Association between vitamin D and pressure ulcers in older ambulatory adults: results of a matched case–control study

Association between vitamin D and pressure ulcers in older ambulatory adults: results of a matched case–control study

Usha R Kalava1, Stephen S Cha2, Paul Y Takahashi1,31Department of Internal Medicine, Division of Primary Care Internal Medicine, 2Department of Biostatistics, 3Kogod Center of Aging, Mayo Clinic, Rochester, MN, USABackground: Pressure ulcers are common among older adults, but knowledge about nutriti...

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Autores principales: Kalava UR, Cha SS, Takahashi PY
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2011
Materias:
Pressure ulcer
Vitamin D
Case control study
aging
geriatrics
Geriatrics
RC952-954.6
Acceso en línea:https://doaj.org/article/5a49457cd56f4132a4f36dd8167383a3
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spelling oai:doaj.org-article:5a49457cd56f4132a4f36dd8167383a32021-12-02T07:45:04ZAssociation between vitamin D and pressure ulcers in older ambulatory adults: results of a matched case–control study1178-1998https://doaj.org/article/5a49457cd56f4132a4f36dd8167383a32011-08-01T00:00:00Zhttps://www.dovepress.com/association-between-vitamin-d-and-pressure-ulcers-in-older-ambulatory--peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Usha R Kalava1, Stephen S Cha2, Paul Y Takahashi1,31Department of Internal Medicine, Division of Primary Care Internal Medicine, 2Department of Biostatistics, 3Kogod Center of Aging, Mayo Clinic, Rochester, MN, USABackground: Pressure ulcers are common among older adults, but knowledge about nutritional risk factors is still developing. Vitamin D deficiency is common in the elderly population and is required for normal skin proliferation. The role of vitamin D in pressure ulceration and wound healing is not known. The purpose of this case–control study was to determine the association between vitamin D levels and pressure ulceration in an older community-dwelling cohort.Methods: All cases and controls were community-dwelling elderly older than 60 years in a primary care panel in Olmsted County, MN. Pressure ulcer cases were defined clinically. The controls were age-matched and gender-matched to controls without pressure ulceration. The main exposure variable was 25-hydroxyvitamin D levels in both groups. The other exposure variable was the Charlson Comorbidity Index used to measure medical comorbidity. The analysis included univariate and conditional logistic regression for 25-hydroxyvitamin D levels.Results: The average (standard deviation) age of the study participants with a pressure ulcer was 80.46 years (±8.67), and the average vitamin D level was 30.92 ng/mL (±12.46). In univariate analysis, Vitamin D deficiency (levels < 25 ng/mL) was associated with pressure ulcers (odds ratio: 1.871, P = 0.0154). Comorbidities of the subjects calculated using the Charlson Comorbidity Index were also associated with pressure ulcers (odds ratio: 1.136, P < 0.001). In the final conditional logistical regression model, the association of Vitamin D and pressure ulcers became nonsignificant after adjustment for comorbid illness.Conclusion: Medical comorbidities increased the risk of pressure ulceration. Vitamin D deficiency was not an independent risk factor for pressure ulceration, and may be a marker of comorbid illness.Keywords: pressure ulcer, vitamin D, case–control study, aging, geriatricsKalava URCha SSTakahashi PYDove Medical PressarticlePressure ulcerVitamin DCase control studyaginggeriatricsGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 6, Pp 213-219 (2011)
institution DOAJ
collection DOAJ
language EN
topic Pressure ulcer
Vitamin D
Case control study
aging
geriatrics
Geriatrics
RC952-954.6
spellingShingle Pressure ulcer
Vitamin D
Case control study
aging
geriatrics
Geriatrics
RC952-954.6
Kalava UR
Cha SS
Takahashi PY
Association between vitamin D and pressure ulcers in older ambulatory adults: results of a matched case–control study
description Usha R Kalava1, Stephen S Cha2, Paul Y Takahashi1,31Department of Internal Medicine, Division of Primary Care Internal Medicine, 2Department of Biostatistics, 3Kogod Center of Aging, Mayo Clinic, Rochester, MN, USABackground: Pressure ulcers are common among older adults, but knowledge about nutritional risk factors is still developing. Vitamin D deficiency is common in the elderly population and is required for normal skin proliferation. The role of vitamin D in pressure ulceration and wound healing is not known. The purpose of this case–control study was to determine the association between vitamin D levels and pressure ulceration in an older community-dwelling cohort.Methods: All cases and controls were community-dwelling elderly older than 60 years in a primary care panel in Olmsted County, MN. Pressure ulcer cases were defined clinically. The controls were age-matched and gender-matched to controls without pressure ulceration. The main exposure variable was 25-hydroxyvitamin D levels in both groups. The other exposure variable was the Charlson Comorbidity Index used to measure medical comorbidity. The analysis included univariate and conditional logistic regression for 25-hydroxyvitamin D levels.Results: The average (standard deviation) age of the study participants with a pressure ulcer was 80.46 years (±8.67), and the average vitamin D level was 30.92 ng/mL (±12.46). In univariate analysis, Vitamin D deficiency (levels < 25 ng/mL) was associated with pressure ulcers (odds ratio: 1.871, P = 0.0154). Comorbidities of the subjects calculated using the Charlson Comorbidity Index were also associated with pressure ulcers (odds ratio: 1.136, P < 0.001). In the final conditional logistical regression model, the association of Vitamin D and pressure ulcers became nonsignificant after adjustment for comorbid illness.Conclusion: Medical comorbidities increased the risk of pressure ulceration. Vitamin D deficiency was not an independent risk factor for pressure ulceration, and may be a marker of comorbid illness.Keywords: pressure ulcer, vitamin D, case–control study, aging, geriatrics
format article
author Kalava UR
Cha SS
Takahashi PY
author_facet Kalava UR
Cha SS
Takahashi PY
author_sort Kalava UR
title Association between vitamin D and pressure ulcers in older ambulatory adults: results of a matched case–control study
title_short Association between vitamin D and pressure ulcers in older ambulatory adults: results of a matched case–control study
title_full Association between vitamin D and pressure ulcers in older ambulatory adults: results of a matched case–control study
title_fullStr Association between vitamin D and pressure ulcers in older ambulatory adults: results of a matched case–control study
title_full_unstemmed Association between vitamin D and pressure ulcers in older ambulatory adults: results of a matched case–control study
title_sort association between vitamin d and pressure ulcers in older ambulatory adults: results of a matched case–control study
publisher Dove Medical Press
publishDate 2011
url https://doaj.org/article/5a49457cd56f4132a4f36dd8167383a3
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AT takahashipy associationbetweenvitamindandpressureulcersinolderambulatoryadultsresultsofamatchedcasendashcontrolstudy
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