Effect of symptom-based alpha-blocker treatment on lower urinary tract symptoms in women: systematic review and meta-analysis

Aims: The aim of this study was to evaluate the effects of alpha blockers in women with lower urinary tract symptoms. Methods: We conducted systematic review and meta-analysis on published a priori protocols. We searched multiple data sources for published and unpublished randomized controlled trial...

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Autores principales:	Tae Wook Kang, Su Jin Kim, Ki Don Chang, Myung Ha Kim, Hyun Chul Chung
Formato:	article
Lenguaje:	EN
Publicado:	SAGE Publishing 2021
Materias:	Diseases of the genitourinary system. Urology RC870-923
Acceso en línea:	https://doaj.org/article/5a4ba71130364e6e927a604cd548f784
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spelling	oai:doaj.org-article:5a4ba71130364e6e927a604cd548f7842021-11-12T10:03:36ZEffect of symptom-based alpha-blocker treatment on lower urinary tract symptoms in women: systematic review and meta-analysis1756-288010.1177/17562872211053679https://doaj.org/article/5a4ba71130364e6e927a604cd548f7842021-10-01T00:00:00Zhttps://doi.org/10.1177/17562872211053679https://doaj.org/toc/1756-2880Aims: The aim of this study was to evaluate the effects of alpha blockers in women with lower urinary tract symptoms. Methods: We conducted systematic review and meta-analysis on published a priori protocols. We searched multiple data sources for published and unpublished randomized controlled trials in any language. Primary outcomes included urologic symptom scores, quality of life, and overall adverse events. We performed meta-analysis using RevMan 5.3 and rated the certainty of evidence using Grading of Recommendations, Assessment, Development, and Evaluation. Results: Alpha blockers likely reduced urological symptom score (mean difference: −1.50, 95% confidence interval: −2.91 to −0.09; moderate certainty of evidence). Alpha blockers may improve quality of life (standardized mean difference: −0.35, 95% confidence interval: −0.85 to 0.15; low certainty of evidence) and have little to no difference in overall adverse events (risk ratio: 1.09, 95% confidence interval: 0.55 to 2.15; low certainty of evidence). Based on five studies comparing combination therapy with alpha blockers and anticholinergics to anticholinergic monotherapy, combination therapy likely results in little to no difference in urological symptom score (mean difference: −0.35, 95% confidence interval: −1.98 to 1.27; moderate certainty of evidence) and quality of life (mean difference: −0.11, 95% confidence interval: −0.48 to 0.27; moderate certainty of evidence). We are very uncertain about the effect of combination therapy on overall adverse events (risk ratio: 1.07, 95% confidence interval: 0.40 to 2.84; very low certainty of evidence). Conclusion: Alpha blocker monotherapy for the women with lower urinary tract symptoms regardless of the underlying cause likely has satisfactory efficacy compared with placebo. However, combination therapy with anticholinergics likely has no additional effect on urologic symptom score and quality of life compared with anticholinergic monotherapy.Tae Wook KangSu Jin KimKi Don ChangMyung Ha KimHyun Chul ChungSAGE PublishingarticleDiseases of the genitourinary system. UrologyRC870-923ENTherapeutic Advances in Urology, Vol 13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the genitourinary system. Urology RC870-923
spellingShingle	Diseases of the genitourinary system. Urology RC870-923 Tae Wook Kang Su Jin Kim Ki Don Chang Myung Ha Kim Hyun Chul Chung Effect of symptom-based alpha-blocker treatment on lower urinary tract symptoms in women: systematic review and meta-analysis
description	Aims: The aim of this study was to evaluate the effects of alpha blockers in women with lower urinary tract symptoms. Methods: We conducted systematic review and meta-analysis on published a priori protocols. We searched multiple data sources for published and unpublished randomized controlled trials in any language. Primary outcomes included urologic symptom scores, quality of life, and overall adverse events. We performed meta-analysis using RevMan 5.3 and rated the certainty of evidence using Grading of Recommendations, Assessment, Development, and Evaluation. Results: Alpha blockers likely reduced urological symptom score (mean difference: −1.50, 95% confidence interval: −2.91 to −0.09; moderate certainty of evidence). Alpha blockers may improve quality of life (standardized mean difference: −0.35, 95% confidence interval: −0.85 to 0.15; low certainty of evidence) and have little to no difference in overall adverse events (risk ratio: 1.09, 95% confidence interval: 0.55 to 2.15; low certainty of evidence). Based on five studies comparing combination therapy with alpha blockers and anticholinergics to anticholinergic monotherapy, combination therapy likely results in little to no difference in urological symptom score (mean difference: −0.35, 95% confidence interval: −1.98 to 1.27; moderate certainty of evidence) and quality of life (mean difference: −0.11, 95% confidence interval: −0.48 to 0.27; moderate certainty of evidence). We are very uncertain about the effect of combination therapy on overall adverse events (risk ratio: 1.07, 95% confidence interval: 0.40 to 2.84; very low certainty of evidence). Conclusion: Alpha blocker monotherapy for the women with lower urinary tract symptoms regardless of the underlying cause likely has satisfactory efficacy compared with placebo. However, combination therapy with anticholinergics likely has no additional effect on urologic symptom score and quality of life compared with anticholinergic monotherapy.
format	article
author	Tae Wook Kang Su Jin Kim Ki Don Chang Myung Ha Kim Hyun Chul Chung
author_facet	Tae Wook Kang Su Jin Kim Ki Don Chang Myung Ha Kim Hyun Chul Chung
author_sort	Tae Wook Kang
title	Effect of symptom-based alpha-blocker treatment on lower urinary tract symptoms in women: systematic review and meta-analysis
title_short	Effect of symptom-based alpha-blocker treatment on lower urinary tract symptoms in women: systematic review and meta-analysis
title_full	Effect of symptom-based alpha-blocker treatment on lower urinary tract symptoms in women: systematic review and meta-analysis
title_fullStr	Effect of symptom-based alpha-blocker treatment on lower urinary tract symptoms in women: systematic review and meta-analysis
title_full_unstemmed	Effect of symptom-based alpha-blocker treatment on lower urinary tract symptoms in women: systematic review and meta-analysis
title_sort	effect of symptom-based alpha-blocker treatment on lower urinary tract symptoms in women: systematic review and meta-analysis
publisher	SAGE Publishing
publishDate	2021
url	https://doaj.org/article/5a4ba71130364e6e927a604cd548f784
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Effect of symptom-based alpha-blocker treatment on lower urinary tract symptoms in women: systematic review and meta-analysis

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