00:40ZInfluence of carbon nanotube length on toxicity to zebrafish embryos1176-91141178-2013https://doaj.org/article/5a3d52c39d46436ab03924c3fd49457c2012-07-01T00:00:00Zhttp://www.dovepress.com/influence-of-carbon-nanotube-length-on-toxicity-to-zebrafish-embryos-a10473https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Jinping Cheng,1,2 Shuk Han Cheng11Department of Biology and Chemistry, City University of Hong Kong, Hong Kong; 2State Key Laboratory of Estuarine and Coastal Research, East China Normal University, Shanghai, ChinaAbstract: There is currently a large difference of opinion in nanotoxicology studies of nanomaterials. There is concern about why some studies have indicated that there is strong toxicity, while others have not. In this study, the length of carbon nanotubes greatly affected their toxicity in zebrafish embryos. Multiwalled carbon nanotubes (MWCNTs) were sonicated in a nitric acid solution for 24 hours and 48 hours. The modified MWCNTs were tested in early developing zebrafish embryo. MWCNTs prepared with the longer sonication time resulted in severe developmental toxicity; however, the shorter sonication time did not induce any obvious toxicity in the tested developing zebrafish embryos. The cellular and molecular changes of the affected zebrafish embryos were studied and the observed phenotypes scored. This study suggests that length plays an important role in the in vivo toxicity of functionalized CNTs. This study will help in furthering the understanding on current differences in toxicity studies of nanomaterials.Keywords: length, carbon nanotubes, sonication, developmental toxicity, zebrafishCheng JCheng SHDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2012, Iss default, Pp 3731-3739 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Cheng J Cheng SH Influence of carbon nanotube length on toxicity to zebrafish embryos
description	Jinping Cheng,1,2 Shuk Han Cheng11Department of Biology and Chemistry, City University of Hong Kong, Hong Kong; 2State Key Laboratory of Estuarine and Coastal Research, East China Normal University, Shanghai, ChinaAbstract: There is currently a large difference of opinion in nanotoxicology studies of nanomaterials. There is concern about why some studies have indicated that there is strong toxicity, while others have not. In this study, the length of carbon nanotubes greatly affected their toxicity in zebrafish embryos. Multiwalled carbon nanotubes (MWCNTs) were sonicated in a nitric acid solution for 24 hours and 48 hours. The modified MWCNTs were tested in early developing zebrafish embryo. MWCNTs prepared with the longer sonication time resulted in severe developmental toxicity; however, the shorter sonication time did not induce any obvious toxicity in the tested developing zebrafish embryos. The cellular and molecular changes of the affected zebrafish embryos were studied and the observed phenotypes scored. This study suggests that length plays an important role in the in vivo toxicity of functionalized CNTs. This study will help in furthering the understanding on current differences in toxicity studies of nanomaterials.Keywords: length, carbon nanotubes, sonication, developmental toxicity, zebrafish
format	article
author	Cheng J Cheng SH
author_facet	Cheng J Cheng SH
author_sort	Cheng J
title	Influence of carbon nanotube length on toxicity to zebrafish embryos
title_short	Influence of carbon nanotube length on toxicity to zebrafish embryos
title_full	Influence of carbon nanotube length on toxicity to zebrafish embryos
title_fullStr	Influence of carbon nanotube length on toxicity to zebrafish embryos
title_full_unstemmed	Influence of carbon nanotube length on toxicity to zebrafish embryos
title_sort	influence of carbon nanotube length on toxicity to zebrafish embryos
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/5a3d52c39d46436ab03924c3fd49457c
work_keys_str_mv	AT chengj influenceofcarbonnanotubelengthontoxicitytozebrafishembryos AT chengsh influenceofcarbonnanotubelengthontoxicitytozebrafishembryos
_version_	1718401986031779840

Influence of carbon nanotube length on toxicity to zebrafish embryos

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