Mutant ASXL1 induces age-related expansion of phenotypic hematopoietic stem cells through activation of Akt/mTOR pathway
ASXL1 mutations are frequently found in age-related clonal haemaotopoiesis (CH), but how they drive CH is unclear. Here the authors show that expression of C-terminal truncated ASXL1 in haematopoietic stem cells (HSCs) leads to Akt de-ubiquitination, activated Akt/mTOR signaling, and aberrant HSC pr...
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Nature Portfolio
2021
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oai:doaj.org-article:5a4339b6caee4c1d9bbb984e54dddbf02021-12-02T13:24:22ZMutant ASXL1 induces age-related expansion of phenotypic hematopoietic stem cells through activation of Akt/mTOR pathway10.1038/s41467-021-22053-y2041-1723https://doaj.org/article/5a4339b6caee4c1d9bbb984e54dddbf02021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22053-yhttps://doaj.org/toc/2041-1723ASXL1 mutations are frequently found in age-related clonal haemaotopoiesis (CH), but how they drive CH is unclear. Here the authors show that expression of C-terminal truncated ASXL1 in haematopoietic stem cells (HSCs) leads to Akt de-ubiquitination, activated Akt/mTOR signaling, and aberrant HSC proliferation.Takeshi FujinoSusumu GoyamaYuki SugiuraDaichi InoueShuhei AsadaSatoshi YamasakiAkiko MatsumotoKiyoshi YamaguchiYumiko IsobeAkiho TsuchiyaShiori ShikataNaru SatoHironobu MorinagaTomofusa FukuyamaYosuke TanakaTsuyoshi FukushimaReina TakedaKeita YamamotoHiroaki HondaEmi K. NishimuraYoichi FurukawaTatsuhiro ShibataOmar Abdel-WahabMakoto SuematsuToshio KitamuraNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-20 (2021) |
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Science Q Takeshi Fujino Susumu Goyama Yuki Sugiura Daichi Inoue Shuhei Asada Satoshi Yamasaki Akiko Matsumoto Kiyoshi Yamaguchi Yumiko Isobe Akiho Tsuchiya Shiori Shikata Naru Sato Hironobu Morinaga Tomofusa Fukuyama Yosuke Tanaka Tsuyoshi Fukushima Reina Takeda Keita Yamamoto Hiroaki Honda Emi K. Nishimura Yoichi Furukawa Tatsuhiro Shibata Omar Abdel-Wahab Makoto Suematsu Toshio Kitamura Mutant ASXL1 induces age-related expansion of phenotypic hematopoietic stem cells through activation of Akt/mTOR pathway |
| description |
ASXL1 mutations are frequently found in age-related clonal haemaotopoiesis (CH), but how they drive CH is unclear. Here the authors show that expression of C-terminal truncated ASXL1 in haematopoietic stem cells (HSCs) leads to Akt de-ubiquitination, activated Akt/mTOR signaling, and aberrant HSC proliferation. |
| format |
article |
| author |
Takeshi Fujino Susumu Goyama Yuki Sugiura Daichi Inoue Shuhei Asada Satoshi Yamasaki Akiko Matsumoto Kiyoshi Yamaguchi Yumiko Isobe Akiho Tsuchiya Shiori Shikata Naru Sato Hironobu Morinaga Tomofusa Fukuyama Yosuke Tanaka Tsuyoshi Fukushima Reina Takeda Keita Yamamoto Hiroaki Honda Emi K. Nishimura Yoichi Furukawa Tatsuhiro Shibata Omar Abdel-Wahab Makoto Suematsu Toshio Kitamura |
| author_facet |
Takeshi Fujino Susumu Goyama Yuki Sugiura Daichi Inoue Shuhei Asada Satoshi Yamasaki Akiko Matsumoto Kiyoshi Yamaguchi Yumiko Isobe Akiho Tsuchiya Shiori Shikata Naru Sato Hironobu Morinaga Tomofusa Fukuyama Yosuke Tanaka Tsuyoshi Fukushima Reina Takeda Keita Yamamoto Hiroaki Honda Emi K. Nishimura Yoichi Furukawa Tatsuhiro Shibata Omar Abdel-Wahab Makoto Suematsu Toshio Kitamura |
| author_sort |
Takeshi Fujino |
| title |
Mutant ASXL1 induces age-related expansion of phenotypic hematopoietic stem cells through activation of Akt/mTOR pathway |
| title_short |
Mutant ASXL1 induces age-related expansion of phenotypic hematopoietic stem cells through activation of Akt/mTOR pathway |
| title_full |
Mutant ASXL1 induces age-related expansion of phenotypic hematopoietic stem cells through activation of Akt/mTOR pathway |
| title_fullStr |
Mutant ASXL1 induces age-related expansion of phenotypic hematopoietic stem cells through activation of Akt/mTOR pathway |
| title_full_unstemmed |
Mutant ASXL1 induces age-related expansion of phenotypic hematopoietic stem cells through activation of Akt/mTOR pathway |
| title_sort |
mutant asxl1 induces age-related expansion of phenotypic hematopoietic stem cells through activation of akt/mtor pathway |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/5a4339b6caee4c1d9bbb984e54dddbf0 |
| work_keys_str_mv |
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1718393095351959552 |